Dexamethasone for the Treatment of Sore Throat in Children With Suspected Infectious Mononucleosis

Roy, Michel; Bailey, Benoît; Amre, Devendra; Girodias, Jean-Bernard; Bussières, J.-F.; Gaudreault, Pierre

doi:10.1001/archpedi.158.3.250

Cited by 45 publications

(11 citation statements)

References 20 publications

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“…It has been reported to have a prophylactic effect on postoperative nausea and vomiting [2,4], and the efficacy of dexamethasone in the treatment of sore throat has been reported [1,5,6]. Moreover, recent studies have demonstrated that preoperative intravenous administration of dexamethasone significantly reduces the incidence of postoperative sore throat (POST) [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prophylactic effect of dexamethasone in reducing postoperative sore throat

Park

Kim

Lee

et al. 2010

Korean J Anesthesiol

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BackgroundThis study was performed to compare the effectiveness of prophylactic dexamethasone and postintubation dexamethasone in reducing the incidence and severity of postoperative sore throat (POST).MethodsThis was a prospective, randomized, double-blind clinical trial. The study population consisted of 70 patients between 20 and 60 years old who were classified as American Society of Anesthesiologists I-II and were scheduled for elective laparoscopic cholecystectomy. The patients were divided randomly into two groups. Patients in the prophylactic and postintubation groups received intravenous injection of 10 mg of dexamethasone 30 min before or after tracheal intubation, respectively. The patients were interviewed 1, 6, and 24 h after the operation. The incidence and severity of POST were recorded.ResultsThe severity scores of POST at 1 and 6 h after the operation were significantly lower in the prophylactic group than in the postintubation group. There were no significant differences in the incidence of POST during the 24 h after the operation between the two groups (22/32 in the prophylactic group vs. 27/34 in the postintubation group, P = 0.403).ConclusionsIntravenous injection of 10 mg of dexamethasone was more effective in reducing the severity of POST when administered before tracheal intubation compared with after tracheal intubation.

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Section: Introductionmentioning

confidence: 99%

Prophylactic effect of dexamethasone in reducing postoperative sore throat

Park

Kim

Lee

et al. 2010

Korean J Anesthesiol

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“…While corticosteroids have been used to treat airway compromise due to tonsillar inflammation, they may also be of some benefit for the pain associated with IM. However, Roy et al have shown that, in a pediatric population, a single dose of dexamethasone for treatment of sore throat associated with mononucleosis may not be sufficient for resolution of symptoms (6). Furthermore, the use of glucocorticoids for symptomatic relief may predispose patients to bacterial superinfections (3).…”

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confidence: 99%

Unilateral Empyema as a Complication of Infectious Mononucleosis: a Pathogenic Variant of Lemierre’s Syndrome

Matten

Grecu

2006

J Clin Microbiol

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“…[23] Dexamethasone is a potent corticosteroid with analgesic and anti-inflammatory effects,[242526] that has a prophylactic effect on post-operative nausea and vomiting,[2527] and prescribed for the treatment of a sore throat resulting from tracheal mechanical irritation due to its modulating effects of tissue edema and pain. [24282930] Canbay et al .,[18] in one study showed that ketamine gargle significantly reduced the incidence and severity of POST but in this study, ketmaine couldn’t reduce the incidence and severity of sore throat at all times up to 24 h after surgery. In the other hand, Park et al .,[11] in one study concluded that the prophylactic use of 0.2 mg/kg of dexamethasone significantly decreases the incidence and severity of sore throat and hoarseness 1 h and 24 h after tracheal extubation of a double-lumen tube (DLT).…”

Section: Introductionmentioning

confidence: 54%

Intravenous dexamethasone versus ketamine gargle versus intravenous dexamethasone combined with ketamine gargle for evaluation of post-operative sore throat and hoarseness: A randomized, placebo-controlled, double blind clinical trial

et al. 2014

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Background:Sore throat and hoarseness are the most frequent subjective complaints after tracheal intubation for general anesthesia. We conducted a prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intravenous (IV) dexamethasone plus ketamine gargle for reducing the incidence and severity of post-operative sore throat (POST) and hoarseness.Materials and Methods:140 patients (aged 16-65 year) scheduled for elective surgery were enrolled. Patients were randomly allocated into four groups of 35 subjects each: Group K, gargled 40 mg ketamine in 30 ml saline; Group D, were infused 0.2 mg/kg IV dexamethasone; Group KD, gargled 40 mg ketamine in 30 ml saline plus 0.2 mg/kg IV dexamethasone; Group P (placebo) that received saline (gargle and IV). POST was graded at 0, 2, 4, 8, 16 and 24 h after operation on a four-point scale (0-3).Results:The incidence and severity of POST were significantly lower in Group KD, compared with the other groups at all times after tracheal extubation for up to 24 h (P < 0.05). Also the incidence and severity of hoarseness were significantly lower in each Groups of KD and K and D compared with group placebo (P < 0.05).Conclusion:The prophylactic use of 0.2 mg/kg of IV dexamethasone plus ketamine gargle significantly reduced the incidence and severity of POST compared with using each of these drugs alone or using placebo.

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Dexamethasone for the Treatment of Sore Throat in Children With Suspected Infectious Mononucleosis

Abstract: The short-lived relief of pain in acute exudative pharyngitis in children with suspected infectious mononucleosis may suggest that a single oral dose of dexamethasone may not be sufficient and that additional doses may be necessary for ensuring lasting relief.

Cited by 45 publications

References 20 publications

Prophylactic effect of dexamethasone in reducing postoperative sore throat

Prophylactic effect of dexamethasone in reducing postoperative sore throat

Unilateral Empyema as a Complication of Infectious Mononucleosis: a Pathogenic Variant of Lemierre’s Syndrome

Intravenous dexamethasone versus ketamine gargle versus intravenous dexamethasone combined with ketamine gargle for evaluation of post-operative sore throat and hoarseness: A randomized, placebo-controlled, double blind clinical trial

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