Devenir à long terme des malades opérés et traités pour échinococcose alvéolaire

Charbonnet, Pierre; Bühler, Léo H.; Sagnak, E; Villiger, Peter M.; Morel, Philippe; Mentha, Gilles

doi:10.1016/j.anchir.2004.01.017

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…Since LAE cannot be easily detected in the early clinical stage, Echinococcus parasites have typically already widely invaded intrahepatically and extrahepatically when obvious liver function impairment is found ( 8 , 9 ). As a result, the radical resection rate associated with LAE has been low ( 10 ), and, if the condition is not treated, the 10-year mortality rate can be as high as 93%.…”

Section: Discussionmentioning

confidence: 99%

“…As a treatment option for advanced LAE, autologous liver transplantation (ALT) has been increasingly carried out in recent years. Effectively determining the indications and surgical timing for LAE-ALT and detecting post-ALT recurrence and metastasis as early as possible is the significant clinical value of ALT as a treatment for LAE ( 8 ). In vitro , hepatic resection plus ALT could be an ideal choice for end-stage LAE radical treatment.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the clinical value of 18F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation

Qin

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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The aim of this study was to evaluate the clinical value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in advanced liver alveolar echinococcosis (LAE) prior to and following autologous liver transplantation (ALT). The biodistribution of lesions in 8 patients was recorded using 18F-FDG PET/CT prior to and following surgery. The maximum standardized uptake value (SUVmax) of the lesions was also measured and compared with the pathological results. The overall hepatic peri-lesion SUVmax of the patients was 3.57±1.21, and the delayed SUVmax was 4.19±1.70. The diagnostic sensitivity of 18F-FDG PET/CT in LAE was 91.67%, with a specificity of 60.00% and accuracy of 82.35%. The positive predictive value was 84.62%, and the negative predictive value was 75.00%. SUVmax values of the surviving liver were 1.23±0.78 after 1 month, 1.15±0.67 after 3 months and 0.85±0.35 after 6 months. Compared with normal liver values (0.95±0.19), the 1-month SUVmax was significantly different. The SUVmax in 3 patients with high-lividity lesions was 2.05±0.72, and the delayed SUVmax was 3.15±0.83; 3 months after transplantation, the SUVmax was 1.85±0.62, and the delayed SUVmax was 2.95±0.79, revealing no significant difference. In conclusion, 18F-FDG PET/CT is effective for determining the biological boundary of LAE and shows important clinical value in determining the metabolic activities of the surviving liver following ALT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of the clinical value of 18F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation

Qin

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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“…Les options présentées ici reprennent les conclusions de cette réunion. Le traitement par albendazole (Eskazole W ) est le dénominateur commun de toutes les options thérapeutiques [39]. Il est a priori toujours indiqué.…”

Section: Et Il Est Confirmé Par La Sérologie Spécifiqueunclassified

“…En cas d'intolérance avérée à l'albendazole (leucopénie ou augmentation des aminotransférases persistant malgré un dosage d'albendazole sulfoxyde dans l'intervalle thérapeutique), il est possible de recourir au mébendazole (Vermox W ), médicament de la même famille, à la biodisponibilité encore moins grande que l'albendazole et qui n'a pas l'AMM en France. L'ablation chirurgicale complète de la tumeur parasitaire reste la règle chaque fois qu'elle apparaît possible [39,40]. Une analyse rétrospective de 117 cas pris en charge au CHU de Besançon entre 1972 et 1993 a montré que les résections curatives avaient concerné 24 % des malades traités dans la période la plus récente de cette étude (1983)(1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993).…”

Section: Et Il Est Confirmé Par La Sérologie Spécifiqueunclassified

Échinococcose alvéolaire : d’une maladie rurale incurable à une infection urbaine sous contrôle ?

et al. 2010

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“…An inadequate adherence to chemotherapy, due to adverse side effects, can explain the relapsing spread of AE and a worsening general condition of patients with severe E. multilocularis infiltrations [15, 16]. Considering these circumstances, the rising numbers of reported cases of AE especially in Europe and the lack of a curative drug treatment, emphasizes the necessity to further investigate the mechanisms underlying this threat and search for improved therapeutic options [17-22].…”

Section: Introductionmentioning

confidence: 99%

Albendazole reduces endoplasmic reticulum stress induced byEchinococcus multilocularisin mice

Weingärtner

Jebbawi

et al. 2021

Preprint

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Background Echinococcus multilocularis causes alveolar echinococcosis (AE), a rising zoonotic disease in the northern hemisphere. Treatment of this fatal disease is limited to chemotherapy using benzimidazoles and surgical intervention, with relatively frequent disease recurrence in cases without radical surgery. Elucidating the molecular mechanisms underlying E. multilocularis infections and host-parasite interactions aids developing novel therapeutic options. This study explored an involvement of unfolded protein response (UPR) and endoplasmic reticulum-stress (ERS) during E. multilocularis infection in mice. Methods E. multilocularis- and mock-infected C57BL/6 mice were subdivided six weeks after infection into vehicle and albendazole (ABZ) treated groups. Eight weeks later, liver tissue was collected to examine mRNA, microRNA (miR) and protein expression of UPR- and ERS-related genes. Results E. multilocularis infection upregulated UPR- and ERS-related proteins, including ATF6, CHOP, GRP78, ERP72, H6PD and calreticulin, whilst PERK and its target eIF2α were not affected, and IRE1α and ATF4 were downregulated. ABZ treatment in E. multilocularis infected mice reversed the increased ATF6 and calreticulin protein expression, tended to reverse increased CHOP, GRP78, ERP72 and H6PD expression, and decreased ATF4 and IRE1α expression to levels seen in mock-infected mice. The expression of miR-146a-5p (downregulated by IRE1α) and miR-1839-5p (exhibiting a unique target site in the IRE1α 3’UTR) were significantly increased in E. multilocularis infected mice, an effect reversed by ABZ treatment. Other miRs analyzed were not altered in E. multilocularis infected mice. Conclusions and Significance AE causes UPR activation and ERS in mice. The E. multilocularis -induced ERS was ameliorated by ABZ treatment, indicating its effectiveness to inhibit parasite proliferation and downregulate its activity status. ABZ itself did not affect UPR in control mice. Identified miR-146a-5p and miR-1839-5p might represent biomarkers of E. multilocularis infection. Modulation of UPR and ERS, in addition to ABZ administration, could be exploited to treat E. multilocularis infection.

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Devenir à long terme des malades opérés et traités pour échinococcose alvéolaire

Cited by 10 publications

References 19 publications

Analysis of the clinical value of 18F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation

Analysis of the clinical value of 18F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation

Échinococcose alvéolaire : d’une maladie rurale incurable à une infection urbaine sous contrôle ?

Albendazole reduces endoplasmic reticulum stress induced byEchinococcus multilocularisin mice

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