Developmental Changes in Insulin-like Growth Factor-I (IGF-I) Receptor Levels and Plasma IGF-I Concentrations in Large White and Meishan Pigs

Louveau, Isabelle; Combes, Sylvie; Cochard, Alexis; Bonneau, Michel

doi:10.1006/gcen.1996.0137

Cited by 26 publications

(11 citation statements)

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“…Although the significance of these high levels of plasma GH is not completely understood, GH could contribute to the maintenance of protein accretion in the newborn pig, even in negative energy balance. Plasma IGF-I concentrations increase significantly during the first 3 weeks after birth (Lee et al, 1991 andLouveau et al, 1996). GH receptors increase over the first 10 days of life in liver and IGF-I receptors decrease in the skeletal muscle and liver (Breier et al, 1989;Lee et al, 1993;Louveau et al, 1996;Schnoebelen-Combes et al, 1996).…”

Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

“…Plasma IGF-I concentrations increase significantly during the first 3 weeks after birth (Lee et al, 1991 andLouveau et al, 1996). GH receptors increase over the first 10 days of life in liver and IGF-I receptors decrease in the skeletal muscle and liver (Breier et al, 1989;Lee et al, 1993;Louveau et al, 1996;Schnoebelen-Combes et al, 1996). The somatotropic axis appears to be functional and responsive to GH administration in neonatal pigs although the responsiveness is reduced compared with older pigs (Harrell et al, 1999).…”

Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

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Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Morise

Louveau

Huërou‐Luron

2008

Animal

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With genetic selection, the increase in litter size has led to higher variation in within-litter birth weights in pigs. This has been associated with a reduction in mean birth weights and a rise in the proportion of piglets weighing less than 1 kg at birth. Low birth weight pigs exhibit lower postnatal growth rates and feed efficiency, which may be explained by an inadequate digestion and/or nutrient use as a consequence of prenatal undernutrition. It is now documented that there is a relationship between birth weight and subsequent pattern of growth and development of tissues and organs. During the neonatal period, the rapid somatic growth is accompanied by tremendous anatomical, physiological and chemical composition changes. The present review focuses primarily on the influence of low birth weight on adipose tissue and the gastrointestinal tract growth and development during the suckling period. The importance of the somatotropic axis, insulin, thyroid hormones, glucocorticoids, epidermal growth factor and leptin in the regulation of these developmental processes is also considered.

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Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Morise

Louveau

Huërou‐Luron

2008

Animal

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“…Blood was collected in an heparinised tube and centrifugated to obtain plasma, whereas an other sample was collected in a clean tube, clotted 12 h at 4°C and the serum removed. Plasma concentrations in Insulin-like growth factor I (IGF-I) were measured by double antibody radioimmunoassays, validated [20] after extraction of IGFs binding proteins with ethanol-acid according to Daughaday et al [8]. Thyroid hormones (triiodothyronine T 3 and thyroxine T 4 ) concentrations were determined by radioimmunoassay using commercial kits (ICN, Hyland Avenue, Costa Mesa, CA 92626, USA).…”

Section: Blood Analysesmentioning

confidence: 99%

Effects of high temperature on body temperature and hormonal adjustments in piglets

2002

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-Effects of a high (33°C) or thermoneutral (23 °C) temperature on body temperature and endocrine parameters were studied in weaned piglets. Rectal and skin temperatures were measured in four ad libitum fed animals per temperature during three weeks. After this acclimation period, 11 blood samples were withdrawn on a 24-h period. Over the acclimation period, rectal and skin temperatures were 0.6 and 2.9°C higher, respectively, at 33°C than at 23°C (P < 0.01), this change occurring from the 1st day at 23 or 33°C. A tendency of serum leptin concentrations to be lower after meals at 33°C than at 23°C was also displayed (P = 0.09). Plasmatic concentrations in Insulin-like growth factor I and thyroxine were decreased at 33°C relative to 23°C (P < 0.01 and P < 0.06, respectively), and triiodothyronine concentrations tended to be lower at 33°C than at 23°C (P = 0.1), which could account for the lower heat production and growth observed in pigs exposed to high temperatures.piglet / heat exposure / body temperature / thyroid hormones / IGF-I Résumé -Effets d'une température ambiante élevée sur la température corporelle et les ajustements hormonaux chez le porcelet sevré. Les effets d'une température ambiante élevée (33°C) ou thermoneutre (23°C) sur la température corporelle et le statut hormonal sont étudiés chez le porcelet sevré. Les températures rectale et cutanée sont mesurées sur 4 animaux par tempé-rature, nourris à volonté et acclimatés à la température expérimentale pendant trois semaines. Après cette période, les paramètres sanguins sont mesurés sur 11 échantillons prélevés sur un nycthémère. Au cours de la période d'acclimatation, les températures rectale et cutanée sont rapidement supérieures à 33°C qu'à 23°C, respectivement de 0,6 et 2,9°C (P < 0,01). Les concentrations sériques en leptine tendent à être inférieures à 33°C à l'état nourri (P = 0,09). Les taux d'Insulin-like growth factor I et thyroxine plasmatiques sont plus faibles à 33 qu'à 23°C (respectivement P < 0,01 et P < 0,06), et les concentrations en triiodothyronine tendent à être inférieures à 33°C (P = 0,1), en accord avec la production de chaleur et la croissance plus faible de ces animaux au chaud.porcelet / chaleur / température corporelle / hormones thyroïdiennes / IGF-I Reprod. Nutr. Dev. 42 (2002) 45-53 45

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“…1, P < 0.05). After the meal, concentrations differed between the two groups at 15.00, 15.45 and 16.00 h (P < 0.05). Plasma concentrations of leptin, measured just before the 13.40 h meal, were lower in L than in H gilts ( Fig.…”

Section: Resultsmentioning

confidence: 89%

“…All GH [32] and IGF-I [15] binding assays were carried out in triplicate as previously described. Microsomal membrane proteins (400 µg for adipose tissue, 500 µg for liver and muscle and 800 µg per tube for ovaries) were incubated with the 125 I-ligand (30 000 cpm or 0.3 ng per tube for GH and 60 000 cpm or 0.2 ng per tube for IGF-I) in binding buffer (25 mM Tris-HCl (pH 7.4), 10 mM CaCl 2 , 0.5% BSA, 0.02% NaN 3 for GH; 50 mM Tris-HCl (pH 7.4), 5 mM MgCl 2 , 0.5% BSA, 0.02% NaN 3 for IGF-I) in the absence or presence of an excess of unlabelled bGH or IGF-I.…”

Section: Membrane Preparation and Binding Studiesmentioning

confidence: 99%

GH and IGF-I binding sites in adipose tissue, liver, skeletal muscle and ovaries of feed-restricted gilts

2000

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-The influence of feed restriction on GH and IGF-I binding was examined in the cyclic gilt. IGF-I, IGFBPs, insulin and leptin levels in plasma were also measured. Twenty-four gilts whose oestrous cycle was synchronised were used. From day 3 to day 12, (with day 0 being the first day of oestrus) feed allowance was 240% and 80% of the energy requirements for maintenance for well-fed (H) and restricted gilts (L) respectively. Six gilts in each group were treated with an antagonist of GnRH but the treatment had no effect on any reported measurements. Blood and tissue samples were collected on days 12 and 13 respectively. L gilts lost live weight whereas H gilts gained weight. Plasma IGF-I, insulin and leptin concentrations were lower in L than in H gilts whereas plasma IGFBP levels were not affected by feed restriction. The specific binding of 125 I-bGH to adipose tissue, liver, skeletal muscle and ovary membranes did not differ significantly between H and L gilts. Specific binding of 125 I-IGF-I to hepatic membranes was higher in L than in H gilts whereas it did not differ between the two groups in the other tissue membranes.

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Developmental Changes in Insulin-like Growth Factor-I (IGF-I) Receptor Levels and Plasma IGF-I Concentrations in Large White and Meishan Pigs

Cited by 26 publications

References 0 publications

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Effects of high temperature on body temperature and hormonal adjustments in piglets

GH and IGF-I binding sites in adipose tissue, liver, skeletal muscle and ovaries of feed-restricted gilts

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