Developmental Assessment Of Serum Periostin As An Asthma Biomarker In Children

New and future strategies to improve asthma control in children

“…Childhood Origins of Asthma (COAST) data revealed that although periostin levels are 2-to 3-fold higher in children than in adults, those patients with asthma by 6 years of age had significantly higher periostin levels than children who did not have asthma by that age. 128 A study of 6-to 15-year-olds demonstrated significantly higher periostin levels in asthmatic patients than healthy control subjects, with the periostin level correlating with both methacholine PC 20 and mannitol PD 15 values. 129 Although these studies show a relationship between periostin levels and development of pediatric asthma, additional studies examining periostin levels in relation to IL-13 and lebrikizumab in children are needed.…”

Moving towards precision care for childhood asthma

“…Lebrikizumab, a monoclonal antibody against IL-13, resulted in improved lung function among adults with asthma inadequately controlled by ICS [68] especially those with high pretreatment levels of serum periostin, higher baseline exhaled nitric oxide, IgE levels, and peripheral eosinophil counts. Although periostin levels are two-fold to three-fold higher in children than in adults, children with asthma by 6 years of age [69] and 6-15-year olds [70 & ] had significantly higher periostin levels than children who did not have asthma by that age and with the periostin level correlating with BHR in the older children, suggesting that periostin may be an important biomarker in pediatric asthma. Overall, while these biologic immunomodulators appear to have favorable effects in adults with asthma, additional adolescent and pediatric studies to investigate a benefit in asthma outcomes and the use of therapy-guiding biomarkers are needed.…”