Developmental origins of adult disease: Barker's or Dörner's hypothesis?

Koletzko, Berthold

doi:10.1002/ajhb.20139

Cited by 20 publications

(9 citation statements)

References 17 publications

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“…In a visionary article that reviewed a series of clinical and experimental data, Dörner concluded that concentrations of hormones, metabolites, and neurotransmitters during critical early periods of development are capable of preprogramming brain development and functional disturbances up to human adulthood as well as syndromes of reproduction and metabolism. Dörner also proposed an interaction between the genetic material of the individual and environmental influences during early development to determine later function in adult life, which is a concept that has been confirmed by experimental data (1,(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 88%

The Early Nutrition Programming Project (EARNEST): 5 y of successful multidisciplinary collaborative research

Koletzko¹,

Brands²,

Demmelmair³

2011

The American Journal of Clinical Nutrition

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Differences in nutritional experiences during sensitive periods in early life, both before and after birth, can program a person's future development, metabolism, and health. A better scientific understanding of early nutrition programming holds enormous potential for implementing preventive strategies to enhance individuals' longterm health, well-being, and performance. This understanding could reduce costs of health care and social services and may enhance the wealth of societies. The Early Nutrition Programming Project (EARNEST) brought together a multidisciplinary team of international scientists and leaders in key areas of the early nutrition programming field from 40 major research centers across 16 European countries. The project had a total budget of 16.5 million Euros and was funded by the European Communities under the Sixth Framework Program for Research and Technical Development and coordinated by the Children's Hospital at Ludwig-Maximilians-University of Munich. The integrated program of work combined experimental studies in humans, prospective observational studies, and mechanistic animal work, including physiologic studies, cell culture models, and molecular biology techniques. The project lasted from April 2005 to October 2010. After the end of the project, the Early Nutrition Academy (http://www.early-nutrition.org) continues to serve as a platform for the exchange of information, scientific collaboration, and training activities in the area of programming. This article highlights some of the scientific results, achievements, and efforts of EARNEST.Am J Clin Nutr 2011;94(suppl):1749S-53S.

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Section: Introductionmentioning

confidence: 88%

The Early Nutrition Programming Project (EARNEST): 5 y of successful multidisciplinary collaborative research

Koletzko¹,

Brands²,

Demmelmair³

2011

The American Journal of Clinical Nutrition

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“…Breast-feeding positively influences the child's proper development by stimulating the immune system, digestive system and others. The components contained in milk such as growth factors, cytokines, immunoglobulins, lactoferrin, immunocompetent cells have a beneficial effect on the infant's body (Koletzko et al, 2005). The metabolic events at a critical pre-and postnatal time largely affect health in later life (Koletzko, 2005;Koletzko et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Variation of the cholesterol content in breast milk during 10 days collection at early stages of lactation.

Kamelska

Pietrzak-Fiećko²,

Bryl³

2012

Acta Biochim Pol

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More and more research is done concerning nutritional programming. Human milk nutrients which are consumed by infants can influence their health in later life. High level of cholesterol in human milk paradoxically lowers the cholesterol concentration in blood in adults. During the course of human lactation the cholesterol concentration decreases from 31 mg/100cm(3) (colostrum) to 16 mg/100 cm(3) (mature milk). According to Scopesi et al., 2002, Clin Nutr 21: 379-384, cholesterol concentration in mature milk ranged from 6.5 to 18.4 mg/100 cm(3). The aim of the study was to assess the variations in breast milk cholesterol content during 10 day collection at early lactation. 48 samples of human milk were analyzed. Mean age of women was 31 years. Women were collecting samples during 10 days of an early lactation stage (1-3 months after delivery). An Attenuated Total Reflectance Fourier Transformed Infrared (FTIR-ATR) method for easy and rapid determination of cholesterol in human milk was elaborated. Cholesterol content assessed by the FTIR method ranged from 3.36 to 12.98 mg/100 cm(3). Results indicate that milk cholesterol concentration during 10 consecutive days of early lactation is highly variable. Cholesterol content depends on an individual. Therefore it is suggested that not only the period of lactation but also mother's diet, age, season and place of residence are important factors determining cholesterol content.

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“…К основным причинам, оказывающим влияние на раз-витие избыточной массы тела и ожирения, относятся нарушения питания во время внутриутробного периода, недостаточная или избыточная масса тела при рожде-нии, неадекватное поступление пищевых веществ в ран-нем возрасте, особенно на первом году жизни [28][29][30]. Получены данные, свидетельствующие, что повышенное содержание белка в рационе ребенка грудного возраста способствует увеличению темпов роста и набору массы тела [30][31][32].…”

Section: особенности введения прикорма при наличии избыточной массы тunclassified

Complementary Feeding, Peculiarities of Introduction. Clinical Cases

Скворцова¹,

Боровик²,

Бушуева³

et al. 2017

Vopr. sovr. pediatr.

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Developmental origins of adult disease: Barker's or Dörner's hypothesis?

Cited by 20 publications

References 17 publications

The Early Nutrition Programming Project (EARNEST): 5 y of successful multidisciplinary collaborative research

The Early Nutrition Programming Project (EARNEST): 5 y of successful multidisciplinary collaborative research

Variation of the cholesterol content in breast milk during 10 days collection at early stages of lactation.

Complementary Feeding, Peculiarities of Introduction. Clinical Cases

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