Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?

Tain, You‐Lin; Hsu, Chien‐Ning

doi:10.3390/ijms19092584

Cited by 37 publications

(37 citation statements)

References 78 publications

(137 reference statements)

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“…Reprogramming strategies refers to maneuvers to reverse malprogrammed development to resume normal development [66,67]. These strategies could be nutritional interventions, lifestyle modifications, or pharmacological interventions [68].…”

Section: Reprogramming the Adversities Encountered In Maternal Obesitymentioning

confidence: 99%

“…A mechanistic understanding of how the maternal intrauterine and lactational environment may be mediating offspring common morbidities is critical, because early life may represent an important window for targeted intervention to ameliorate fetal and offspring risk [66]. A previous review suggests that early-life resveratrol supplementation could be considered as a reprogramming strategy against the development of metabolic syndrome-related disorders [67]. Supplementing with certain classes of nutrients in gestation is helpful in reprogramming of maternal adversities.…”

Section: Reprogramming the Adversities Encountered In Maternal Obesitymentioning

confidence: 99%

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Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity

Hsu

Chen

Sheen

et al. 2020

IJERPH

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Maternal obesity during pregnancy is a now a public health burden that may be the culprit underlying the ever-increasing rates of adult obesity worldwide. Understanding the association between maternal obesity and adult offspring’s obesity would inform policy and practice regarding offspring health through available resources and interventions. This review first summarizes the programming effects of maternal obesity and discusses the possible underlying mechanisms. We then summarize the current evidence suggesting that maternal consumption of resveratrol is helpful in maternal obesity and alleviates its consequences. In conclusion, maternal obesity can program offspring development in an adverse way. Maternal resveratrol could be considered as a potential regimen in reprogramming adverse outcomes in the context of maternal obesity.

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Section: Reprogramming the Adversities Encountered In Maternal Obesitymentioning

confidence: 99%

Section: Reprogramming the Adversities Encountered In Maternal Obesitymentioning

confidence: 99%

Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity

Hsu

Chen

Sheen

et al. 2020

IJERPH

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“…For decades, many reports have shown that adverse uteroplacental environments have strong associations with metabolic diseases, cardiovascular diseases, skeletal muscle deformity, and cognitive impairments in adult offspring; this concept is known as the developmental origin of health and disease (DOHaD) [ 72 , 73 ]. The DOHaD concept offers a reprogramming strategy that shifts the therapeutic intervention from adulthood to early-life [ 74 ]. IUGR rats had higher p-AMPK in hypothalamus regardless of feeding compared to appropriate for gestational age (AGA) rats.…”

Section: Reprogrammingmentioning

confidence: 99%

AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications

Kumagai

Itakura

Koya

et al. 2018

IJMS

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Although the global maternal mortality ratio has been consistently reduced over time, in 2015, there were still 303,000 maternal deaths throughout the world, of which 99% occurred in developing countries. Understanding pathophysiology of pregnancy complications contributes to the proper prenatal care for the reduction of prenatal, perinatal and neonatal mortality and morbidity ratio. In this review, we focus on AMP-activated protein kinase (AMPK) as a regulator of pregnancy complications. AMPK is a serine/threonine kinase that is conserved within eukaryotes. It regulates the cellular and whole-body energy homeostasis under stress condition. The functions of AMPK are diverse, and the dysregulation of AMPK is known to correlate with many disorders such as cardiovascular disease, diabetes, inflammatory disease, and cancer. During pregnancy, AMPK is necessary for the proper placental differentiation, nutrient transportation, maternal and fetal energy homeostasis, and protection of the fetal membrane. Activators of AMPK such as 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR), resveratrol, and metformin restores pregnancy complications such as gestational diabetes mellitus (GDM), preeclampsia, intrauterine growth restriction, and preterm birth preclinically. We also discuss on the relationship between catechol-O-methyltransferase (COMT), an enzyme that metabolizes catechol, and AMPK during pregnancy. It is known that metformin cannot activate AMPK in COMT deficient mice, and that 2-methoxyestradiol (2-ME), a metabolite of COMT, recovers the AMPK activity, suggesting that COMT is a regulator of AMPK. These reports suggest the therapeutic use of AMPK activators for various pregnancy complications, however, careful analysis is required for the safe use of AMPK activators since AMPK activation could cause fetal malformation.

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“…An increase in eNOS after treatment with polyphenols has already been reported [23]. RSV also prevents eNOS uncoupling and enhances eNOS expression [11].…”

Section: Effects Of the Treatment With Rsv/qsc On Sirt 1 And Enos Expmentioning

confidence: 75%

Effect of a Resveratrol/Quercetin Mixture on the Reversion of Hypertension Induced by a Short-Term Exposure to High Sucrose Levels Near Weaning and a Long-Term Exposure That Leads to Metabolic Syndrome in Rats

Castrejón-Téllez

Villegas-Romero

Rubio-Ruiz

et al. 2020

IJMS

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Hypertension is an important global public health problem. Excess sucrose during a short period near weaning (short sucrose period, SSP; sucrose during rat postnatal days 12 to 28) increases the risk of developing hypertension during adulthood and sucrose ingestion for 6 months after weaning also results in metabolic syndrome (MS) accompanied by hypertension. The aim of this study was to test if the mechanisms that lead to hypertension induced by SSP and MS are similarly modified by a resveratrol/quercetin mixture (RSV/QSC) that targets epigenetic cues. We studied the reversion of hypertension by an RSV/QSC mixture administered for 1 month (from month 6 to month 7 of age) in these two models, since it is effective against some signs of MS. RSV/QSC might determine Sirtuin 1 (SIRT1) and Sirtuin 3 (SIRT3) expression that modulates the expression of endothelial nitric oxide synthase (eNOS), which synthesizes nitric oxide (NO), and of superoxide dismutases (SOD1 and 2), which are antioxidant enzymes that have an impact on the NO levels. Short- (SSP) and long-term (MS) exposure to sucrose induced hypertension and RSV/QSC reversed it. It increased the insulin sensitivity, which may determine the eNOS expression. eNOS expression was decreased in aortas from SSP and MS rats and RSV/QSC only elevated its levels in aortas from MS rats. SIRT1 was also only increased in the MS aortas. Hypertension was accompanied by a decrease in total non-enzymatic antioxidant defenses in SSP and MS aortas, which improved with the RSV/QSC treatment. SOD1 expression was not modified by the sucrose treatments, but SOD2 expression was decreased in SSP and MS aortas. The RSV/QSC treatment increased SOD1 expression in MS aortas. SIRT3 was not modified by the sucrose or RSV/QSC treatments. In conclusion, SSP and MS lead to hypertension, but MS leads to more possible epigenetically- regulated mechanisms related to high blood pressure that could be targeted by the RSV/QSC mixture. Therefore, treatment has better effects on hypertension produced by MS.

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Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?

Cited by 37 publications

References 78 publications

Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity

Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity

AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications

Effect of a Resveratrol/Quercetin Mixture on the Reversion of Hypertension Induced by a Short-Term Exposure to High Sucrose Levels Near Weaning and a Long-Term Exposure That Leads to Metabolic Syndrome in Rats

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