Dextran-encapsulated barium sulfate nanoparticles prepared for aqueous dispersion as an X-ray contrast agent

Meagher, Matthew J.; Leone, Bridget; Turnbull, Travis Lee; Ross, Ryan D.; Zhang, Zhenyuan; Roeder, Ryan K.

doi:10.1007/s11051-013-2146-8

Cited by 19 publications

(13 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prussian blue's high affinity to heavy metals may be exploited beyond heavy metal poisoning treatment, its current clinical use. This attribute could allowing tagging of PBNCs with compounds such as barium sulfate to enable X-ray imaging contrast [52]. Besides magnetic manipulation and magnetomotive imaging techniques, PBNC's magnetic properties could enhance magnetic hyperthermia using alternating magnetic fields, potentially improving therapeutic penetration depth [29,53], with the possibility to be combined with photothermal therapy to augment heating capability [54].…”

Section: Discussionmentioning

confidence: 99%

Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Dumani

Cook

Kubelick

et al. 2020

Nanomedicine: Nanotechnology, Biology and Medicine

View full text Add to dashboard Cite

Nanoparticles play an important role in biomedicine. We have developed a method for sizecontrolled synthesis of photomagnetic Prussian blue nanocubes (PBNCs) using superparamagnetic iron oxide nanoparticles (SPIONs) as precursors. The developed PBNCs have magnetic and optical properties desired in many biomedical diagnostic and therapeutic applications. Specifically, the size-tunable photomagnetic PBNCs exhibit high magnetic saturation, strong optical absorption with a peak at approximately 700 nm, and superior photostability. Our studies demonstrate that PBNCs can be used as MRI and photoacoustic imaging contrast agents in vivo. We also showed the utility of PBNCs for labeling and magnetic manipulation of cells. Dual magnetic and optical properties, together with excellent biocompatibility, render PBNCs an attractive contrast agent for both diagnostic and therapeutic applications. The use SPIONs as precursors for PBNCs provides flexibility and allows researchers to design theranostic agents according to required particle size, optical, and magnetic properties.

show abstract

Section: Discussionmentioning

confidence: 99%

Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Dumani

Cook

Kubelick

et al. 2020

Nanomedicine: Nanotechnology, Biology and Medicine

View full text Add to dashboard Cite

show abstract

“…The composites of PLA with inorganic fillers have been proved very useful to enhance the impact toughness and thermal properties without significant deteriorated strength and stiffness, of which barium sulfate (BaSO 4 ) must be the most promising candidate . BaSO 4 is a well‐known bioinert filler and usually considered as the gold standard in clinical applications for the x‐ray photography and gamma‐ray absorber, because it is nonharmful to humans and possessed of characteristic radiopacity and biocompatibility . So, it is very suitable for such inorganic filler to design and fabricate the PLA composites with high biosafety.…”

Section: Introductionmentioning

confidence: 97%

Investigation on the environmental‐friendly poly(lactic acid) composites based on precipitated barium sulfate: Mechanical, thermal properties, and kinetic study of thermal degradation

Yang

Nie

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

A novel environmental‐friendly poly(lactic acid) (PLA) composites based on precipitated barium sulfate (BaSO4) were prepared via melt‐compounding. The mechanical properties and thermal stability of PLA/BaSO4 composites were investigated. To dig the decomposition mechanism, kinetic analysis of thermal degradation was emphasized systematically based on nonisothermal thermograms. Results showed that the mechanical responses were improved remarkably both under the quasi‐static condition and subjected to high‐speed shock due to the well‐bonded interfaces between PLA and BaSO4. Meanwhile, the added BaSO4 suppressed the mass conversion rate of PLA phase and improved the thermal stability at high temperature. Due to the inhibition of BaSO4, the calculated activation energy was enhanced obviously according to model‐free isoconversional approaches. Finally, the apparent kinetic mechanism and reaction order for the over‐all thermal degradation were determined by the combination of model‐fitting approaches and Carrasco method. From this study, we hope to provide a facile method to prepare environmental‐friendly PLA composites with excellent mechanical properties and thermal stability. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47995.

show abstract

“…There has been interest in investigating barium as one component of a multiple-agent contrast-enhanced DECT exam protocol to improve diagnostic capability[132, 133]. Barium sulfate nanoparticles have also been prepared for animal research[134]. Another paper reported the synthesis of barium carbonate nanoparticles coated with D-glucuronic acid which were imaged in mice[135].…”

Section: Choice Of Elements For Spectral Ct Contrast Materialsmentioning

confidence: 99%

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies

Yeh

Fitzgerald

Edic

et al. 2017

Advanced Drug Delivery Reviews

157

144

View full text Add to dashboard Cite

The introduction of spectral CT imaging in the form of fast clinical dual-energy CT enabled contrast material to be differentiated from other radiodense materials, improved lesion detection in contrast-enhanced scans, and changed the way that existing iodine and barium contrast materials are used in clinical practice. More profoundly, spectral CT can differentiate between individual contrast materials that have different reporter elements such that high-resolution CT imaging of multiple contrast agents can be obtained in a single pass of the CT scanner. These spectral CT capabilities would be even more impactful with the development of contrast materials designed to complement the existing clinical iodine- and barium-based agents. New biocompatible high-atomic number contrast materials with different biodistribution and X-ray attenuation properties than existing agents will expand the diagnostic power of spectral CT imaging without penalties in radiation dose or scan time.

show abstract

Dextran-encapsulated barium sulfate nanoparticles prepared for aqueous dispersion as an X-ray contrast agent

Cited by 19 publications

References 42 publications

Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Investigation on the environmental‐friendly poly(lactic acid) composites based on precipitated barium sulfate: Mechanical, thermal properties, and kinetic study of thermal degradation

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies

Contact Info

Product

Resources

About