Developmental Aspects of T Lymphocytes in Aging

Globerson, Amiela; Eren, Rachel; Abel, Loya; Ben-Menahem, David

doi:10.1007/978-1-4613-0513-2_34

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…However, the identity of the cells in the thymus that imprint MHC-restricted specificity is still a subject of controversy. At least two types of thymic stromal cells have been suggested to be involved in T cell selection: resident thymic epithelial cells [9, For further elucidation of these aspects of Tcell development,we have adopted an organ culture system that enables a comparative analysis of inductive interaction of cells from different lymphohemopoietic sources, and the fetal thymus (FT) stroma, leading to T cell differentiation [17-191. We showed recently that when a mixture of BM cells from young and old donors was seeded into a lymphocytedepleted fetal thymus, age-related competition was expressed, resulting in developmental inferiority of cells from the older donors [19,20].This approach enabled us to detect developmental changes in thymus progenitors at the various sources of lymphohemopoietic cells, from early embryonic stages throughout the life span, including the fetal liver (FL) and BM. The results on competitive reconstitution indicate that this experimental model can serve as a tool in measuring the developmental potential of distinct lymphohemopoietic stem cell populations.…”

Section: Introductionmentioning

confidence: 97%

Syngeneic preference manifested by thymic stroma during development of thymocytes from bone marrow cells

Eren¹,

Abel²,

Globerson³

1989

Eur. J. Immunol.

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The question whether major histocompatibility complex (MHC) recognition is expressed in interactions between thymocyte progenitors and thymic stroma cells was investigated in an organ culture system, in which inductive interactions between thymic stroma cells and thymocyte progenitors of different MHC haplotypes could be measured. Thymocyte-depleted fetal thymuses were reconstituted with mixtures of syngeneic and allogeneic bone marrow cells, which also differed in their Thy-1 allele. The relative repopulating ability of the cells was estimated by determining the percentage of emerging Thy-1.1+ vs. Thy-1.2+ thymocytes. Similar values of Thy-1+ cells of the bone marrow donor type developed when the thymus were reconstituted by bone marrow from donors which were either syngeneic or allogeneic to the thymic explants. However, when a 1:1 mixture of syngeneic and allogeneic cells was applied to the thymus, a syngeneic preference was manifested in development of Thy-1+ cells. When mixtures of bone marrow cells from C57BL/Ka (Thy-1.1) and B10.A MHC-congenic (Thy-1.2) mice were used, this developmental preference was found to map to the I-E region. Thymocytes derived from bone marrow cells allogeneic to the stroma, seeded on their own, manifested an advantage over allogeneic bone marrow cells from a different MHC haplotype, in a secondary reconstitution. This suggested that allogeneic bone marrow progenitor cells can be "educated" by the host thymic stroma to behave, in the competitive reconstitution, like syngeneic cells.

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Section: Introductionmentioning

confidence: 97%

Syngeneic preference manifested by thymic stroma during development of thymocytes from bone marrow cells

Eren¹,

Abel²,

Globerson³

1989

Eur. J. Immunol.

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“…Numerous studies have been conducted on cognitive styles, focusing on field dependence (FD) and field independence (FI) cognitive styles. According to (Globerson et al, 1990), the collective findings of various experts' research consistently indicate differences in learning acquisition between individuals with FD and FI cognitive styles. Researchers such as Febrilia and Junita have examined FD and FI cognitive styles as variables in their studies (Febrilia et al, 2019;Junita, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Advanced Organizer Learning Strategies on the Achievement of Fiqh with Varied Cognitive Styles

Mufidah

2024

Al-Hayat J. Islamic. E.

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This study aimed to ascertain the treatment variable's primary influence and interaction effect on learning achievement in the Fiqh course. This study used a quasi-experimental approach, namely the nonequivalent control group design. The participants of the study were divided into two classes, namely Class A and Class B. A random process is conducted in the selection of the study subject class. In contrast, allocating students within each class is considered a fixed entity (intact group) that cannot be altered. The gathered data underwent statistical inference processing utilizing the two-lane 2x2 variant analysis technique. The findings indicated significant variations in learning outcomes in Fiqh courses between two groups of students instructed using different advanced organizer strategies, namely mind maps and concept maps. Additionally, no significant disparity in student achievement in Fiqh courses was observed between students with field dependence and field independence cognitive styles. Furthermore, no interaction effect was found between the learning strategies of advanced organizer types (mind maps and concept maps) and field dependence and field independence cognitive styles on learning achievement in Fiqh courses. The descriptive statistics analysis indicates that implementing the mind map advance organizer strategy (mean 78.59) exhibits a higher level of effectiveness than the concept map advance organizer strategy (mean 67.61) in enhancing student academic performance. It can be inferred that the advanced organizer technique known as the mind map type is consistently more effective than the concept map type, irrespective of variations in cognitive styles. In essence, using mind maps as an advanced organizer by students renders the consideration of cognitive style unnecessary, as it does not exert a differential impact on enhancing academic performance.

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Age related immunomodulation in murine splenocytes induced by delta-9-tetrahydrocannabinol (THC)

Pross

Nakano

Widen

et al. 1993

Mechanisms of Ageing and Development

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Developmental Aspects of T Lymphocytes in Aging

Cited by 8 publications

References 29 publications

Syngeneic preference manifested by thymic stroma during development of thymocytes from bone marrow cells

Syngeneic preference manifested by thymic stroma during development of thymocytes from bone marrow cells

Effectiveness of Advanced Organizer Learning Strategies on the Achievement of Fiqh with Varied Cognitive Styles

Age related immunomodulation in murine splenocytes induced by delta-9-tetrahydrocannabinol (THC)

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