A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus

Cheng, Shirui; Xu, Guixing; Zhou, Jun; Qu, Yuzhu; Li, Zhengjie; He, Zhaoxuan; Yin, Tao; Ma, Peihong; Liang, Fanrong

doi:10.3389/fnhum.2020.00028

Cited by 36 publications

(36 citation statements)

References 59 publications

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“…In addition, in recent research performed before and after 12 weeks of sound therapy in tinnitus patients, our team also found that there were more changes in functional connectivity (Lv et al, 2020). A multimodal neuroimaging meta-analysis investigated the neural substrates of tinnitus by combining information from whole-brain VBM studies of GM volume of and ReHo studies of spontaneous brain activity (Cheng et al, 2020). It reported that increased volume of GM in the bilateral STG, right middle temporal gyrus (MTG), and right supramarginal gyrus and decreased GM volume in the bilateral hypothalamus, left superior frontal gyrus (SFG), and right occipital lobe were observed in tinnitus patients (Boyen et al, 2013).…”

Section: Discussionmentioning

confidence: 93%

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Xuan

Wang

et al. 2020

Front. Neurosci.

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According to previous studies, many neuroanatomical alterations have been detected in patients with tinnitus. However, few studies have reported on the morphological changes observed following sound therapy. To explore the brain anatomical alterations in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis before and after effective 12 weeks sound therapy. The protocol was registered on ClinicalTrials.gov, ID: NCT02774122. In this study, we collected data from 27 matched healthy control (HC) individuals and 27 idiopathic tinnitus patients before and after 12 weeks of sound therapy by using adjusted narrow band sound. 3.0T MRI system and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Mann-Whitney U Test, Wilcoxon Signed-Ranks test, and Pearson's correlation analysis were used in the statistical analysis. We found significantly decreased gray matter (GM) volume in the left thalami, right thalami, and cochlear nucleus among the tinnitus patients before sound therapy (baseline) compared to the HC group. However, we did not find significant differences in brain regions between the 12-week treatment and HC groups. According to the results of Wilcoxon Signed-Ranks test, the 12-week sound therapy group demonstrated significant greater brain volume compared with the baseline group among these brain regions. Decreased THI score and changed GM volume were not correlated. This is a useful study for observing the characteristics of neuroanatomical changes in patients with idiopathic tinnitus before and after sound treatment. The study characterized the effect of sound therapy on brain volume. It found that sound therapy had a normalizing effect on the bilateral thalami and cochlear nucleus.

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Section: Discussionmentioning

confidence: 93%

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Xuan

Wang

et al. 2020

Front. Neurosci.

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“…The tinnitus comorbid with headache may lead to more complex dysfunction in the cortico-limbic network. Moreover, prior fMRI researches have revealed the associations between aberrant neuronal activity and functional connectivity of the STG and tinnitus distress [30][31][32][33][34]. However, Emmert et al found no significant CBF alterations within the auditory cortex in tinnitus patients using ASL [15], partly due to a small sample size (n = 14).…”

Section: Discussionmentioning

confidence: 99%

Headache is associated with aberrant cerebral blood flow in chronic tinnitus revealed by perfusion functional MRI

Chen¹,

Hu²,

Cui³

et al. 2020

Preprint

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Background: Chronic tinnitus is often accompanied with headache symptom that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between headache and tinnitus remains unclear. This study will investigate whether aberrant CBF patterns exist in chronic tinnitus patients and examine the influence of headache on CBF alterations in chronic tinnitus. Methods: Participants included chronic tinnitus patients (n=45) and non-tinnitus controls (n=50), matched for age, sex, education, and hearing thresholds. CBF images were collected and analyzed using arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between tinnitus patients and non-tinnitus controls were first detected. The interaction effects between headache and tinnitus for CBF alterations were further examined. Correlation analyses illustrated the association between CBF values and tinnitus severity as well as between CBF and degree of headache.Results: Compared with non-tinnitus controls, chronic tinnitus patients exhibited decreased CBF, primarily in right superior temporal gyrus (STG), bilateral middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); decreased CBF in these regions was correlated with tinnitus distress. There was a significant interaction effect between headache and tinnitus for CBF in right STG and MFG. Moreover, the degree of headache correlated negatively with CBF in tinnitus patients.Conclusions: Chronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Headache may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with headache.

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“…A reduction of at least 16 points in the THI score was considered effective treatment (41). 27 The HC group was not given any kind of sound during the study.…”

Section: Sound Therapy and Clinical Evaluationmentioning

confidence: 99%

“…Previous studies have mentioned functional issues but performed fewer structural analyses (39,57). There are structural changes in tinnitus patients, and these structural changes will affect structure after treatment (27); therefore, it is necessary to pay more attention to the structural changes associated with tinnitus patients. The results of this study are important supplements to original research.…”

Section: Auditory-related Brain Structural Alterations and Network Pementioning

confidence: 99%

“…Currently, VBM has been used increasingly widely to describe microstructural changes in the brain in tinnitus patients (25,26). A meta-analysis revealed structural alterations in the brain of tinnitus patients in the superior temporal gyrus, middle temporal gyrus (MTG), angular gyrus, caudate nucleus, superior frontal gyrus, and supplementary motor area (27). Our previous study also showed that compared with normal controls, patients with unilateral pulsatile tinnitus have a signi cantly increased gray matter (GM) volume in the bilateral superior temporal gyri (28).…”

Section: Introductionmentioning

confidence: 99%

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Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

Qian

et al. 2020

Preprint

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Background: Many neuroanatomical alterations have been detected in patients with tinnitus in previous studies. However, little is known about morphological and structural covariance network (SCN) changes before and after long-term sound therapy. This study aimed to explore alterations in brain anatomical and SCN changes in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis 24 weeks before and after sound therapy. Methods: Thirty-three tinnitus patients underwent magnetic resonance imaging scans at baseline and after 24 weeks of sound therapy. Twenty-six age- and sex-matched healthy control (HC) individuals also underwent two scans over a 24-week interval; 3.0T MRI and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Two-way mixed model analysis of variance (ANOVA) and post hoc analyses were performed to determine differences between the two groups (patients and HCs) and between the two scans (at baseline and at the 24th week). Two-sample t tests, paired-samples t tests, and Pearson’s correlation analysis were used in the post hoc analysis.Results: Interaction effects between the two groups and the two scans demonstrated significantly different gray matter (GM) volume in the right parahippocampus gyrus, right caudate, left superior temporal gyrus, left cuneus gyrus and right calcarine gyrus; we found significantly decreased GM volume in the above five brain regions among the tinnitus patients before sound therapy (baseline) compared to that in the HC group. The 24-week sound therapy group demonstrated significantly greater brain volume compared with the baseline group among these brain regions. We did not find significant differences in brain regions between the 24-week sound therapy and HC groups. The SCN results showed that the left superior temporal gyrus and left rolandic operculum were significantly different in nodal efficiency, nodal degree centrality and nodal betweenness centrality after FDR correction. Decreased THI scores and GM volume changes between the left thalamus and right thalamus were not correlated. Conclusions: This study characterized the effect of sound therapy on brain GM volume, especially in the left superior temporal lobe. Notably, sound therapy had a normalizing effect on tinnitus patients.

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A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus

Cited by 36 publications

References 59 publications

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Headache is associated with aberrant cerebral blood flow in chronic tinnitus revealed by perfusion functional MRI

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

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