Dexamethasone coordinately regulates angiopoietin-1 and VEGF: A mechanism of glucocorticoid-induced stabilization of blood–brain barrier

Kim, Hyongbum; Lee, Jung Min; Park, Jae Sun; Jo, Sangmee Ahn; Kim, Yong Ou; Kim, Chan Wha; Jo, Inho

doi:10.1016/j.bbrc.2008.05.025

Cited by 119 publications

(89 citation statements)

References 33 publications

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“…However, effects of GR appeared without transcriptional modulation [100]. In this experimental study, transcriptional regulation of Ang-1 and VEGF by dexamethasone occurred via Ang-1 up-regulation and VEGF down-regulation, because dexamethasone did not affect Ang-1 and VEGF mRNA stabilities [97]. In has been shown in several studies that glucocorticoid induced down-regulation of VEGF in many diverse cell types including keratocytes [101], microvascular endothelial cells in hypoxic brain [102], chondrocytes [103] and Müller cells [104].…”

Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 58%

“…Glucocorticoids show most of their effects in the cell through activation of GRs by binding specific ligands, glucocorticoid hormones and dexamethasone [98]. In this experimental study, RU486, which are a GR antagonist, completely inhibited Ang-1 and VEGF regulation induced by dexamethasone through GR [97]. What is known is that the activated GR shows its effects through gene transcription [98,99].…”

Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 72%

“…In the same study, RU486 reduced the angiopoetin-1 and VEGF regulation induced by dexamethasone. Again in the same study, no changes were seen on angiopoetin-1 and VEGF mRNA stability, suggesting that dexamethasone regulated angiopoetin-1 and VEGF through transcription [97]. Glucocorticoids show most of their effects in the cell through activation of GRs by binding specific ligands, glucocorticoid hormones and dexamethasone [98].…”

Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 81%

“…In this study, it has been shown that dexamethasone down-regulates Ang-1, which is a potent stabilizer of the blood-brain barrier, and VEGF, which is a potent permeability increaser, down-regulates in similar ways. [97].…”

Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 99%

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Signal Transduction Pathways in use of Dexamethasone Implant in the Eye

Cevik¹,

Küçük²,

Acar³

et al. 2015

SOJI

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Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 58%

Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 72%

Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 81%

Section: Several Forms Of Vegf Have Been Defined: Vegf-a Vegf-b Vegmentioning

confidence: 99%

See 2 more Smart Citations

Signal Transduction Pathways in use of Dexamethasone Implant in the Eye

Cevik¹,

Küçük²,

Acar³

et al. 2015

SOJI

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“…Além disso, segundo Feng et al (2009) a dexametasona nas doses de 0,5 e 1mg/kg, doses equivalentes à da presente pesquisa, estimulam a expressão dos fatores de desenvolvimento do epitélio vascular (VEGF). Em adição, Kim et al (2008a) e Kim et al (2008b) relataram que a dexametasona estimula a angiopoetina, hormônio que ativa os fatores VEGF, o qual, segundo Ferrara (2004) é um potente estimulador da angiogênese induzindo a permeabilidade vascular e aumento do fator de crescimento placentário.…”

Section: Discussionunclassified

Histoquímica e morfometria da placenta de ratas tratadas com dexametasona

et al. 2014

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Pesq. Vet. Bras. 34(7):703-708, julho 2014 703 RESUMO.-A dexametasona, um glicocorticóide sintético, tem a capacidade de atravessar a placenta aumentando o nível de circulação de corticosteróides da mãe para o feto durante a prenhez. Quando administrada nas fases finais da prenhez pode produzir efeitos indesejáveis na formação da placenta e em vários órgãos da prole. Assim, o presente estudo objetivou investigar o efeito da administração da dexametasona (0,8mg/dia/animal) nos cinco primeiros dias da prenhez, sobre o desenvolvimento placentário de ratas. Utilizou-se 30 ratas albinas, divididas em dois grupos: Grupo I -ratas prenhes sem aplicação de dexametasona, sacrificadas ao 7 o e 14 o dia; Grupo II -ratas submetidas à aplicação de dexametasona nos cinco primeiros dias de prenhez, sacrificadas ao 7 o e 14 o dia. Os resultados mostraram que a dexametasona não afetou o número e a histologia dos sítios de implantação, porém, promoveu alteração no disco placentário ocasionando hipertrofia na camada de células trofoblásticas gigantes. Não foram evidenciadas alterações no teor de colágeno, porém houve interferência no metabolismo do glicogênio no espongiotrofoblasto trofospongio. Na morfometria de linhas houve diferença entre os grupos na região de labirinto e células trofoblásticas gigantes, porém a morfometria de pontos só ratificou as alterações percebidas na região do labirinto. The dexamethasone, a synthetic glucocorticoid, has the ability to cross the placenta by increasing the level of movement of corticosteroids from mother to fetus during pregnancy. When administered in the late stages of pregnancy can produce effects undesirable on placental formation. The present study aimed to investigate the effect of administration of dexamethasone (0.8mg/day/animal) in the first five days of pregnancy, on placental development in rats. We used 30 albino rats, divided into two groups: Group I -pregnant rats without the application of dexamethasone, sacrificed to the 7 th and 14 th day. Group II -rats subjected to the application of dexamethasone in the first five days of pregnancy, sacrificed to the 7 th and 14 th day. The results showed that dexamethasone did not affect the number and histology of the implantation sites, but promoted changes in the disk placental causing hypertrophy in trophoblastic giant cell layer. No changes were found in the content of collagen, but there was interference with the metabolism of glycogen in spongiotrophoblast. The morphometry of lines showed, a difference between groups in the region of labyrinth and trophoblast giant cell. However, in morphometry of points there was a difference between groups in the region of labyrinth.INDEX TERMS: Dexamethasone, placenta, histochemical morphometry, rat.

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Oncologic Emergencies

Lewis

Moynihan

2017

The American Cancer Society's Principles of Oncology

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Dexamethasone coordinately regulates angiopoietin-1 and VEGF: A mechanism of glucocorticoid-induced stabilization of blood–brain barrier

Cited by 119 publications

References 33 publications

Signal Transduction Pathways in use of Dexamethasone Implant in the Eye

Signal Transduction Pathways in use of Dexamethasone Implant in the Eye

Histoquímica e morfometria da placenta de ratas tratadas com dexametasona

Oncologic Emergencies

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