Dexamethasone combined with other antiemetics for prophylaxis after laparoscopic cholecystectomy

Abstract

Dexamethasone combined with other antiemetics was significantly better than single antiemetics for prophylaxis of PONV in patients undergoing LC, without apparent side effects.

Effects of dexamethasone on quality of recovery following vaginal surgery: a randomized trial

“…8,9,11,12 Additionally dexamethasone added to antiemetics for chemotherapy prophylaxis shows superior results 6,7 Similar to these studies, we noted less symptoms of PONV as recorded on the VAS scale, and less use of rescue antiemetics for severe symptoms. Although the PONV scale scores did not show a difference, there were very few with clinically important nausea and vomiting overall.…”

“…5 Due to the robust impact of dexamethasone, it has been suggested that all patients undergoing surgery should be considered candidates for this treatment. Indeed, dexamethasone has been evaluated in conjunction with both regional and general anesthesia prior to cesearean section, 8 laparoscopic cholecystectomy, and ambulatory gynecology surgery, [9][10][11][12] with improvements in M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 7 with minimal side effects and risks. 11 In conjunction with other medications, dexamethasone may be part of a multimodal treatment plan that could enhance symptom control.…”

“…Indeed, dexamethasone has been evaluated in conjunction with both regional and general anesthesia prior to cesearean section, 8 laparoscopic cholecystectomy, and ambulatory gynecology surgery, [9][10][11][12] with improvements in M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 7 with minimal side effects and risks. 11 In conjunction with other medications, dexamethasone may be part of a multimodal treatment plan that could enhance symptom control. 13 Vaginal reconstructive surgery for pelvic organ prolapse is a common and minimally invasive procedure, with most patients being discharged on postoperative day one (POD#1).…”

“…10 Other influence is by 5-hydoxytryptamine (serotonin, 5-HT) turnover in the neural tissue, prevention of release of 5-HT in the gastrointestinal system and potentiation centrally of other antiemetic effects. 11 Moreover, diminished use of narcotic may improve awareness while reduced vomiting leads to less diaphragmatic excursion and pressure in the abdominal area. We noted improvements in the QoR emotional state domain, which is reflective of the impact of dexamethasone.…”

A comparative study of ondansetron and granisetron in combination with dexamethasone-in prophylaxis for postoperative nausea and vomiting (PONV) in laproscopic cholecystectomies

“…10 The mechanism of action of corticosteroids is unknown but may be related to inhibition of prostaglandin synthesis, decrease in 5HT3 levels in central nervous system and in the gut or by an anti-inflammatory action at operative sites. 11 Gregory et al reported the effectiveness of 5HT3 antagonists in prevention of chemotherapy induced nausea and vomiting. 9,12 5HT3 anatagonists are the first line therapy in prevention of PONV.…”