Prophylactic effect of dexamethasone in reducing postoperative sore throat

Abstract

BackgroundThis study was performed to compare the effectiveness of prophylactic dexamethasone and postintubation dexamethasone in reducing the incidence and severity of postoperative sore throat (POST).MethodsThis was a prospective, randomized, double-blind clinical trial. The study population consisted of 70 patients between 20 and 60 years old who were classified as American Society of Anesthesiologists I-II and were scheduled for elective laparoscopic cholecystectomy. The patients were divided randomly into two groups. Patients in the prophylactic and postintubation groups received intravenous injection of 10 mg of dexamethasone 30 min before or after tracheal intubation, respectively. The patients were interviewed 1, 6, and 24 h after the operation. The incidence and severity of POST were recorded.ResultsThe severity scores of POST at 1 and 6 h after the operation were significantly lower in the prophylactic group than in the postintubation group. There were no significant differences in the incidence of POST during the 24 h after the operation between the two groups (22/32 in the prophylactic group vs. 27/34 in the postintubation group, P = 0.403).ConclusionsIntravenous injection of 10 mg of dexamethasone was more effective in reducing the severity of POST when administered before tracheal intubation compared with after tracheal intubation.

Application of triamcinolone acetonide paste to the endotracheal tube reduces postoperative sore throat: a randomized controlled trial

“…Some studies have demonstrated that preoperative intravenous administration of dexamethasone reduces the incidence of POST significantly. [22][23][24] We used a similar dose of dexamethasone as used in these studies, which may have conflicted with the proposed effect of the lubricants. In our study, however, both groups received the same dose of dexamethasone following intubation.…”

Preventive effect of ketamine gargling for postoperative sore throat after endotracheal intubation

“…Generally, POST is resolved spontaneously without specific treatment; however, many patients complain of POST after general anesthesia with endotracheal intubation. Several pharmacological and non-pharmacological trials have been performed to decrease POST [1,[10][11][12][13][14]. Kalil et al [15] reported that preoperative ketamine and aspirin gargle was the most promising pharmacological method for providers practicing in the United States.…”

Gambaran Kejadian Nyeri Tenggorok dan Serak pada Pasien yang Menjalani Anestesi Umum Endotrakeal di RSUD Arifin Achmad Pekanbaru

“…Hal ini berakibat pada timbulnya ketidakpuasan pasien dan terkadang berujung pada claim terhadap rumah sakit. 5,13,[20][21][22] Tingginya insidensi keluhan nyeri tenggorok dan serak pada pasien yang menjalani anestesi umum endotrakeal berdasarkan literatur dan cukup besarnya dampak yang ditimbulkan membangkitkan minat peneliti untuk meneliti mengenai topik ini. Mengingat belum adanya penelitian mengenai hal ini di RSUD Arifin Achmad Pekanbaru, maka peneliti tertarik untuk mengetahui bagaimana gambaran kejadian nyeri tenggorok dan serak pada pasien yang menjalani anestesi umum endotrakeal di RSUD Arifin Achmad Pekanbaru.…”