Relationship of aging and cytokines to the immunomodulation by delta-9-tetrahydrocannabinol on murine lymphoid cells

Differential effects of self-reported lifetime marijuana use on interleukin-1 alpha and tumor necrosis factor in African American adults

“…Given the anti-inflammatory constituents in marijuana, researchers and clinicians have begun exploring novel anti-inflammatory therapies utilizing marijuana as a mitigating vector of chronic inflammation based conditions (Albayram et al, 2011; Cabral & Griffin-Thomas, 2009; Canvin & el-Gabalawy, 1999; Gorelick, 2010; Jackson et al, 2005; Marchetti & Abbracchio, 2005; Raber et al, 1998). Though the literature examining marijuana use and immunity is still in its infancy, findings suggest that marijuana alters a variety of innate and adaptive immune system responses in both animals and humans (Klein, Friedman, & Specter, 1998; Klein et al, 2003; Matsuda et al, 2005; Ribeiro et al, 2012; Snella, Pross, & Friedman, 1995). Specifically, previous research examining marijuana’s influence on immune cells posits that the non-psychoactive component cannabidol modulates innate immune responses, such as lymphocytes, natural killer cells, and macrophage function (Baldwin et al, 1997; Chang, Lee, & Lin, 2001; Klein, 2005; Klein et al, 1998).…”