Developmental changes in the intraplacental distribution of placental lactogen and alkaline phosphatase in the rat

Soares, Michael J.

doi:10.1530/jrf.0.0790093

Cited by 59 publications

(19 citation statements)

References 15 publications

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“…The SpragueDawley rat pup does not establish a complete Pglycoprotein blood-brain barrier until appropriately 3 weeks postpartum, making it highly vulnerable to neurotoxic effects . This is unlike the human fetus, where the blood-brain barrier is formed early on during prenatal development (Jette et al, 1995;Van Kalken et al, 1992;Saunders, 1977) The placenta acts as the barrier between the mater nal and fetal circulatory systems and plays an important role in the development and growth of the fetus (Soares, 1987;Knipp et al, 1999). It provides a mechanism for bidirectional exchange of chemicals into and away from the fetus which is critical for normal in utero develop ment (Aleksunes et al, 2008).…”

Section: Importance Of the P-glycoprotein Blood-brain Barriermentioning

confidence: 99%

The Role of P-glycoprotein in Preventing Developmental and Neurotoxicity

Stevens¹,

Breckenridge²,

Wright³

2010

Hayes' Handbook of Pesticide Toxicology

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Section: Importance Of the P-glycoprotein Blood-brain Barriermentioning

confidence: 99%

The Role of P-glycoprotein in Preventing Developmental and Neurotoxicity

Stevens¹,

Breckenridge²,

Wright³

2010

Hayes' Handbook of Pesticide Toxicology

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“…Protocols for the above procedures have been described (Deb et al, 2006;Ain et al, 2006). Alkaline phosphatase activities in deciduomal tissue were measured as previously described (Soares, 1987;Arroyo et al, 2005). The University of Kansas Medical Center Animal Care and Use Committee approved all procedures for handling and experimentation with rodents.…”

Section: Animals and Tissue Preparationmentioning

confidence: 99%

A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor

et al. 2007

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In the mouse, decidual cells differentiate from uterine stromal cells in response to steroid hormones and signals arising from the embryo. Decidual cells are crucially involved in creating the intrauterine environment conducive to embryonic development. Among their many functions is the production of cytokines related to prolactin (PRL), including decidual prolactin-related protein (DPRP). DPRP is a heparin-binding cytokine, which is abundantly expressed in uterine decidua. In this investigation, we have isolated the mouse Dprp gene, characterized its structure and evaluated its biological role. Dprp-null mice were made by replacing exons 2 to 6 of the Dprp gene with an in-frame enhanced green fluorescent protein (EGFP) gene and a neomycin (neo) resistance cassette. Heterozygous intercross breeding of the mutant mice yielded the expected mendelian ratio. Pregnant heterozygote females expressed EGFP within decidual tissue in locations identical to endogenous Dprp mRNA and protein expression. Homozygous Dprpnull mutant male and female mice were viable, exhibited normal postnatal growth rates, were fertile and produced normal litter sizes. A prominent phenotype was observed when pregnant Dprp-null mice were exposed to a physiological stressor. DPRP deficiency interfered with pregnancy-dependent adaptations to hypoxia resulting in pregnancy failure. Termination of pregnancy was associated with aberrations in mesometrial decidual cells, mesometrial vascular integrity, and disruptions in chorioallantoic placenta morphogenesis. The observations suggest that DPRP participates in pregnancy-dependent adaptations to a physiological stressor.

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“…The animals were housed in an environmentally controlled facility, with lights on from 0600 to 2000 h, and allowed free access to food and water. Timed pregnancies and tissue dissections were performed as previously described (Soares 1987, Orwig et al 1997a. Pseudopregnancy was induced by mating with vasectomized males.…”

Section: Animals and Tissue Preparationmentioning

confidence: 99%

Three novel paralogs of the rodent prolactin gene family

Dai

Wang²,

Liu³

et al. 2000

Journal of Endocrinology

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The prolactin (PRL) family consists of a collection of genes expressed in the uterus, placenta and anterior pituitary. These cytokines/hormones participate in the control of maternal-fetal adaptations to pregnancy. In this report, we establish the presence of three new members of the PRL family. Novel expressed sequence tags (ESTs) with homology to PRL were isolated from embryonic and placental cDNA libraries. The cDNAs were sequenced and compared with those of other members of the PRL family. The three new cDNAs were assigned to the PRL family on the basis of sequence similarities and were referred to as PRL-like protein-J (PLP-J), PRL-like protein-K (PLP-K) and PRL-like protein-M (PLP-M). Both rat and mouse PLP-J cDNAs were identified. Rat PLP-J cDNA encodes for a predicted 211 amino acid protein containing a 29 amino acid signal peptide and two putative N-linked glycosylation sites, whereas the mouse PLP-J cDNA encodes for a 212 amino acid protein containing a 29 amino acid signal peptide with a single N-linked glycosylation site. Rat and mouse PLP-J proteins share approximately 79% and 70% nucleotide and amino acid sequence identity, respectively. A full-length rat PLP-K cDNA and a partial tentative mouse PLP-K cDNA were identified. The rat PLP-K cDNA encodes for a predicted 228 amino acid protein containing a 31 amino acid signal peptide and one putative N-linked glycosylation site; the mouse PLP-M cDNA encodes for a predicted 228 amino acid protein containing a 28 amino acid signal peptide and one putative N-linked glycosylation site. Genes for PLP-J, PLP-K and PLP-M are situated at the Prl family locus on mouse chromosome 13. PLP-J was exclusively expressed in decidual tissue from both the mouse and rat. PLP-K was expressed in trophoblast cells of the chorioallantoic placenta and showed an apparent species difference. In the mouse, virtually all trophoblast lineages expressed PLP-K, whereas in the rat, PLP-K expression was restricted to the labyrinthine trophoblast cells. Mouse PLP-M expression was restricted to the junctional zone of the chorioallantoic placenta. In summary, we have identified three new members of the rodent PRL gene family that are expressed in uterine and placental structures. Future experimentation is needed to determine the specific roles of each of these ligands in the biology of pregnancy.

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Developmental changes in the intraplacental distribution of placental lactogen and alkaline phosphatase in the rat

Abstract: Summary. The

Cited by 59 publications

References 15 publications

The Role of P-glycoprotein in Preventing Developmental and Neurotoxicity

The Role of P-glycoprotein in Preventing Developmental and Neurotoxicity

A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor

Three novel paralogs of the rodent prolactin gene family

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