1996
DOI: 10.1006/faat.1996.0189
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Developmental Toxicity of PCB 126 (3,3′,4,4′,5-Pentachlorobiphenyl) in Nestling American Kestrels (Falco sparverius)

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Cited by 94 publications
(50 citation statements)
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“…Studies have shown kestrels to be susceptible to PCB toxicity; experimental exposure caused moderate hepatic enzyme (CYP1A) induction in adults (Elliot et al 1997), and severe hepatic, thyroid, splenic, and bursal pathology in nestlings (Hoffman et al 1996). The latter findings are consistent with immunomodulation.…”
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confidence: 94%
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“…Studies have shown kestrels to be susceptible to PCB toxicity; experimental exposure caused moderate hepatic enzyme (CYP1A) induction in adults (Elliot et al 1997), and severe hepatic, thyroid, splenic, and bursal pathology in nestlings (Hoffman et al 1996). The latter findings are consistent with immunomodulation.…”
mentioning
confidence: 94%
“…Polychlorinated biphenyls (PCBs) continue to persist as environmental contaminants due to their lipophilic nature and their ability to bioaccumulate and biomagnify in the food chain (Hoffman et al 1996). These are among the numerous compounds that are causing concern because of their potential as endocrine disruptors in (Ankley and Giesy 1998;.…”
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confidence: 99%
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“…They exert Due to their stability and lipophilic character, PCBs persist in the environment and accumulate in fatty tissues of animals and humans (Kimbrough, 1995;Hansen, 1999). PCBs are well known as potential neurotoxic (Seegal et al, 2005), teratogenic, and embriotoxic agents, effecting the embryonic development in fish (Arzuaga et al, 2004), birds (Hoffman et al, 1996;Summer et al, 1996), rodents (Goodwill et al, 2007; Kimura- Kuroda et al, 2007) and humans (Pocar et al, 2006;Roegge and Schantz 2006). PCBs can also contribute to the development of cancer in experimental animals (Carpenter, 2006;Knerr and Schrenk, 2006;Lehmann et al, 2007) and are classified as the probable carcinogens in humans (class 2A carcinogens according to the IARC classification) (Shields, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…The metals cadmium (Bhattacharyya et al, 1988), aluminum (Hahn, 1989;Firling et al, 1999), and lead (Potula et al, 2006) are known to induce harmful effects on bone tissue. Experimental studies suggest that bone tissue could be an important target for a number of endocrine-disrupting persistent organohalogen pollutants, including hexachlorobenzene (Andrews et al, 1988), polychlorinated biphenyls (PCBs) (Andrews, 1989;Hoffman et al, 1996;Lind et al, 1999Lind et al, , 2000Lundberg et al, 2006), and polychlorinated dibenzo-p-dioxins (PCDD) (Jämsä et al, 2001;Miettinen et al, 2005).…”
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confidence: 99%