Developmental regulation of chick embryo retina neurite extension by extrinsic factors

Lu, Ar Huey; Ruch, Stuart

doi:10.1016/0361-9230(87)90112-2

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…The neural retina of the E7 chick is at a period of extensive neurogenesis, migration, and process formation in vivo , especially of ganglion cells [51-53]. This ability to extend neurites is also manifest in cultures made from this age retinal tissue [54,55]. Chick retinas were dissociated, plated and stained for Palm either 2 days or 7 days after plating.…”

Section: Resultsmentioning

confidence: 99%

Palm is expressed in both developing and adult mouse lens and retina

et al. 2005

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Section: Resultsmentioning

confidence: 99%

Palm is expressed in both developing and adult mouse lens and retina

et al. 2005

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“…Generally, promotion of axonal growth and support for long-distance regeneration are the two requirements in the various experimental strategies for nervous system repair . The existing techniques to stimulate and promote axonal growth include grafting of fetal tissue, the peripheral nerve, Schwann cells, , and olfactory ensheathing cells . Additional options at the molecular level include pharmacological interventions, functional electrical stimulations, and physiotherapies .…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Choline-Like Graphene Oxide Composites for Neurite Sprouting and Outgrowth

Pang²,

Wang³

et al. 2013

ACS Appl. Mater. Interfaces

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Neurodegenerative diseases or acute injuries of the nervous system always lead to neuron loss and neurite damage. Thus, the development of effective methods to repair these damaged neurons is necessary. The construction of biomimetic materials with specific physicochemical properties is a promising solution to induce neurite sprouting and guide the regenerating nerve. Herein, we present a simple method for constructing biomimetic graphene oxide (GO) composites by covalently bonding an acetylcholine-like unit (dimethylaminoethyl methacrylate, DMAEMA) or phosphorylcholine-like unit (2-methacryloyloxyethyl phosphorylcholine, MPC) onto GO surfaces to enhance neurite sprouting and outgrowth. The resulting GO composites were characterized by Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, UV-vis spectrometry, scanning electron microscopy, and contact angle analyses. Primary rat hippocampal neurons were used to investigate nerve cell adhesion, spreading, and proliferation on these biomimetic GO composites. GO-DMAEMA and GO-MPC composites provide the desired biomimetic properties for superior biocompatibility without affecting cell viability. At 2 to 7 days after cell seeding was performed, the number of neurites and average neurite length on GO-DMAEMA and GO-MPC composites were significantly enhanced compared with the control GO. In addition, analysis of growth-associate protein-43 (GAP-43) by Western blot showed that GAP-43 expression was greatly improved in biomimetic GO composite groups compared to GO groups, which might promote neurite sprouting and outgrowth. All the results demonstrate the potential of DMAEMA- and MPC-modified GO composites as biomimetic materials for neural interfacing and provide basic information for future biomedical applications of graphene oxide.

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“…The ability of fibronectin to mediate neu rite extention by PNS neurons, including sen sory and sympathetic neurons from both birds and mammals, has been demonstrated by several laboratories [2, 9, In contrast to these differential responses to fibronectin, both CNS and PNS neurons attach to, and extend neurites upon, sub stratum-bound laminin [2,24,49,69,72,80]. The cumulative results of these, and other, studies, suggest that distinct cell-surface binding properties of PNS and CNS neurons are responsible for differences not only in in teractions with the two molecules, but also for the different responses to fibronectin alone.…”

Section: Central and Peripheral Nervous System Neurons Respond Differmentioning

confidence: 99%