The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

Christoffersen, Tore; Ahmed, Luai A.; Daltveit, Anne Kjersti; Dennison, Elaine; Evensen, Elin Kristin; Furberg, Anne‐Sofie; Gracia‐Marco, Luis; Grimnes, Guri; Nilsen, Ole-Andreas; Schei, Berit; Tell, Grethe S.; Vlachopoulos, Dimitris; Winther, Anne; Emaus, Nina

doi:10.1007/s11657-017-0348-x

Cited by 11 publications

(6 citation statements)

References 39 publications

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“…The estimated effect was modest, 0.13 (95% CI 0.02 to 0.23) and 0.31 (95% CI 0.20 to 0.41) Z ‐score higher TB BMC in boys and girls, respectively. This is in line with previous studies . This finding supports the importance of intrauterine skeletal development, as shown by others .…”

Section: Discussionsupporting

confidence: 94%

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How Is Adolescent Bone Mass and Density Influenced by Early Life Body Size and Growth? The Tromsø Study: Fit Futures—A Longitudinal Cohort Study From Norway

et al. 2018

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The effect of birth weight and childhood body mass index (BMI) on adolescents’ bone parameters is not established. The aim of this longitudinal, population‐based study was to investigate the association of birth weight, childhood BMI, and growth, with adolescent bone mass and bone density in a sample of 633 adolescents (48% girls) from The Tromsø Study: Fit Futures. This population‐based cohort study was conducted in 2010–2011 and 2012–2013 in Tromsø, Norway. Bone mineral content (BMC) and areal BMD (aBMD) were measured at total hip (TH) and total body (TB) by dual‐energy X‐ray absorptiometry (DXA) and converted to internal Z‐scores. Birth weight and childhood anthropometric measurements were retrospectively obtained from the Medical Birth Registry of Norway and childhood health records. Associations between birth weight, BMI, and growth were evaluated by fitting linear mixed models with repeated measures of BMC and aBMD at ages 15 to 17 and 18 to 20 years as the outcome. In crude analysis, a significant positive association (p < 0.05) with TB BMC was observed per 1 SD score increase in birth weight, observed in both sexes. Higher rate of length growth, conditioned on earlier size, from birth to age 2.5 years, and higher rate of weight gain from ages 6.0 to 16.5 years, conditioned on earlier size and concurrent height growth, revealed stronger associations with bone accrual at ages 15 to 20 years compared with other ages. Compared with being normal weight, overweight/obesity at age 16.5 years was associated with higher aBMD Z‐scores: β coefficient (95% confidence interval [CI]) of 0.78 (0.53, 1.03) and 1.08 (0.85, 1.31) in girls, 0.63 (0.42, 0.85) and 0.74 (0.54, 0.95) in boys at TH and TB, respectively. Similar associations were found for BMC. Being underweight was consistently negatively associated with bone parameters in adolescence. In conclusion, birth weight influences adolescent bone mass but less than later growth and BMI in childhood and adolescence. © 2018 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research

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Section: Discussionsupporting

confidence: 94%

“…This is in line with previous studies. (8,10,46) This finding supports the importance of intrauterine skeletal development, as shown by others. (3,8,10,43) Associations between birth weight and bone strength parameters later in life have been contradictory.…”

Section: Discussionsupporting

confidence: 90%

How Is Adolescent Bone Mass and Density Influenced by Early Life Body Size and Growth? The Tromsø Study: Fit Futures—A Longitudinal Cohort Study From Norway

et al. 2018

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“…Exercise during childhood and adolescence can improve bone mineral content (BMC) and areal bone mineral density (aBMD) with benefits maintained into adulthood (1). Low bone mass during adolescence is associated with increased fracture risk and osteoporosis later in life (2,3). The adolescent years are critical for bone development with up to 43 % of peak bone mass acquired during the 5-year period surrounding peak height velocity (PHV) (4).…”

Section: Introductionmentioning

confidence: 99%

A 9-Month Jumping Intervention to Improve Bone Geometry in Adolescent Male Athletes

Vlachopoulos

Barker

Ubago‐Guisado

et al. 2018

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Dennison et al 28 also found that birth weight and body weight at one-year old determined the bone mass when they were aged about 70 years old. A series of clinical studies related to maternal nutrition and the developmental origins of osteoporosis in United States, 29 Finland, 30 Sweden, 31 Norway, 32 Australia, 33 and the Netherlands 34 also demonstrated the same phenomenon. The information of the studis is shown in Table 1.…”

Section: Evidence From Clinical Studies About Maternal Nutrition and mentioning

confidence: 77%

Maternal nutrition and the developmental origins of osteoporosis in offspring: Potential mechanisms and clinical implications

Zheng

Feng

Zheng

et al. 2018

Exp Biol Med (Maywood)

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Osteoporosis, the most frequent metabolic disorder of bone, is a complex disease with a multifactorial origin that is influenced by genes and environments. However, the pathogenesis of osteoporosis has not been fully elucidated. The theory of "Developmental Origins of Health and Disease" indicates that early life environment exposure determines the risks of cardiometabolic diseases in adulthood. However, investigations into the effects of maternal nutrition and nutrition exposure during early life on the development of osteoporosis are limited. Recently, emerging evidence has strongly suggested that maternal nutrition has long-term influences on bone metabolism in offspring, and epigenetic modifications maybe the underlying mechanisms of this process. This review aimed to address maternal nutrition and its implications for the developmental origins of osteoporosis in offspring. It is novel in providing a theoretical basis for the early prevention of osteoporosis. Impact statement Our review aimed to address maternal nutrition and its implications for the developmental origins of osteoporosis in offspring, that can novelly provide a theoretical basis for the early prevention of osteoporosis.

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The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures

Cited by 11 publications

References 39 publications

How Is Adolescent Bone Mass and Density Influenced by Early Life Body Size and Growth? The Tromsø Study: Fit Futures—A Longitudinal Cohort Study From Norway

How Is Adolescent Bone Mass and Density Influenced by Early Life Body Size and Growth? The Tromsø Study: Fit Futures—A Longitudinal Cohort Study From Norway

A 9-Month Jumping Intervention to Improve Bone Geometry in Adolescent Male Athletes

Maternal nutrition and the developmental origins of osteoporosis in offspring: Potential mechanisms and clinical implications

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