Perioperative intravenous dexamethasone for patients undergoing colorectal surgery: a systematic review and meta-analysis

McKechnie, Tyler; Elder, Geoffrey C. B.; Ichhpuniani, Simarpreet; Chen, Andrew T.; Logie, Kathleen; Doumouras, Aristithes G.; Hong, Dennis; Benko, Randy; Eskicioglu, Cagla

doi:10.1007/s00384-023-04327-7

Cited by 4 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intravenous prophylaxis with dexamethasone has also been used in dental surgery 12 and has proven to be a safe and effective method for significantly reducing the need for analgesics in the postoperative period. Similar doses of intravenously administered dexamethasone immediately before the surgical procedure reduced the analgesic requirements in patients undergoing colorectal surgery 13 .…”

Section: Discussionmentioning

confidence: 94%

Impact of Dexamethasone on the stress response during perioperative management of elderly patients with hip fracture

Šakić,

Šakić-Zdravčević

2023

Galenika Med J

View full text Add to dashboard Cite

Introduction: Hip fracture is the most common cause of emergency hospital admissions among the elderly population and is associated with high postoperative morbidity. The hypothesis is that a single intrathecal dose of Dexamethasone with Levobupivacaine for surgical correction of hip fracture reduces surgical stress and contributes to better treatment outcomes. Method: Elderly patients with hip fracture who underwent surgery under spinal anesthesia with Levobupivacaine were analyzed, with one group receiving a single intrathecal dose of Dexamethasone and the other group serving as a control (group DLSA/control group LSA). The following variables were monitored: gender, type of injury, cortisol levels, time elapsed from injury to surgical intervention, pain intensity, occurrence of delirium, postoperative cognitive deficits and other complications, length of hospital stay, and mortality. Results: Reduced cortisol concentrations, prolonged analgesia duration, and shorter hospitalization duration were observed in DLSA group, compared to the LSA group. Conclusion: A single intrathecal injection of Dexamethasone in spinal anesthesia for surgical correction of hip fracture reduces perioperative stress response by lowering plasma cortisol concentration, providing a longer analgesic effect, reducing the incidence of delirium and POCD (Postoperative Cognitive Dysfunction), and improving rehabilitation prospects. This leads to a shorter hospitalization duration, justifying this anesthetic approach as a recommended method of choice.

show abstract

Section: Discussionmentioning

confidence: 94%