Developmental Tuning of Epigenetic Clock

Vaiserman, Alexander

doi:10.3389/fgene.2018.00584

Cited by 39 publications

(32 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, the different level of DNA methylation in adults versus neonates could be a function of age, analogous to findings in human blood cells, where global DNA methylation increases a function of age until a decrease in late adulthood [46]. This can be a consequence of the epigenetic clock and epigenetic drift [47]. The current findings illustrate the importance of considering both methylation and histone PTM regulation in studies with rapidly developing species such as daphnids.…”

Section: Discussionsupporting

confidence: 58%

Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-azacytidine

Lindeman

Thaulow

Shang

et al. 2019

Environmental Epigenetics

View full text Add to dashboard Cite

The water flea Daphnia magna is a keystone species in freshwater ecosystems and has been widely used as a model organism in environmental ecotoxicology. This aquatic crustacean is sensitive to environmental stressors and displays considerable plasticity in adapting to changing environmental conditions. Part of this plasticity may be due to epigenetic regulation of gene expression, including changes to DNA methylation and histone modifications. Because of the generally hypomethylated genome of this species, we hypothesized that the histone code may have an essential role in the epigenetic control and that histone modifications might be an early marker for stress. This study aims to characterize the epigenetic, transcriptional and phenotypic responses and their causal linkages in directly exposed adult (F0) Daphnia and peritoneal exposed neonates (F1) after a chronic (7-day) exposure to a sublethal concentration (10 mg/l) of 5-azacytidine, a well-studied vertebrate DNA methylation inhibitor. Exposure of the F0 generation significantly reduced the cumulative fecundity, accompanied with differential expression of genes in the one-carbon-cycle metabolic pathway. In the epigenome of the F0 generation, a decrease in global DNA methylation, but no significant changes on H3K4me3 or H3K27me3, were observed. In the F1 offspring generation, changes in gene expression, a significant reduction in global DNA methylation and changes in histone modifications were identified. The results indicate that exposure during adulthood may result in more pronounced effects on early development in the offspring generation, though interpretation of the data should be carefully done since both the exposure regime and developmental period is different in the two generations examined. The obtained results improve our understanding of crustacean epigenetics and the tools developed may promote use of epigenetic markers in hazard assessment of environmental stressors.

show abstract

Section: Discussionsupporting

confidence: 58%

Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-azacytidine

Lindeman

Thaulow

Shang

et al. 2019

Environmental Epigenetics

View full text Add to dashboard Cite

show abstract

“…Interestingly, however, emerging data suggest that the epigenetic aging “clock” of the placenta may be set largely in early pregnancy and remains largely stable across gestation, lending support to our findings of consistent relationships of PAA with neonatal as well as pre-natal anthropometry measures. For example, PAA has been found to be highly heritable (57%) [41] and the rate of epigenetic aging is found to be developmentally adjusted [36,43] and remains stable across the lifespan [44]. Together, these data suggest that PAA may not exhibit substantial changes across gestation.…”

Section: Discussionmentioning

confidence: 99%

“…For example, twin studies reported considerably high heritability (57%) of epigenetic age acceleration in the placenta [41] as well as other tissues [35,36]. In addition, the rate of epigenetic aging has been found to be developmentally adjusted [36,43] and remains stable across the lifespan [44]. In the present study, we investigated sex-specific associations of PAA with fetal growth, neonatal anthropometry measures, and risk of low birth weight in a cohort of pregnant women in the U.S. with high quality longitudinal fetal sonography data.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the associations of placental epigenetic aging with fetal growth

Tekola‐Ayele

Workalemahu

Gorfu

et al. 2019

Aging

View full text Add to dashboard Cite

Identifying factors that influence fetal growth in a sex-specific manner can help unravel mechanisms that explain sex differences in adverse neonatal outcomes and in-utero origins of cardiovascular disease disparities. Premature aging of the placenta, a tissue that supports fetal growth and exhibits sex-specific epigenetic changes, is associated with pregnancy complications. Using DNA methylation-based age estimator, we investigated the sex-specific relationship of placental epigenetic aging with fetal growth across 13-40 weeks gestation, neonatal size, and risk of low birth weight. Placental epigenetic age acceleration (PAA), the difference between DNA methylation age and gestational age, was associated with reduced fetal weight among males but with increased fetal weight among females. PAA was inversely associated with fetal weight, abdominal circumference, and biparietal diameter at 32-40 weeks among males but was positively associated with all growth measures among females across 13-40 weeks. A 1-week increase in PAA was associated with 2-fold (95% CI 1.2, 3.2) increased odds for low birth weight and 1.5-fold (95% CI 1.1, 2.0) increased odds for small-for-gestational age among males. In all, fetal growth was significantly reduced in males but not females exposed to a rapidly aging placenta. Epigenetic aging of the placenta may underlie sex differences in neonatal outcomes.

show abstract

“…DNA methylation age, evaluated by these predictors, reflects the biological age of a person, which has a close association with individuals’ health status and can be changed by multiple risk factors, such as smoking and obesity (Dugué et al, 2018). Therefore, the difference between DNA methylation age and chronological age (i.e., Δage) may be a promising tool in predicting disease risk and longevity potential in early life (Vaiserman, 2018). Here, we review the dynamics of methylation in aging and discuss the roles of age-dependent methylation changes in the prediction of age and age-related outcomes.…”

Section: Introductionmentioning

confidence: 99%

Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes

2019

View full text Add to dashboard Cite

The biological markers of aging used to predict physical health status in older people are of great interest. Telomere shortening, which occurs during the process of cell replication, was initially considered a promising biomarker for the prediction of age and age-related outcomes (e.g., diseases, longevity). However, the high instability in detection and low correlation with age-related outcomes limit the extension of telomere length to the field of prediction. Currently, a growing number of studies have shown that dynamic DNA methylation throughout human lifetime exhibits strong correlation with age and age-related outcomes. Indeed, many researchers have built age prediction models with high accuracy based on age-dependent methylation changes in certain CpG loci. For now, DNA methylation based on epigenetic clocks, namely epigenetic or DNA methylation age, serves as a new standard to track chronological age and predict biological age. Measures of age acceleration (Δage, DNA methylation age – chronological age) have been developed to assess the health status of a person. In addition, there is evidence that an accelerated epigenetic age exists in patients with certain age-related diseases (e.g., Alzheimer’s disease, cardiovascular disease). In this review, we provide an overview of the dynamic signatures of DNA methylation during aging and emphasize its practical utility in the prediction of various age-related outcomes.

show abstract

Developmental Tuning of Epigenetic Clock

Cited by 39 publications

References 69 publications

Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-azacytidine

Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-azacytidine

Sex differences in the associations of placental epigenetic aging with fetal growth

Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes

Contact Info

Product

Resources

About