Developmental Origins of Osteoporotic Fracture

Cooper, Cyrus; Westlake, Sarah; Harvey, Nicholas C.; Dennison, Elaine

doi:10.1007/978-1-4020-8749-3_16

Cited by 24 publications

(23 citation statements)

References 57 publications

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“…Traditional public health policies have aimed at reducing risk factors associated with bone mass losses during adulthood to prevent osteoporotic fractures in later life [3]. An alternative strategy for prevention of osteoporotic fractures is to focus on optimizing peak bone mass (PBM) [4].…”

Section: Introductionmentioning

confidence: 99%

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

et al. 2017

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The influence of birth weight and length on bone mineral density and content in adolescence. The Tromsø Study, Fit Futures.Purpose: The influence of birth weight and length on bone mineral density and content later in life is unclear, especially in adolescence. This study evaluated the impact of birth weight and length on bone mineral density and content among adolescents.Methods: We included 961 participants from the population-based Fit Future study (2010)(2011). Dual-energy X-ray absorptiometry (DXA) was used to measure bone mineral density (BMD) and bone mineral content (BMC) at femoral neck (FN), total hip (TH) and total body (TB). BMD and BMC measures were linked with birth weight and length ascertained from the Medical Birth Registry of Norway. Linear regression models were used to investigate the influence of birth parameters on BMD and BMC. Corresponding analyses using birth length as exposure gave significantly positive associations with BMC at all sites in both sexes. The significant positive association between birth weight 3 and BMC-TB in girls, and birth length and BMC-TB in boys remained after multivariable adjustment.Conclusions: We found a positive association between birth size and BMC in adolescence.However, this association was attenuated after adjustment for weight, height and physical activity during adolescence.

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Section: Introductionmentioning

confidence: 99%

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

et al. 2017

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“…(37) The increasing understanding of the role of genetics in skeletal health and fracture risk also supports the conjecture that factors such as bone mass should track over time. Family and twin studies have shown that peak bone mass and bone turnover are largely regulated by genetic factors (38) and that fracture risk may be programmed as early as intrauterine life, (39) and control of bone phenotypes associated with fragility fractures in the elderly is expressed early in life. (2,40) Thus, although there are no definitive longitudinal studies, there is increasing evidence that bone strength indices (including bone mass) attained during childhood and adolescence as the result of both genetic and environmental factors are related to bone strength and fracture risk in later life.…”

Section: Discussionmentioning

confidence: 99%

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Baxter-Jones

Faulkner

Forwood

et al. 2011

Journal of Bone and Mineral Research

523

385

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Bone area (BA) and bone mineral content (BMC) were measured from childhood to young adulthood at the total body (TB), lumbar spine (LS), total hip (TH), and femoral neck (FN). BA and BMC values were expressed as a percentage of young-adult values to determine if and when values reached a plateau. Data were aligned on biological ages [years from peak height velocity (PHV)] to control for maturity. TB BA increased significantly from À4 to þ4 years from PHV, with TB BMC reaching a plateau, on average, 2 years later at þ6 years from PHV (equates to 18 and 20 years of age in girls and boys, respectively). LS BA increased significantly from À4 years from PHV to þ3 years from PHV, whereas LS BMC increased until þ4 from PHV. FN BA increased between À4 and þ1 years from PHV, with FN BMC reaching a plateau, on average, 1 year later at þ2 years from PHV. In the circumpubertal years (À2 to þ2 years from PHV): 39% of the young-adult BMC was accrued at the TB in both males and females; 43% and 46% was accrued in males and females at the LS and TH, respectively; 33% (males and females) was accrued at the FN. In summary, we provide strong evidence that BA plateaus 1 to 2 years earlier than BMC. Depending on the skeletal site, peak bone mass occurs by the end of the second or early in the third decade of life. The data substantiate the importance of the circumpubertal years for accruing bone mineral. ß

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“…(6) These have been supplemented by mother-offspring cohort studies in which maternal smoking, low maternal fat stores during midgestation, and high maternal physical activity in late pregnancy were correlated with reduced neonatal bone mineral in the offspring. (7) More recently, we showed in this cohort that maternal vitamin D status and umbilical venous calcium concentration were determinants of bone mass and volumetric BMD (estimated from DXA measurements) in the offspring at 9 yr of age.…”

Section: Discussionmentioning

confidence: 99%

“…(5) Evidence is now growing that the risk of osteoporosis might be modified by environmental influences during intrauterine and early postnatal life. (6) Thus, maternal smoking, nutrition, and physical activity seem to be independently associated with the bone mass of the offspring at birth. (7) Traditionally, maternal diet has been considered in terms of intake of specific nutrients, and mother-offspring cohort studies have pointed to a potential role for insufficient maternal intake of calcium (8) and poor vitamin D status.…”

mentioning

confidence: 99%

Maternal Dietary Patterns During Pregnancy and Childhood Bone Mass: A Longitudinal Study

Cole

Gale

Javaid

et al. 2009

Journal of Bone and Mineral Research

101

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Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption may be of greater relevance. We therefore examined the relationship between maternal dietary pattern during pregnancy and bone mass of the offspring at 9 yr of age. We studied 198 pregnant women 17-43 yr of age and their offspring at 9 yr of age. Dietary pattern was assessed using principal component analysis from a validated food frequency questionnaire. The offspring underwent measurements of bone mass using DXA at 9 yr of age. A high prudent diet score was characterized by elevated intakes of fruit, vegetables, and wholemeal bread, rice, and pasta and low intakes of processed foods. Higher prudent diet score in late pregnancy was associated with greater (p < 0.001) whole body and lumbar spine BMC and areal BMD in the offspring, after adjustment for sex, socioeconomic status, height, arm circumference, maternal smoking, and vitamin D status. Associations with prudent diet score in early pregnancy were weaker and nonsignificant. We conclude that dietary patterns consistent with current advice for healthy eating during pregnancy are associated with greater bone size and BMD in the offspring at 9 yr of age.

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Developmental Origins of Osteoporotic Fracture

Cited by 24 publications

References 57 publications

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass

Maternal Dietary Patterns During Pregnancy and Childhood Bone Mass: A Longitudinal Study

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