Developmental programming of aging trajectory

Vaiserman, Alexander; Koliada, Alexander; Lushchak, Oleh

doi:10.1016/j.arr.2018.07.007

Cited by 41 publications

(30 citation statements)

References 273 publications

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“…Recently, a hypothesis was proposed that aging trajectory and longevity potential may be "programmed" early in development (Vaiserman et al, 2018). In particular, it is assumed that intrauterine growth restriction (IUGR) can result in a low birth weight and a high risk for metabolic disorders in adulthood, whereas fetal macrosomia and resulting high birth weight can predict an enhanced risk for cancers in adulthood (Vaiserman, 2018).…”

Section: Tl and Diseasementioning

confidence: 99%

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

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Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common feature of age-related diseases. Therefore, telomere length (TL) has been recognized for a long time as one of the best biomarkers of aging. Recent research findings, however, indicate that TL per se can only allow a rough estimate of aging rate and can hardly be regarded as a clinically important risk marker for age-related pathologies and mortality. Evidence is obtained that other indicators such as certain immune parameters, indices of epigenetic age, etc., could be stronger predictors of the health status and the risk of chronic disease. However, despite these issues and limitations, TL remains to be very informative marker in accessing the biological age when used along with other markers such as indices of homeostatic dysregulation, frailty index, epigenetic clock, etc. This review article is aimed at describing the current state of the art in the field and at discussing recent research findings and divergent viewpoints regarding the usefulness of leukocyte TL for estimating the human biological age.

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Section: Tl and Diseasementioning

confidence: 99%

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

2021

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“…Genetic and lifestyle factors have been traditionally considered as main determinants of aging rate and longevity. However, accumulating data indicate that both individual’s aging trajectory and population mortality rate may substantially depend on developmental conditions ( Tarry-Adkins and Ozanne, 2014 ; Vaiserman et al, 2018 ). The mechanistic pathways underlying such life-long effects are largely unknown, but modulation of epigenetic regulation of gene expression appears to be the most plausible explanation ( Bianco-Miotto et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Developmental Tuning of Epigenetic Clock

Vaiserman

2018

Front. Genet.

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Research in the field of gerontology has traditionally focused on later life stages. There is increasing evidence, however, that both the rate of age-related functional decline and the later-life health status can be programmed during early development. The central role of epigenetic mechanisms (methylation of DNA, histone modifications and regulation by non-coding RNAs) in mediating these long-term effects has been elucidated. Both rate and direction of age-associated change of epigenetic patterns (“epigenetic drift”) were shown to be largely dependent on early-life environmental conditions. Inter-individual divergences in epigenetic profiles may arise following the stochastic errors in maintaining epigenetic marks, but they may also be adaptively mediated by specific environmental cues. Recent cohort studies indicate that ticking rate of epigenetic clock, estimated by a DNA methylation-based methods, may be developmentally adjusted, and that individual’s discrepancies among epigenetic and chronological age would be likely programmed early in development. In this Perspective article, recent findings suggesting the importance of early-life determinants for life-course dynamics of epigenetic drift are summarized and discussed.

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“…It is also still not clear how consistently reproducible are early-life-induced epigenetic modifications and whether they can persist until older ages when T2D usually manifests. There is some evidence that these modifications can persist life-long, thereby determining the risk of developing aging-related diseases like T2D [104, 105]. The evidence confirming the persistent character of these modifications is, however, still scarce.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Malnutrition-Induced Epigenetic Dysregulation as a Risk Factor for Type 2 Diabetes

Vaiserman

Lushchak

2019

International Journal of Genomics

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Type 2 diabetes (T2D) is commonly regarded as a disease originating from lifestyle-related factors and typically occurring after the age of 40. There is, however, consistent experimental and epidemiological data evidencing that the risk for developing T2D may largely depend on conditions early in life. In particular, intrauterine growth restriction (IUGR) induced by poor or unbalanced nutrient intake can impair fetal growth and also cause fetal adipose tissue and pancreatic β-cell dysfunction. On account of these processes, persisting adaptive changes can occur in the glucose-insulin metabolism. These changes can include reduced ability for insulin secretion and insulin resistance, and they may result in an improved capacity to store fat, thereby predisposing to the development of T2D and obesity in adulthood. Accumulating research findings indicate that epigenetic regulation of gene expression plays a critical role in linking prenatal malnutrition to the risk of later-life metabolic disorders including T2D. In animal models of IUGR, changes in both DNA methylation and expression levels of key metabolic genes were repeatedly found which persisted until adulthood. The causal link between epigenetic disturbances during development and the risk for T2D was also confirmed in several human studies. In this review, the conceptual models and empirical data are summarized and discussed regarding the contribution of epigenetic mechanisms in developmental nutritional programming of T2D.

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Developmental programming of aging trajectory

Cited by 41 publications

References 273 publications

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

Developmental Tuning of Epigenetic Clock

Prenatal Malnutrition-Induced Epigenetic Dysregulation as a Risk Factor for Type 2 Diabetes

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