Developmental Changes in Plasma Apolipoproteins B and A-I in Fetal Bovines

Marcos, Edgardo; Mazur, Andrzej; Cardot, Philippe; Coxam, Véronique; Rayssiguier, Yves

doi:10.1159/000243318

Cited by 7 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrary to rat where the intensity of the hepatic editing process changed during development and with age [10], liver of fetal or adult bovines seemed unable to realize these processes [12,30]. These results were in complete agreement with results showing the only presence of the high molecular form of apo B (apo B100) in the plasma of fetal calves [14].…”

Section: Discussionsupporting

confidence: 72%

“…In cultured human [28] and rat [33] hepatocytes or in HepG2 cells [34], these hormones were shown to alter apo B synthesis and secretion by inhibiting apo B mRNA translation [28,34] and by enhancing neosynthesized apo B degradation [33,34]. Such effects would explain, partly, the net decrease in plasma levels of apo B [14] and in LDL rich in apo B [35] found in fetal calves during the last weeks of fetal development.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike adult bovine animals, fetal calves only generate and secrete high molecular weight species of apo B (apo B100) in blood circulation [14] as part of LDL particles [11,15]. Apo B and TG concentrations decreased in the plasma of fetal calves at the end of development [11,14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Developmental Changes in Apolipoprotein B Gene Expression in the Liver of Fetal Calves

et al. 1998

View full text Add to dashboard Cite

Changes in apolipoprotein (apo B) gene expression in the liver were determined in fetal calves from 90 to 260 days of intrauterine life. Results were compared with those obtained from the livers of 1-month-old calves and adult cows. By Western blot analysis using a rabbit antiserum to bovine apo B, apo B100 was detected from 90 days of intrauterine life. Apo B100 was shown to be the only form of apo B detected in the liver of fetal calves whatever the gestational age indicating the lack of editing process during the prenatal period. Hepatic apo B contents were stable during intrauterine life and comparable to those of calves and lower than those of cows. Hepatic contents of apo B mRNA increased with the gestational age similarly to total RNA. Values of apo B mRNA at 260 days of intrauterine life were comparable to those in the liver of 1-month-old calves and adult cows. These results suggested that hepatic synthesis of calf apo B during fetal development is specifically regulated at a posttranscriptional level, either by a decrease in the rate of translation and/or by an increase in the rate of intracellular apo B degradation.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Developmental Changes in Apolipoprotein B Gene Expression in the Liver of Fetal Calves

et al. 1998

View full text Add to dashboard Cite

show abstract

“…In the present study a significant (p≤0.01) increase was observed in the expression of apo A-I in the plasma of calves during the first week of life. Marcos et al (1991) reported, that concentration of apo A-I in the bovine fetal plasma was maintained on a steady level during the whole gestation period and it was considerably lower when compared with plasma apo A-I concentration in calves during the early postnatal period. The authors postulated that the observed phenomenon was primarily related to the increase in the HDL particle size.…”

Section: Discussionmentioning

confidence: 99%

Blood plasma protein and lipid profile changes in calves during the first week of life

Herosimczyk¹,

Lepczyński²,

Ożgo³

et al. 2013

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

The present study was undertaken to determine blood plasma protein and lipid profile changes in healthy Polish Holstein-Fresian calves of Black-and-White variety. Blood was drawn immediately after birth, before first colostrum intake and at the 3 Subsequent four blood samples were collected at 24 hour intervals until the 7 th day of life. Plasma proteins within the isoelectric point ranging from 3.0 to 10.0 were separated using high resolution two-dimensional electrophoresis. Among the 74 protein spots detected and analyzed, 16 were significantly altered during the first week of life. Differentially expressed spots were excised from the gels and subjected to peptide mass fingerprinting using MALDI-TOF MS. In total, 12 spots were successfully identified, which correspond to three proteins, namely: apolipoprotein A-I, apolipoprotein A-IV and fibrinogen gamma-B chain. A gradual increase in plasma triglyceride, total cholesterol, HDL and LDL cholesterol values was shown during the first seven days of calves life. The lowest concentration of these indicators were observed at birth and was followed by a rapid increase during the first week of postnatal life. These changes appear to be related to the transition in energy sources, from a maternal nutrient supply comprising mainly carbohydrates and amino acids to a diet which was rich in fat -colostrum and milk. This was reflected by the intense up-regulation of plasma proteins related with lipid transport and lipoprotein metabolism during the first week of life.

show abstract

“…It has been reported that humans affected by liver diseases frequently show an abnormal apolipoprotein profile (1,16). We recently proposed a quantitative assay for these apolipoproteins in bovines (17,18). Hence, the objective of this study was to examine the relationship between fatty liver and apo B and apo A-I serum concentrations.…”

mentioning

confidence: 99%

Serum apolipoproteins B and A‐I and naturally occurring fatty liver in dairy cows

Marcos¹,

Mazur²,

Cardot³

et al. 1990

Lipids

Self Cite

View full text Add to dashboard Cite

Serum lipids and apolipoprotein (apo) B and A-I concentrations were determined in 164 dairy cows which had undergone liver biopsy in early lactation. The animals were divided into groups according to fatty liver severity on the basis of hepatic triglyceride content. The serum free fatty acid (FFA) concentration was higher in cows that developed fatty livers than in normal cows, and it correlated highly with liver triglycerides. Serum total cholesterol and triglyceride levels did not correlate with hepatic triglycerides. Both apo B and apo A-I levels were significantly decreased in fatty liver cows. In particular, apo B levels showed a strongly negative correlation with liver triglycerides. The present results suggest that hepatic apolipoprotein synthesis is impeded in fatty liver cows.

show abstract

Developmental Changes in Plasma Apolipoproteins B and A-I in Fetal Bovines

Cited by 7 publications

References 18 publications

Developmental Changes in Apolipoprotein B Gene Expression in the Liver of Fetal Calves

Developmental Changes in Apolipoprotein B Gene Expression in the Liver of Fetal Calves

Blood plasma protein and lipid profile changes in calves during the first week of life

Serum apolipoproteins B and A‐I and naturally occurring fatty liver in dairy cows

Contact Info

Product

Resources

About