Developmental expression of the mouse gene coding for the kr�ppel-like transcription factor KLF5

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

“…Expression of both KLF4 and KLF5 genes are developmentally regulated, with a higher level of expression occurring toward the later stage of fetal development [9,10]. Depending on the tissues, both overlapping and mutually exclusive patterns of expression have been observed for the two genes.…”

“…Depending on the tissues, both overlapping and mutually exclusive patterns of expression have been observed for the two genes. The respective expression of KLF4 and KLF5 in differentiated, post-mitotic villus and proliferative crypt epithelial cells of the adult intestinal tract also occurs during embryonic development [10]. The cellular distribution of KLF4 and KLF5 transcripts in the epidermis of the skin in the late stage embryo mirrors that of intestinal epithelium, wherein KLF4 is more highly expressed in terminally differentiated, quiescent suprabasal layer and KLF5 in the proliferative basal layer of the epidermis [10].…”

Ubiquitin–proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells

“…KLF5 also functions in other physiological and pathological conditions such as embryonic development (Ohnishi et al, 2000), cardiovascular remolding (Shindo et al, 2002), wound healing (Ogata et al, 2000), and cardiac transplantation rejection (Wada et al, 2000(Wada et al, , 2001. It has been reported that expression levels of KLF5 change during embryogenesis (Ohnishi et al, 2000), complete knockout of KLF5 is embryonic lethal in mice (Shindo et al, 2002), and KLF5 was haploinsufficient in inducing vascular conditions (Shindo et al, 2002).…”

“…It has been reported that expression levels of KLF5 change during embryogenesis (Ohnishi et al, 2000), complete knockout of KLF5 is embryonic lethal in mice (Shindo et al, 2002), and KLF5 was haploinsufficient in inducing vascular conditions (Shindo et al, 2002). Recent studies showed that KLF5 is a target of Wnt signaling pathway, which plays an important role in the development of many organisms (Ziemer et al, 2001;Taneyhill and Pennica, 2004).…”

Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor

“…Expression of GKLF is enriched in epithelial cells of the gastrointestinal tract (Ton-That et al, 1997;Behr and Kaestner, 2002) and the skin (Ton-That et al, 1997) and in vascular endothelial cells (Yet et al, 1998;McCormick et al, 2001;Gray et al, 2002). GKLF has been investigated with respect to its role in cellular differentiation, initially within the gastrointestinal tract and in the epidermis where GKLF is critical for late-stage differentiation of skin cells (Ohnishi et al, 2000;Behr and Kaestner, 2002). GKLF has been shown to contain a transcription activation domain as well as a transcription repression domain (Yet et al, 1998;Zhang et al, 1998Zhang et al, , 2000Shie et al, 2000a;Chen et al, 2002).…”