2018
DOI: 10.1080/15548627.2018.1454569
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Developmentally regulated autophagy is required for eye formation in Drosophila

Abstract: A c c e p t e d M a n u s c r i p t Billes et al., 2018., Revision 3 Autophagy in eye development 3 microtubule-associated protein 1 light chain 3; MF, morphogenetic furrow; PE, Tables (S1, S2), and Suppl. Figures and Figure Legends (S1 to S31).A c c e p t e d M a n u s c r i p t

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Cited by 20 publications
(15 citation statements)
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References 101 publications
(90 reference statements)
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“…These findings demonstrate that unbalanced autophagy turnover is responsible for retinal damage and functional alterations caused by defective full-length dystrophin. Previous reports in D. melanogaster suggest that cell death-suppressing and differentiating effects of autophagy are required for eye formation [ 86 ]. In addition, defects in the autophagic pathway of Drosophila photoreceptors are shown at the basis of retinal degeneration [ 87 ].…”
Section: Discussionmentioning
confidence: 99%
“…These findings demonstrate that unbalanced autophagy turnover is responsible for retinal damage and functional alterations caused by defective full-length dystrophin. Previous reports in D. melanogaster suggest that cell death-suppressing and differentiating effects of autophagy are required for eye formation [ 86 ]. In addition, defects in the autophagic pathway of Drosophila photoreceptors are shown at the basis of retinal degeneration [ 87 ].…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, typical hallmarks of neuroretina degeneration, for instance, vacuoles and damaged mitochondria, were not detectable at the ultrastructural level in eye neurons. Cell death-suppressing and differentiating effects of autophagy are required for Drosophila eye formation [ 51 ]. Also, defects in the autophagic pathway of Drosophila photoreceptors were involved in retinal degeneration [ 52 ].…”
Section: Discussionmentioning
confidence: 99%
“…RNAi lines against the following genes are from the TRiP collection at Harvard Medical School and were obtained from the BDSC: egfp (#41556); dredd (#34070); 85 dnaseII (#63635)*; dor (#44426)*; car (#34007); 86 parp1 (#57265); 87 cathB (#33953); 88 cathL (#41939); 89 atm (#44417)*; chk2 (#64482); 90 atr (#41934); 90 chk1 (#36685); 90 atg7 (#34369); 91 atg6 (#35741); 91 atg5 (#34899); 92 atg8a (#34340); 92 duox (#32903); 93 orc2 (#43215)*; cyp1 Ri1 (#33950); 94 cyp1 Ri2 (#33001)*; CG17266 (#58350)*; CG2852 (#55196)*.…”
Section: Methodsmentioning
confidence: 99%