Dexa Body Composition Assessment in 10-11 Year Healthy Children

Verduin, Wouter M.; Helder, R. Van Den; Doodeman, Hiëronymus J.; Struijf, E.; Houdijk, Alexander P. J.

doi:10.1371/journal.pone.0165275

Cited by 21 publications

(20 citation statements)

References 35 publications

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“…For example, we used only BMI score as a measure of obesity status. There have been multiple recent reports that BMI may not be the most ideal measurement of body composition; hence, other obesity metrics, such as waist circumference or dual-energy x-ray absorptiometry scanning, may give a more in-depth understanding of obesity and its effects on tumor immunity in sarcoma patients ( 39 – 41 ). Furthermore, we had a limited number of samples ( n = 50) and included multiple sarcoma subtypes in our cohort, likely increasing variability in our results.…”

Section: Discussionmentioning

confidence: 99%

Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects

et al. 2017

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Sarcomas are a rare but fatal tumor type that accounts for <1% of adult solid malignancies and ~15% of childhood malignancies. Although the use of immunotherapy is being actively investigated for other solid tumors, advances in immunotherapy for sarcoma patients are lacking. To better understand the systemic immune environment in sarcoma patients, we performed a detailed multiplex analysis of serum cytokines, chemokines, and protumorigenic factors from treatment-naive subjects with localized, high-grade sarcoma. Because obesity is a major healthcare issue in the United States, we additionally examined the effects of obesity on serum protein profiles in our sarcoma subject cohort. We found that the systemic host environment is profoundly altered to favor tumor progression, with epidermal growth factor, angiopoietin-2, vascular endothelial growth factor A, IL-6, IL-8, and MIP-1β all increased relative to tumor-free controls (all p < 0.05). Surprisingly, we found that obesity did not exacerbate this protumorigenic profile, as epidermal growth factor and IL-8 decreased with increasing subject body mass index (both p < 0.05 versus normal or overweight subjects). The Th2-related cytokines IL-4, IL-5, and IL-13 were also decreased in the presence of obesity. Thus, although the systemic environment in sarcoma subjects favors tumor progression, obesity does not further aggravate the production of protumorigenic factors.

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Section: Discussionmentioning

confidence: 99%

Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects

et al. 2017

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“…DEXA is the most suitable method to measure body fat in the general population. This method measures adipose tissue with great accuracy, safe low radiation, and short scanning time [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Comparisons of Waist Circumference Measurements at Five Different Anatomical Sites in Chinese Children

Yang

Wang

2017

BioMed Research International

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This study compared the waist circumference (WC) measurements of Chinese children at different sites to determine the relationship between WC measurements and body fat. WC was measured at five sites in 255 subjects aged 9–19 years: immediately below the lowest rib (WC1), at the narrowest waist (WC2), the midpoint between the lowest rib and the iliac crest (WC3), 1 cm above the umbilicus (WC4), and immediately above the iliac crest (WC5). Body fat mass (FM), body fat percentage (% BF), body fat mass in the trunk (FM in the trunk), and fat percentage in the trunk (% BF in the trunk) were determined by dual-energy X-ray absorptiometry. The WCs were then compared through ANOVA with repeated measurement. The relationship of WC of each site with FM, % BF, FM in the trunk, and % BF in the trunk was examined through partial correlation. The WCs exhibited the following pattern: WC2 < WC1 < WC3 < WC4 < WC5 (p < 0.001) in males and WC2 < WC1 < WC4, WC3 < WC5 (p < 0.001) in females. The measured WCs were strongly correlated with FM, % BF, FM in the trunk, and % BF in the trunk. The WC measurements at five commonly used sites among Chinese children are different from one another. Results indicate that standardizing the anatomic point for the WC measurements is necessary.

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“…Evaluating body composition in children and adolescents is a useful component of weight control and exercise programs . The information gathered from these body composition assessments can be used by health care workers to refine their lifestyle recommendations.…”

Section: Introductionmentioning

confidence: 99%

Children and Adolescents’ Anthropometrics Body Composition from 3‐D Optical Surface Scans

Wong

Kennedy

et al. 2019

Obesity

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Objective This study aimed to explore the accuracy and precision of three‐dimensional optical (3DO) whole‐body scanning for automated anthropometry and estimating total and regional body composition. Methods Healthy children and adolescents (n = 181, ages 5‐17 years) were recruited for the Shape Up! Kids study. Each participant underwent whole‐body dual‐energy x‐ray absorptiometry and 3DO scans; multisite conventional tape measurements served as the anthropometric criterion measure. 3DO body shape was described using automated body circumference, length, and volume measures. 3DO estimates were compared with criterion measures using simple linear regression by the stepwise selection method. Results Of the 181 participants, 112 were used for the training set, 49 were used for the test set, and 20 were excluded for technical reasons. 3DO body composition estimates were strongly associated with dual‐energy x‐ray absorptiometry measures for percent body fat, fat mass, and fat‐free mass (R2: 0.83, 0.96, and 0.98, respectively). 3DO provided reliable measurements of fat mass (coefficient of variation, 3.30; root mean square error [RMSE], 0.53), fat‐free mass (coefficient of variation, 1.34; RMSE, 0.53 kg), and percent body fat (RMSE = 1.2%). Conclusions 3DO surface scanning provides accurate and precise anthropometric and body composition estimates in children and adolescents with high precision. 3DO is a safe, accessible, and practical method for evaluating body shape and composition in research and clinical settings.

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Dexa Body Composition Assessment in 10-11 Year Healthy Children

Cited by 21 publications

References 35 publications

Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects

Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects

Comparisons of Waist Circumference Measurements at Five Different Anatomical Sites in Chinese Children

Children and Adolescents’ Anthropometrics Body Composition from 3‐D Optical Surface Scans

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