Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

Wang, Congli; Huang, Lijia; Shi, Sun; Saif, Bassam; Zhou, Yehong; Dong, Chuan; Shuang, Shaomin

doi:10.1016/j.apsusc.2015.09.189

Cited by 31 publications

(13 citation statements)

References 44 publications

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“…Besides their specific magnetic properties [54], magnetite (Fe 3 O 4 ) nanoparticles are friendly to biological tissues and fluids, the biocompatibility [34,35,36,55] making them promising candidates for numerous biomedical applications, like: (1) drug delivery systems [56,57,58,59]; (2) hyperthermia cancer treatment [60,61,62,63,64]; (3) contrasting agent in magnetic resonance imaging [11,27,65,66]; (4) inhibition of biofilm development [67,68,69,70,71,72,73]. …”

Section: Discussionmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

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Nanotechnology has been successfully used for the fabrication of targeted anti-cancer drug carriers. This study aimed to obtain Fe3O4 nanoparticles functionalized with Gemcitabine to improve the cytotoxic effects of the chemotherapeutic substance on cancer cells. The (un) functionalized magnetite nanoparticles were synthesized using a modified co-precipitation method. The nanoconjugate characterization was performed by XRD, SEM, SAED and HRTEM; the functionalizing of magnetite with anti-tumor substances has been highlighted through TGA. The interaction with biologic media has been studied by means of stability and agglomeration tendency (using DLS and Zeta Potential); also, the release kinetics of the drug in culture media was evaluated. Cytotoxicity of free-Gemcitabine and the obtained nanoconjugate were evaluated on human BT 474 breast ductal carcinoma, HepG2 hepatocellular carcinoma and MG 63 osteosarcoma cells by MTS. In parallel, cellular morphology of these cells were examined through fluorescence microscopy and SEM. The localization of the nanoparticles related to the cells was studied using SEM, EDX and TEM. Hemolysis assay showed no damage of erythrocytes. Additionally, an in vivo biodistribution study was made for tracking where Fe3O4@Gemcitabine traveled in the body of mice. Our results showed that the transport of the drug improves the cytotoxic effects in comparison with the one produced by free Gemcitabine for the BT474 and HepG2 cells. The in vivo biodistribution test proved nanoparticle accumulation in the vital organs, with the exception of spleen, where black-brown deposits have been found. These results indicate that our Gemcitabine-functionalized nanoparticles are a promising targeted system for applications in cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

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“…Many types of novel MTX delivery systems have been reported, such as nanoparticles [7][8][9], microspheres [10], liposomes [11], polymeric micelles [12] and miscellaneous multiparticulate systems [13]. Among these, nanoparticles, especially the magnetic iron oxide (Fe3O4) nanoparticles seem to be a promising tool for site specific delivery [14,15], based on the fact that they will release the anticancer drug on tumor cells owing to the enhanced permeability and retention (EPR) effect [16,17] and passive drug targeting. Furthermore, recently layered double hydroxide (LDH) nanoparticles have been proven effective for site-specific delivery of anticancer drugs to tumor and reduce its side effects, due to their inherent properties such as high biocompatibility [18], low cytotoxicity [19], the ability to accommodate various biologically important molecules including genes and drugs [20][21][22], and the partial dissolution of LDH layers in endosome that not only stops the passive control release of drugs, but also buffers the excess protons, which helps the drugs to escape from endosome, improves the viability of drugs in cytoplasm, and enhances the delivery efficacy [23].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in vitro evaluation of pH-sensitive magnetic nanocomposites as methotrexate delivery system for targeted cancer therapy

Deng

Jiang

et al. 2017

Materials Science and Engineering: C

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This study focuses on the synthesis and in vitro evaluation of magnetic nanocomposites (FeO@LDH) as methotrexate (MTX) delivery system for targeted anticancer therapy. In which, the FeO nanoparticles acted as magnetically responsive carriers; the coating layer of layered double hydroxide (LDH) was used as a storehouse for MTX. The prepared FeO@LDH nanocomposites exhibited a suitable size, good stability and magnetic responsibility (M 36.66emu/g); MTX successfully intercalated into the LDH of FeO@LDH at an entrapment rate (%) of 91.78% (the drug loading was 18.36%) by host-guest exchange process. Moreover, the release studies in vitro showed that the drug delivery system (FeO@LDH-MTX) had excellent pH-sensitivity, 84.94% of MTX was released within 48h at pH3.5 via the co-effect of dissolution of LDH layer and ion-exchange. WST-1 assays in cancer cells (MCF-7 and HepG2) and normal cells (HUVEC) demonstrated that FeO@LDH-MTX exhibited high anticancer activity while low toxicity to normal cells, and also the FeO@LDH composites were practically non-toxic. Thus, our results revealed that FeO@LDH-MTX would be a competitive candidate for targeted delivery and sustained and controlled release of MTX.

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“…Magnetic nanoparticles (NPs), especially magnetite (Fe 3 O 4 ), can be widely used in science, technology, and healthcare in applications such as cell separation (1), microwave absorption (2), magnetic resonance imaging (MRI) techniques (3), recording materials (3), ferrofluids (4), biological sensing (5), bioactive molecule separation (3), catalysis (6)(7)(8), and magnetic targeted therapy (9). For future highly sensitive magnetic nanostructures and biological and pharmacological applications, Fe 3 O 4 NPs with controlled size, shape, and a narrow size distribution are needed.…”

Section: Introductionmentioning

confidence: 99%

Modified chemical coprecipitation of magnetic magnetite nanoparticles using linear–dendritic copolymers

Zarnegar

Safari

2017

Green Chemistry Letters and Reviews

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In this investigation, magnetite nanoparticles (Fe 3 O 4 NPs) with a diameter of 5-10 nm were synthesized by coprecipitation from an alkaline solution of ferrous/ferric mixed salt-solution in the presence of copolymers. In this process, linear-dendritic copolymers containing a linear poly (ethylene glycol) core and dendritic poly (citric acid) arms were used as the stabilizer. The Fe 3 O 4 NPs were characterized by transmission electron microscopy, energy-dispersive spectra, X-ray powder diffraction, field emission scanning electron microscopy, Fourier transform infrared spectrometer, and vibrating sample magnetometer. Compared to classical coprecipitation, the results showed that uniform, ultrafine, nearly spherical, and high purity nano-magnetite particles with better magnetic properties could be prepared by this method. ARTICLE HISTORY

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Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

Cited by 31 publications

References 44 publications

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Synthesis and in vitro evaluation of pH-sensitive magnetic nanocomposites as methotrexate delivery system for targeted cancer therapy

Modified chemical coprecipitation of magnetic magnetite nanoparticles using linear–dendritic copolymers

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