Developmental origins of adult diseases

Mo, Jiaying; Liu, Xuanqi; Huang, Y.; He, Renke; Huang, He‐Feng

doi:10.1515/mr-2022-0027

Cited by 2 publications

(1 citation statement)

References 215 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the malleability of epigenetic modifications to cellular signals, it is not surprising that they also respond to environmental exposures ( Ryznar et al, 2021 ; Mo et al, 2022 ; Tando and Matsui, 2023 ). This is especially true during prenatal and perinatal development, with epigenetic perturbation contributing to long-term adverse health outcomes.…”

Section: Developmental Exposuresmentioning

confidence: 99%

Editorial: In celebration of women in developmental epigenetics

Mann,

Suzuki,

Keller Valsecchi

2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Editorial on the Research Topic In celebration of women in developmental epigeneticsAccording to the United Nations, only 33% of researchers worldwide are women. This number drops dramatically as women move through the academic ranks. Each year, more women professors leave academia (6% assistant; 10% associate; 19% full, 2011-2020, United States), and fewer women are promoted (associate, 7%; full, 12%) compared to men (Spoon et al., 2023). Similarly, in Europe, retention rates in STEM remain low, with only 19% of women at the senior level (=full professor, 2021). These figures are reflected in manuscript submissions, where only 4%-22% of corresponding authors are women (Nature Editorial, 2024;Brück, 2023; Cell Editorial Team, 2022). Further compounding the gender disparity in publishing, women at all levels (graduate students to faculty) are less likely to be credited with authorship than men (Ross et al., 2022). To counteract these trends, this Research Topic is dedicated to publishing manuscripts by women scientists as the first and/or corresponding authors.Women scientists have made pioneering contributions to the field of epigenetics. Mary Lyon's discovery of X-chromosome inactivation provided fundamental insights into dosage compensation mechanisms in mammals. Nobel laureate Barbara McClintock's work, on transposons and epigenetic silencing challenged traditional genetic paradigms and emphasized dynamic gene regulation. Susan Clark's development of bisulfite mutagenesis techniques was the bedrock for the precision mapping of global DNA methylation. Sarah Elgin's pioneering research on heterochromatin structure and function in Drosophila was key to understanding position effect variegation. These women, and many others, stand as role models for women scientists. Here, we highlight the contributions of these articles as a celebration of women in developmental epigenetics. Genomic imprintingGenomic imprinting is an epigenetic process that is dependent on the sex of the parent in which one parental allele is silenced, while the other parental copy is expressed (Barlow and Bartolomei, 2014). Genomic imprinting and its intersection with development have

show abstract

Section: Developmental Exposuresmentioning

confidence: 99%

Editorial: In celebration of women in developmental epigenetics

Mann,

Suzuki,

Keller Valsecchi

2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary

Fletcher,

Stubblefield,

Huff

et al. 2024

Toxicological Sciences

View full text Add to dashboard Cite

Phthalates are used as plasticizers and solvents in consumer products. Virtually 100% of the U.S. population has measurable exposure levels to phthalates, however, the mechanisms by which prenatal exposure to phthalate mixtures affects reproductive health in the offspring remain unclear. Thus, this study tested the hypothesis that prenatal exposure to an environmentally relevant phthalate mixture promotes inflammation in F1 ovarian tissue. Pregnant CD-1 dams were dosed orally with vehicle control (corn oil) or phthalate mixture (20 μg/kg/day, 200 μg/kg/day, 200 mg/kg/day, 500 mg/kg/day). Pregnant dams delivered pups naturally and ovaries and sera from the F1 females were collected at postnatal day (PND) 21, PND 60, 3 months, and 6 months. Sera were used to measure levels of C-reactive protein (CRP). Ovaries and sera were used for cytokine array analysis. RNA was isolated from F1 ovaries and used to quantify expression of selected cytokine genes. Prenatal exposure to the mixture significantly increased the levels of CRP at 200 µg/kg/day on PND 21 compared to controls. The mixture altered 6 immune factors in sera at PND 21 and 33 immune factors in the ovary and sera at 6 months compared to controls. The mixture increased ovarian expression of cytokines at PND 21 and decreased ovarian expression of cytokines at 6 months compared to controls. These data suggest that prenatal exposure to a phthalate mixture interferes with the immune response in F1 female mice long after initial exposure.

show abstract

Developmental origins of adult diseases

Cited by 2 publications

References 215 publications

Editorial: In celebration of women in developmental epigenetics

Editorial: In celebration of women in developmental epigenetics

Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary

Contact Info

Product

Resources

About