Developmental exposure to chlorpyrifos and diazinon differentially affect passive avoidance performance and nitric oxide synthase-containing neurons in the basolateral complex of the amygdala

Vatanparast, Jafar; Naseh, Maryam; Baniasadi, Mansoureh; Haghdoost-Yazdi, Hashem

doi:10.1016/j.brainres.2012.11.049

Cited by 25 publications

(12 citation statements)

References 56 publications

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“…By adolescence or adulthood, there are also deficits in presynaptic cholinergic activity that, distinct from mid-gestation exposure, are not accompanied by alterations in mAChR density (Qiao and others 2003), and thus involve different synaptic mechanisms from those of the earlier exposure paradigm. Nitric oxide synthase expression is transiently decreased in most cortical regions (Naseh and others 2013) whereas there are late-emergent increases in the hypothalamus (Naseh and Vatanparast 2014) and amygdala (Vatanparast and others 2013). Effects on neurotransmitter systems such as the cholinergic, serotonergic and nitrergic likely have pervasive consequences since they have established trophic roles in developmental events including neurogenesis, differentiation and synaptogenesis and also neuroplasticity (Abreu-Villaça and others 2011; Cossenza and others 2014; Okamoto and Lipton 2015; Wirth and others 2016).…”

Section: Organophosphates (Ops)mentioning

confidence: 99%

“…Increases in norepinephrine and dopamine synaptic activity turnover are unrelated to the magnitude or temporal pattern of cholinesterase inhibition and most evident in brain regions with poor cholinergic innervation (Dam and others 1999). Neuronal nitric oxide synthase expression decreases in most cerebral cortical regions, in the hippocampus (Naseh and others 2013) and in the amygdala (Vatanparast and others 2013) while it increases in hypothalamus (Naseh and Vatanparast 2014) and the pattern and subregions affected is distinct than those after gestational exposure.…”

Section: Organophosphates (Ops)mentioning

confidence: 99%

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Developmental neurotoxicity of succeeding generations of insecticides

Abreu‐Villaça

Levin

2017

Environment International

131

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Insecticides are by design toxic. They must be toxic to effectively kill target species of insects. Unfortunately, they also have off-target toxic effects that can harm other species, including humans. Developmental neurotoxicity is one of the most prominent off-target toxic risks of insecticides. Over the past seven decades several classes of insecticides have been developed, each with their own mechanisms of effect and toxic side effects. This review covers the developmental neurotoxicity of the succeeding generations of insecticides including organochlorines, organophosphates, pyrethroids, carbamates and neonicotinoids. The goal of new insecticide development is to more effectively kill target species with fewer toxic side effects on non-target species. From the experience with the developmental neurotoxicity caused by the generations of insecticides developed in the past advice is offered how to proceed with future insecticide development to decrease neurotoxic risk.

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Section: Organophosphates (Ops)mentioning

confidence: 99%

Section: Organophosphates (Ops)mentioning

confidence: 99%

Developmental neurotoxicity of succeeding generations of insecticides

Abreu‐Villaça

Levin

2017

Environment International

131

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“…Late gestational OP exposure alters the developmental trajectory of a variety of neurotransmitter systems (including serotoninergic, as previously mentioned, and catecholaminergic systems) in a sex-specific manner [65,82–85], supporting the view that chronic low-dose OP exposure impacts a variety of neurotoxic targets different from the cholinergic system. However, interestingly the effects of OPs on non-classical neurotransmission systems, such as the one of the gaseous signaling molecule nitric oxide, are sex-independent [70,86]. …”

Section: Sex-specific Effects Of Op Exposure During Prenatal Brain Dementioning

confidence: 99%

Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course

Comfort

Ré

2017

Curr Envir Health Rpt

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Purpose of Review This review discusses the sex-specific effects of exposure to various organophosphate (OP) pesticides throughout the life course and potential reasons for the differential vulnerabilities observed across sexes. Recent findings Sex is a crucial factor in the response to toxicants yet the sex-specific effects of OP exposure, particularly in juveniles and adults, remain unresolved. This is largely due to study design and inconsistencies in exposure and outcome assessments. Summary Exposure to OPs results in multiple adverse outcomes influenced by many factors including sex. Reported sex-specific effects suggest that males are more susceptible to OPs, which reflects the sex-dependent prevalence of various neurodevelopmental and neurodegenerative disorders such as autism and amyotrophic lateral sclerosis (ALS), in which males are at greater risk. Thus, this review proposes that the biological sex-specific effects elicited by OP exposure may in part underlie the dimorphic susceptibilities observed in neurological disorders. Understanding the immediate and long-term effects of OP exposure across sexes will be critical in advancing our understanding of OP-induced neurotoxicity and disease.

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“…Organophosphorus pesticides (OPs) are a class of insecticides that act by irreversibly inactivating acetylcholinesterase, causing a build-up of acetylcholine in the synapse that leads to uncontrolled activation of sodium ion channel receptors ( Fukuto 1990 ). Acute OP toxicity results from this acetylcholinesterase inhibition; however, biological effects of chronic low-dose exposure may not be mediated by this pathway ( Ray and Richards 2001 ), and these alternate mechanisms have been shown to result in persistent behavioral and/or neurocognitive deficits in animals ( Icenogle et al 2004 ; Levin et al 2002 ; Ricceri et al 2003 ; Timofeeva et al 2008 ; Vatanparast et al 2013 ). Paraoxonase 1 (PON1), an antioxidant, is a key enzyme that deactivates certain OPs ( Costa et al 2003 ).…”

Section: Introductionmentioning

confidence: 99%

Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts

Engel¹,

Bradman

Wolff

et al. 2016

Environ Health Perspect

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Background:Organophosphorus pesticides (OPs) are used in agriculture worldwide. Residential use was common in the United States before 2001.Objectives:We conducted a pooled analysis of four birth cohorts (children’s centers; n = 936) to evaluate associations of prenatal exposure to OPs with child development at 24 months.Methods:Using general linear models, we computed site-specific and pooled estimates of the association of total dialkyl (ΣDAP), diethyl (ΣDEP), and dimethylphosphate (ΣDMP) metabolite concentrations in maternal prenatal urine with mental and psychomotor development indices (MDI/PDI) and evaluated heterogeneity by children’s center, race/ethnicity, and PON1 genotype.Results:There was significant heterogeneity in the center-specific estimates of association for ΣDAP and ΣDMP and the MDI (p = 0.09, and p = 0.05, respectively), as well as heterogeneity in the race/ethnicity-specific estimates for ΣDAP (p = 0.06) and ΣDMP (p = 0.02) and the MDI. Strong MDI associations in the CHAMACOS population per 10-fold increase in ΣDAP (β = –4.17; 95% CI: –7.00, –1.33) and ΣDMP (β = –3.64; 95% CI: –5.97, –1.32) were influential, as were associations among Hispanics (β per 10-fold increase in ΣDAP = –2.91; 95% CI: –4.71, –1.12). We generally found stronger negative associations of ΣDAP and ΣDEP with the 24-month MDI for carriers of the 192Q PON1 allele, particularly among blacks and Hispanics.Conclusions:Data pooling was complicated by center-related differences in subject characteristics, eligibility, and changes in regulations governing residential use of OPs during the study periods. Pooled summary estimates of prenatal exposure to OPs and neurodevelopment should be interpreted with caution because of significant heterogeneity in associations by center, race/ethnicity, and PON1 genotype. Subgroups with unique exposure profiles or susceptibilities may be at higher risk for adverse neurodevelopment following prenatal exposure.Citation:Engel SM, Bradman A, Wolff MS, Rauh VA, Harley KG, Yang JH, Hoepner LA, Barr DB, Yolton K, Vedar MG, Xu Y, Hornung RW, Wetmur JG, Chen J, Holland NT, Perera FP, Whyatt RM, Lanphear BP, Eskenazi B. 2016. Prenatal organophosphorus pesticide exposure and child neurodevelopment at 24 months: an analysis of four birth cohorts. Environ Health Perspect 124:822–830; http://dx.doi.org/10.1289/ehp.1409474

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Developmental exposure to chlorpyrifos and diazinon differentially affect passive avoidance performance and nitric oxide synthase-containing neurons in the basolateral complex of the amygdala

Cited by 25 publications

References 56 publications

Developmental neurotoxicity of succeeding generations of insecticides

Developmental neurotoxicity of succeeding generations of insecticides

Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course

Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts

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