Deviance detection is the dominant component of auditory contextual processing in the lateral superior temporal gyrus: A human ECoG study

Ishishita, Yohei; Kunii, Naoto; Shimada, Sohei; Ibayashi, Kenji; Tada, Mariko; Kirihara, Kazuhiro; Kawai, Kensuke; Uka, Takanori; Kasai, Kiyoto; Saito, Nobuhito

doi:10.1002/hbm.24438

Cited by 33 publications

(19 citation statements)

References 43 publications

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“…Abnormalities are more frequently reported in the STG and MTG than in other parts of the auditory cortex in neuroimaging studies of tinnitus (Boyen et al, 2013;Chen et al, 2014;Han et al, 2018a). The temporal gyrus is critical for auditory processing that includes simple auditory stimulus processing and semantic memory (May and Tiitinen, 2010;Recasens et al, 2014), and is a connection in the hierarchical structure of the primary auditory cortex and frontal lobe (Ishishita et al, 2019). Our results revealed abnormal brain responses in this region, suggesting their involvement in tinnitus.…”

Section: Discussionmentioning

confidence: 53%

A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus

Cheng

Zhou

et al. 2020

Front. Hum. Neurosci.

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Brain imaging studies of tinnitus patients have revealed marked changes in brain structure and function, but there are inconsistencies in those findings. In this meta-analysis, we investigated concurrence across studies to clarify those abnormalities in brain structure and function in tinnitus. Neuroimaging studies published up to December 6, 2019 were searched in the PubMed, Web of Science, EMBASE, and Cochrane Library databases, Chinese Nation Knowledge Infrastructure, Chinese Biomedical Literature Database, the Chongqing VIP, and Wanfang Database. Study selection, quality assessment, and data extraction were performed by two independent researchers. Anisotropic effect size signed differential mapping (AES-SDM) was used to perform a multimodal analysis of available studies reporting whole-brain structural or functional data in tinnitus patients. There were 14 studies that met the inclusion criteria. The structural dataset comprised 242 tinnitus patients and 217 matched healthy subjects (HS), while the functional dataset included 130 tinnitus patients and 140 matched HS. Our analysis revealed structural alterations in the superior temporal gyrus, middle temporal gyrus (MTG), angular gyrus, caudate nucleus, superior frontal gyrus, and supplementary motor area, as well as functional differences in the MTG, middle occipital gyrus, precuneus, and right inferior parietal (excluding supramarginal and angular) gyri. The multimodal analysis revealed significant differences in the right MTG of tinnitus patients relative to HS. These findings suggest the involvement of the cortico-striatal circuits in the neuropathology of tinnitus.

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Section: Discussionmentioning

confidence: 53%

A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus

Cheng

Zhou

et al. 2020

Front. Hum. Neurosci.

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“…In a human ECoG study, we have previously demonstrated that high gamma oscillation induced by the mismatch paradigm was widely distributed in the superior temporal gyrus, rather than within a limited area adjacent to the Sylvian fissure. Furthermore, mismatch response was shown to be attributable to deviance detection rather than adaptation (23). N1 adaptation did not account for the characteristics of the mismatch response.…”

Section: Introductionmentioning

confidence: 82%

Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study

et al. 2020

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Auditory mismatch negativity (MMN) is an electrophysiological response to a deviation from regularity. This response is considered pivotal to understanding auditory processing, particularly in the pre-attentive phase. However, previous findings suggest that MMN is a product of N1 adaptation/enhancement, which reflects lower-order auditory processing. The separability of these two components remains unclear and is considered an important issue in the field of neuroscience. The aim of the present study was to spatiotemporally differentiate MMN from N1 adaptation using human electrocorticography (ECoG). Auditory evoked potentials under the classical oddball (OD) task as well as the many standards (MS) task were recorded in three patients with epilepsy whose lateral cortices were widely covered with high-density electrodes. Close observation identified an electrode at which N1 adaptation was temporally separated from MMN, whereas N1 adaptation was partially incorporated into MMN at other electrodes. Since N1 adaptation occurs in the N1 population, we spatially compared MMN with N1 obtained from the MS task instead of N1 adaptation. As a result, N1 was observed in a limited area around the Sylvian fissure adjacent to A1, whereas MMN was noted in wider areas, including the temporal, frontal, and parietal lobes. MMN was thus considered to be differentiated from N1 adaptation. The results suggest that MMN is not merely a product of the neural adaptation of N1 and instead represents higher-order processes in auditory deviance detection. These results will contribute to strengthening the foundation of future research in this field.

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“…MMN can also be measured with electrocorticography (ECoG), which has high spatial resolution. Investigation of ECoG with various paradigms is useful for identifying the precise location of neural circuits underlying MMN in various paradigms (52). In addition, MMN is used as a biomarker for clinical trials (53,54).…”

Section: Discussionmentioning

confidence: 99%

A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia

et al. 2020

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Mismatch negativity (MMN) is a widely used biological marker for schizophrenia research. Previous studies reported that MMN amplitude was reduced in schizophrenia and that reduced MMN amplitude was associated with cognitive impairments and poor functional outcome in schizophrenia. However, the neurobiological mechanisms underlying the reduced MMN amplitude remain unclear. Recent studies suggest that reduced MMN amplitude may reflect altered predictive coding in schizophrenia. In this paper, we reviewed MMN studies that used new paradigms and computational modeling to investigate altered predictive coding in schizophrenia. Studies using the roving oddball paradigm and modified oddball paradigm revealed that the effects of conditional probability were impaired in schizophrenia. Studies using omission paradigms and many-standards paradigms revealed that prediction error, but not adaptation, was impaired in schizophrenia. A study using a local-global paradigm revealed that hierarchical structures were impaired at both local and global levels in schizophrenia. Furthermore, studies using dynamic causal modeling revealed that neural networks with hierarchical structures were impaired in schizophrenia. These findings indicate that altered predictive coding underlies the reduced MMN amplitude in schizophrenia. However, there are several unsolved questions about optimal procedures, association among paradigms, and heterogeneity of schizophrenia. Future studies using several paradigms and computational modeling may solve these questions, and may lead to clarifying the pathophysiology of schizophrenia and to the development of individualized treatments for schizophrenia.

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Deviance detection is the dominant component of auditory contextual processing in the lateral superior temporal gyrus: A human ECoG study

Cited by 33 publications

References 43 publications

A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus

A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus

Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study

A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia

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