Developmental Toxicity of PCB 126 (3,3′,4,4′,5-Pentachlorobiphenyl) in Nestling American Kestrels (Falco sparverius)

Hoffman, David J.

doi:10.1006/faat.1996.0189

Cited by 94 publications

(50 citation statements)

References 39 publications

(5 reference statements)

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“…Studies have shown kestrels to be susceptible to PCB toxicity; experimental exposure caused moderate hepatic enzyme (CYP1A) induction in adults (Elliot et al 1997), and severe hepatic, thyroid, splenic, and bursal pathology in nestlings (Hoffman et al 1996). The latter findings are consistent with immunomodulation.…”

mentioning

confidence: 94%

“…Polychlorinated biphenyls (PCBs) continue to persist as environmental contaminants due to their lipophilic nature and their ability to bioaccumulate and biomagnify in the food chain (Hoffman et al 1996). These are among the numerous compounds that are causing concern because of their potential as endocrine disruptors in (Ankley and Giesy 1998;.…”

mentioning

confidence: 99%

“…These are among the numerous compounds that are causing concern because of their potential as endocrine disruptors in (Ankley and Giesy 1998;. Contaminant-induced embryonic mortality and malformation, as well as reduced reproductive success, have been well described in birds exposed to dietary PCBs (Fernie et al 2001a(Fernie et al , 2001bGilbertson et al 1991;Hoffman et al 1996;Kozie and Anderson 1991;Schwartz et al 1993).…”

mentioning

confidence: 99%

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Thyroid Hormone Suppression and Cell-Mediated Immunomodulation in American Kestrels ( Falco sparverius ) Exposed to PCBs

Smits

Fernie

Bortolotti

et al. 2002

Archives of Environmental Contamination and Toxicology

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confidence: 94%

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confidence: 99%

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confidence: 99%

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Thyroid Hormone Suppression and Cell-Mediated Immunomodulation in American Kestrels ( Falco sparverius ) Exposed to PCBs

Smits

Fernie

Bortolotti

et al. 2002

Archives of Environmental Contamination and Toxicology

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“…They exert Due to their stability and lipophilic character, PCBs persist in the environment and accumulate in fatty tissues of animals and humans (Kimbrough, 1995;Hansen, 1999). PCBs are well known as potential neurotoxic (Seegal et al, 2005), teratogenic, and embriotoxic agents, effecting the embryonic development in fish (Arzuaga et al, 2004), birds (Hoffman et al, 1996;Summer et al, 1996), rodents (Goodwill et al, 2007; Kimura- Kuroda et al, 2007) and humans (Pocar et al, 2006;Roegge and Schantz 2006). PCBs can also contribute to the development of cancer in experimental animals (Carpenter, 2006;Knerr and Schrenk, 2006;Lehmann et al, 2007) and are classified as the probable carcinogens in humans (class 2A carcinogens according to the IARC classification) (Shields, 2006).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of PCBs induces proinflammatory and prometastatic responses

Sipka

Eum

Son

et al. 2008

Environmental Toxicology and Pharmacology

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Exposure to specific congeners of polychlorinated biphenyls (PCBs) can induce proinflammatory alterations, which may contribute to the formation of blood-borne tumor metastasis. The main aim of the present study was to establish an experimental model of PCB exposure in which PCBs are administered by oral gavage, which resembles the human exposure through the food chain. To determine structure-function relationship, we studied induction of inflammatory responses in the livers, lungs and brains of mice treated with PCB77 (a major coplanar PCB), PCB104 (a non-coplanar PCB with multiple ortho-chlorine substituents), and PCB153 (a major non-coplanar PCB) after a single gavage dose (150 µmol/kg body weight). The strongest expression of proinflammatory proteins occurred 24 h following the PCB administration independent of the class of PCB congeners. These data indicate that food-chain exposure to PCBs can induce proinflammatory mediators in organs that are potential targets for PCB-induced toxicity.

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“…The metals cadmium (Bhattacharyya et al, 1988), aluminum (Hahn, 1989;Firling et al, 1999), and lead (Potula et al, 2006) are known to induce harmful effects on bone tissue. Experimental studies suggest that bone tissue could be an important target for a number of endocrine-disrupting persistent organohalogen pollutants, including hexachlorobenzene (Andrews et al, 1988), polychlorinated biphenyls (PCBs) (Andrews, 1989;Hoffman et al, 1996;Lind et al, 1999Lind et al, , 2000Lundberg et al, 2006), and polychlorinated dibenzo-p-dioxins (PCDD) (Jämsä et al, 2001;Miettinen et al, 2005).…”

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confidence: 99%

Health of Herring Gulls (Larus argentatus) in Relation to Breeding Location in the Early 1990s. III. Effects on the Bone Tissue

Fox¹,

Lundberg²,

Wejheden³

et al. 2008

Journal of Toxicology and Environmental Health, Part A

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Health effects associated with the Great Lakes environment were assessed in adult herring gulls (Larus argentatus) in the early 1990s, including the size and quality of their bones. Femurs were excised from 140 individuals from 10 colonies distributed throughout the Great Lakes and 2 reference colonies in Lake Winnipeg (freshwater) and the Bay of Fundy (marine). Femurs of gulls from the Great Lakes differed from the freshwater or marine reference for 9 of 12 variables of size, composition, and strength assessed using peripheral quantitative computed tomography (pQCT) and biomechanical testing. Femurs of Great Lakes gulls were significantly smaller in length (−2.9%), periosteal circumference (−2.4%), and crosssectional area (−5.4%) than freshwater reference birds. Femurs of the Great Lakes gulls had a lower significant cortical bone mineral content (−8.1%) and density (−2%) than the marine reference. A significant increase in the amount the bone could bend before it broke (+34%) and the energy required to break it (+44%) and a significant decrease (−16.3%) in stiffness during three-point biomechanical bending test were also detected in Great Lakes versus the freshwater gulls. These differences are indicative of impaired mineralization. When divided into high and low 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity equivalent (TCDD-TEQ) colonies, the amount the bone could bend before it broke and the energy required to break it were significantly higher in the high TEQ colonies, but not high polychlorinated biphenyl (PCB) colonies. Breeding location and dietary choices of Great Lakes herring gulls in the early 1990s resulted in modulations of physiological processes that affected the size, mineralization, and biomechanical properties of bone.

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Developmental Toxicity of PCB 126 (3,3′,4,4′,5-Pentachlorobiphenyl) in Nestling American Kestrels (Falco sparverius)

Cited by 94 publications

References 39 publications

Thyroid Hormone Suppression and Cell-Mediated Immunomodulation in American Kestrels ( Falco sparverius ) Exposed to PCBs

Thyroid Hormone Suppression and Cell-Mediated Immunomodulation in American Kestrels ( Falco sparverius ) Exposed to PCBs

Oral administration of PCBs induces proinflammatory and prometastatic responses

Health of Herring Gulls (Larus argentatus) in Relation to Breeding Location in the Early 1990s. III. Effects on the Bone Tissue

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