Developmental delays and locomotor activity in the C57BL6/J mouse following neonatal exposure to the fully-brominated PBDE, decabromodiphenyl ether

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

“…They found a delay in the development of the palpebral reflex, and marginal effects on forelimb strength and struggling behavior in males. On PND 70, male rats were hyperactive, but no differences were observed at one year of age (Rice et al 2007). Finally, motor activity alterations (hypo-or hyperactivity depending on the dose levels and the test) were also reported in the killifish, an estuarine minnow, upon exposure during the embryonic stage (Timme-Laragy et al 2006).…”

“…Branchi et al (2005) found a non significant decrease of serum T 4 on PND 22, following developmental exposure to BDE-99 in mice. Postnatal exposure of rats to BDE-209 was reported to decrease the serum levels of T 4 in male animals on PND 22 (Rice et al 2007). Exposure to BDE-47 on GD 6 was found to decrease T 4 levels in dams on PND1, but not on PND 22 (Kuriyama et al 2004b), and to decrease T 4 levels in pups on PND 14, but not on PND1 or PND 22 (Talsness et al 2004).…”

“…Still unclear is whether gender differences exist, as males appear to be more affected in some studies but not in others, and whether the hyperactivity is permanent (or even worsening with age; e.g. Viberg et al 2003a), or only transient (Branchi et al 2002;Rice et al 2007). …”

“…DE-71, given to rats from GD 6 to PND 21 (5, 30 or 100 mg/kg/day) was found to cause no changes in activity in the offspring when tested as adults (age not specified) (MacPhail et al 2003). Rice et al (2007) exposed C57BL6/J mice to BDE-209 postnatally from PND 2-15. They found a delay in the development of the palpebral reflex, and marginal effects on forelimb strength and struggling behavior in males.…”

Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae

“…Several reports have investigated thyroid endocrine disruption in rodents upon BDE-209 exposure (e.g., Rice et al, 2007;Tseng et al, 2008;Van der Ven et al, 2008;Lee et al, 2010). BDE-209 can be debrominated to lower congeners, which are more bioaccumulative and toxic by both biological and non-biological processes (Stapleton et al, 2004;USEPA, 2008).…”