Asthma Management for Children

Federico, Monica J.; Hoch, Heather; Anderson, William C.; Spahn, Joseph D.; Szefler, Stanley J.

doi:10.1016/j.yapd.2016.04.010

Cited by 9 publications

(13 citation statements)

References 125 publications

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“…In this study as well, atopic condi ons like allergic rhini s was found to be present in a significant number of asthma c pa ents. Similar results have been published 16 from other parts of the world as well. However, there are studies repor ng to the contrary where no significant associa on was no ced between asthma and allergic 13 rhini s.…”

Section: Discussionsupporting

confidence: 91%

Profile of Patients Presenting with Asthma in Pediatric OPD of Kathmandu Medical College

Bhatta

2018

Birat J. Health Sci.

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Introduction: Asthma is the most common chronic disorder of childhood accounting for a significant proportion of childhood disability. Although asthma has been known to be a result of complex interplay between genetic and environmental factors, other added factors have been studied.Objective: This study was conducted to assess the patient characteristics and different risk factors in children with asthma.Methodology: The study was a cross-sectional study carried out at Kathmandu Medical College for duration of six months. Patients were labeled as asthma as per the diagnosis guideline of Global Initiative for Asthma (GINA) 2016. After the diagnosis of asthma, patient and their caregivers sat for a face to face interview and a detailed proforma was filled up. Data was then entered in SPSS 20 and descriptive analysis was done to analyze the results.Results: A total of 69 patients labeled with the diagnosis of asthma were enrolled during the study period. The mean age of the enrolled patients was 6.44(±3.36) years. Male outnumbered the females (17:8). The study showed 45(65.2%) of the patients had a physician diagnosed allergic rhinitis while only around 5% had atopic dermatitis. Around 52.2% of the patients had a family history of atopy. Most of the patients (75.4%) enrolled in the study were labeled as mild persistent asthma followed by intermittent asthma in 18.8% and moderate persistent asthma in 5.8%.Conclusion: The study found asthma to be more prevalent in male population while mild persistent asthma was the most common severity present in the population. The most frequent risk factor for asthma found in the current study was physician diagnosed allergic rhinitis. BJHS 2018;3(2)6: 480-483.

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Section: Discussionsupporting

confidence: 91%

Profile of Patients Presenting with Asthma in Pediatric OPD of Kathmandu Medical College

Bhatta

2018

Birat J. Health Sci.

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“…Clinically, asthma severity is associated with lung function and airway responsiveness, but underlying pathogenesis of asthma are not clear exactly (10). Thus, the characterization of cytokines might play an important role in the development of diagnostic markers for and treatment and management of pediatric asthma severity (8). This study further supports the use of cytokines as biomarkers, with particular emphasis on noninvasive sampling and cytokine assessment, to evaluate pediatric asthma severity.…”

Section: Contextsupporting

confidence: 56%

“…Increased periostin levels in the blood of children with asthma stimulate collagen synthesis, fibrillogenesis, and TGF-β activation. POSTN gene expression decreases in pediatric asthma after treatment with corticosteroids (8). Serum periostin level is a more useful biomarker of pediatric asthma than blood eosinophil count and IgE level.…”

Section: Periostinmentioning

confidence: 98%

“…Unlike adults, mild to moderate asthma in most children is characterized by eosinophilic and neutrophilic airway inflammation (7). Based on pathogenesis, the degree of airway obstruction, and responses to medications, pediatric asthma can be divided into intermittent, mild, moderate, and severe stages (8,9).…”

Section: Contextmentioning

confidence: 99%

“…Therefore, a useful systemic biomarker of eosinophilia in the airway lumen and tissue (46). In growing children, periostin is released from the bones, but higher periostin levels have been identified in asthmatic children than in healthy children (1,8). More studies are needed on the use of periostin level as a biomarker in clinical practice.…”

Section: Periostinmentioning

confidence: 99%

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Role of Cytokines and Chemokines in the Outcome of Children With Severe Asthma

Hatami

Ghaffari

et al. 2018

JPR

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Context: Asthma, characterized by airway inflammation, is a common chronic disease of childhood. Cytokines and chemokines could be used in the diagnosis, treatment, and management of asthma severity in children. In this review, we have explained the application of cytokines and chemokines as biomarkers in pediatric asthma. Evidence Acquisition: All related articles were separately searched by two researchers using the following keywords in PubMed, Scopus, and Embase databases: Cytokine biomarkers, chemokines biomarkers, and children asthma. Articles published from 2000 to 2017 were investigated in the research, and 28 articles were included in the final analysis for this review. Results: About cytokines, serum Interleukin 4 (IL-4) level is a marker of the presence of asthma, and IL-13 is a key cytokine involved in the manifestation of asthma symptoms. High IL-13 concentration and number of IL-13+ cells in the bronchial submucosa specimens are characteristic of severe asthma. Serum IL-5 concentration 3.1 times in children with severe asthma. IL-17 is involved in airway obstruction. IFN-γ gene polymorphism (+874A/T) in children elevates susceptibility to asthma. TGFB1 polymorphisms are considered as indicators of asthma severity. IL-26 plays an important role in asthma severity. IP-10 may be a useful inflammatory marker of asthma severity. High periostin level has been identified in pediatric asthma. PDGF level, which is high in asthma patients, plays an important role in bronchial fibrosis. About chemokines, plasma TARC concentration may be a useful biomarker of airway inflammation and asthma severity in children. Studies have supported the association between high serum RANTES levels and severe airway obstruction in children. CXCR4 levels are high in pediatric asthma and are associated with disease severity. Conclusions: A wide range of cytokines and chemokines may play important roles in asthma severity in pediatric patients. Therefore, several studies have recommended the use of multiple molecular biomarkers, such as cytokines, for determining asthma severity in children.

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