Dexmedetomidine Decreases Thiopental Dose Requirement and Alters Distribution Pharmacokinetics

Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs

“…Likewise, dexmedetomidine has been suggested to alter its own pharmacokinetics in dogs (Salonen et al, 1995;Kuusela et al, 2000). It also reduces the distribution of thiopental in humans (Bührer et al, 1994).…”

Influência da dexmedetomidina na concentração expirada do sevoflurano: avaliação pelo índice bispectral, taxa de supressão e análise espectral da potência do eletroencefalograma

“…There are also evidences that dexmedetomidine changes intravenous agents distribution, possibly due to a decrease in cardiac output 40 . Studies have also shown that dexmedetomidine significantly decreases midazolam or propofol consumption 41,42 as compared to placebo in patients under mechanical ventilation and sedation.…”

Oral clonidine reduces thiamylal requirement for induction of anesthesia in adult patients

“…Furthermore, there is an investigation showing a profound reduction in anesthetic requirements with dexmedetomidine, a more specific and selective a-2 adrenergic agonist, thus raising the possibility that a-2 adrenergic agonists may be considered as anesthetic agents when administered alone [20]. Alternatively, this finding could be explained by pharmacokinetic alterations of barbiturate following administration of an a-2 agonist, since dexmedetomidine has been shown to decrease thiopental distribution volume and clearance [21].…”