Developmental study of tethered spinal cord in murine embryos with anorectal malformations

Tsuda, Tomoki; Shimotake, Takashi; Aoi, Shigeyoshi; Kume, Yoko; Deguchi, Eiichi; Iwai, Naoharu

doi:10.1016/j.jpedsurg.2005.08.009

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…In those patients, a bowel management program including antegrade continence enema procedure was necessary. One possible explanation is because an animal experiment showing that neurologic pathways controlling urinary and fecal continence may be established during early embryogenesis [40]. Another important aspect of spinal cord tethering is that it is not a static condition, with several reports of progressive neurologic deficit in children with tethered cord syndrome [38,41].…”

Section: Discussionmentioning

confidence: 99%

Spinal dysraphism with anorectal malformation: lumbosacral magnetic resonance imaging evaluation of 120 patients

Kim

Chang

Lee

et al. 2010

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

Spinal dysraphism with anorectal malformation: lumbosacral magnetic resonance imaging evaluation of 120 patients

Kim

Chang

Lee

et al. 2010

Journal of Pediatric Surgery

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“…Experiments with murine embryos found that tethered spinal cord could be induced in mouse embryos with ARM by the administration of an overdose of all-trans retinoic acid [2]. Few clinical studies, however, have examined anorectal function in children with ARM and TC, though it has become standard practice to screen patients with anorectal malformations regardless of whether they have TC or not.…”

Section: Introductionmentioning

confidence: 99%

Bowel function after surgery for anorectal malformations in patients with tethered spinal cord

et al. 2007

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Tethered spinal cord (TC) is an anomaly frequently recognized in association with anorectal malformations (ARM). However, the influence of TC on bowel function in children with ARM remains unknown. Furthermore, there are few studies that have assessed anorectal function in children with ARM and TC. The aim of this study was to evaluate anorectal function in ARM patients with TC using clinical assessment and anorectal manometry. Among 258 patients with ARM, this retrospective investigation included 35 patients who underwent spinal magnetic resonance imaging (MRI) after surgery for ARM. The patients were divided into two groups based on the presence or absence of TC, and bowel function was assessed by Kelly's clinical score and anorectal manometry. Tethered cord was found in nine of the 35 patients (26%) with ARM. Of the ARM patients, TC was noted in four of 11 (36%) with high type anomalies, one of 8 (13%) with intermediate type anomalies, two of 14 (14%) with low type anomalies, and two of two patients (100%) with cloacal anomalies. Kelly's clinical score did not significantly differ between the two groups. However, two of the nine patients with TC had poor bowel function (Kelly's score; 2-0 points). On the contrary, patients without TC did not have poor bowel function. Anorectal manometry did not show a significant difference between patients with and without TC. However, the two patients with TC who had poor bowel function by Kelly's score had low anal resting pressure, which was essential for achieving fecal continence. In conclusion, the present study showed that tethered cord was more frequently found in patients with more severe anorectal anomalies. Patients with TC were more likely to have poor bowel function, but this did not reach statistical significance.

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“…A recent immunohistochemical study revealed aberrations in the intramural plexus of the rectal wall on E21, using a rat model of ethylenethiourea-induced ARMs [2]. On the other hand, other authors have investigated various abnormalities in mice with ARMs induced by etretinate or all-trans retinoic acid (ATRA), a vitamin A analogue [3,4,[8][9][10][11][12]. More than 95% of the etretinate-or ATRA-treated embryos had ARMs, and rectoprostatic urethral fistulas and rectocloacal fistulas were the most frequently observed abnormalities in male and female mice, respectively.…”

Section: Discussionmentioning

confidence: 99%

Abnormal development of intrinsic innervation in murine embryos with anorectal malformations

et al. 2011

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Developmental study of tethered spinal cord in murine embryos with anorectal malformations

Cited by 4 publications

References 21 publications

Spinal dysraphism with anorectal malformation: lumbosacral magnetic resonance imaging evaluation of 120 patients

Spinal dysraphism with anorectal malformation: lumbosacral magnetic resonance imaging evaluation of 120 patients

Bowel function after surgery for anorectal malformations in patients with tethered spinal cord

Abnormal development of intrinsic innervation in murine embryos with anorectal malformations

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