Age related immunomodulation in murine splenocytes induced by delta-9-tetrahydrocannabinol (THC)

Pross, Susan; Nakano, Yasunobu; Widen, Raymond; McHugh, Shannon; Friedman, Herman

doi:10.1016/0047-6374(93)90136-f

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…From these studies, it emerged that cells of different ages respond differentially, in terms of proliferation and cytokine release, when mitogenic stimuli, like concanavalin A, phytoemagglutinin or anti-CD3 antibody, are co-administered together with THC. In particular, when co-stimulated with concanavalin A (or phytoemagglutinin) and THC, cells do not proliferate, independently of their age [136]. In contrast, THC has been found to up-regulate the proliferative response of splenocytes from adult mice, but not from young or old mice, both in vitro and in vivo [136][137][138].…”

Section: Age-related Changes Of Endocannabinoid System In Pheripheralmentioning

confidence: 99%

“…In particular, when co-stimulated with concanavalin A (or phytoemagglutinin) and THC, cells do not proliferate, independently of their age [136]. In contrast, THC has been found to up-regulate the proliferative response of splenocytes from adult mice, but not from young or old mice, both in vitro and in vivo [136][137][138]. The stimulation was found to reflect an increase in the number of both suppressor/cytotoxic T cells as well as mitogen-stimulated T cells.…”

Section: Age-related Changes Of Endocannabinoid System In Pheripheralmentioning

confidence: 99%

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The Endocannabinoid System in Ageing: A New Target for Drug Development

Paradisi

Oddi

Maccarrone

2006

CDT

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Endocannabinoids are a new class of lipids, which include amides, esters and ethers of long chain polyunsaturated fatty acids. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of Delta(9)-tetrahydrocannabinol, the active principle of Cannabis sativa preparations like hashish and marijuana. AEA is released "on demand" from membrane lipids, and its activity at the receptors is limited by cellular uptake followed by intracellular hydrolysis. Together with AEA and congeners, the proteins which bind, synthesize, transport and hydrolyze AEA form the "endocannabinoid system". Endogenous cannabinoids are present in the central nervous system and in peripheral tissues, suggesting a physiological role as broad spectrum modulators. This review summarizes the main features of the endocannabinoid system, and the latest advances on its involvement in ageing of central and peripheral cells. In addition, the therapeutic potential of recently developed drugs able to modulate the endocannabinoid tone for the treatment of ageing and age-related human pathologies will be reviewed.

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