Developmental abnormalities and differential expression of genes induced in oil and dispersant exposed Menidia beryllina embryos

Adeyemo, Olanike K.; Kroll, Kevin J.; Denslow, Nancy D.

doi:10.1016/j.aquatox.2015.09.012

Cited by 52 publications

(20 citation statements)

References 97 publications

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“…Reductions in heart rate have been noted in response to several chemicals, including PAHs (Incardona et al 2004(Incardona et al , 2014Adeyemo et al 2015), 2,3,7,8-tetrachlorodibenzop-dioxin (TCDD;Henry et al 1997;Antkiewicz et al 2005), synthetic musk (Carlsson and Norrgren 2004), and heavy metals (Chen et al 2015;Yin et al 2017), indicating that heart rate is responsive to chemicals with different modes of action. For some of the aforementioned compounds, the inclusion of heart rate improved sensitivity as alterations in heart rate were seen in fish embryos exposed to concentrations that induced 50% mortality Carlsson and Norrgren 2004;Incardona et al 2004;Adeyemo et al 2015;Chen et al 2015). In the present study, heart rate did not display a dose-response trend, with only embryos at the highest surviving dose (8 mg DCA/L) displaying significant reductions in heart rate when compared with controls.…”

Section: Figurecontrasting

confidence: 41%

“…At 96 h, statistical analysis indicated no significant differences in heart rate between groups (Figure B; ANOVA, p = 0.1); however, heart rate was not evaluated in the 8 mg DCA/L group at 96 h because all embryos had hatched. Reductions in heart rate have been noted in response to several chemicals, including PAHs (Incardona et al , 2014; Adeyemo et al ), 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD; Henry et al ; Antkiewicz et al ), synthetic musk (Carlsson and Norrgren ), and heavy metals (Chen et al ; Yin et al ), indicating that heart rate is responsive to chemicals with different modes of action. For some of the aforementioned compounds, the inclusion of heart rate improved sensitivity as alterations in heart rate were seen in fish embryos exposed to concentrations that induced ≤50% mortality (Henry et al ; Carlsson and Norrgren ; Incardona et al ; Adeyemo et al ; Chen et al ).…”

Section: Resultsmentioning

confidence: 99%

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Development of cardiovascular and neurodevelopmental metrics as sublethal endpoints for the Fish embryo toxicity test

Krzykwa

Olivas

Jeffries

2018

Enviro Toxic and Chemistry

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The fathead minnow fish embryo toxicity (FET) test has been proposed as a more humane alternative to current toxicity testing methods as younger organisms are thought to experience less distress during toxicant exposure. However, the FET test protocol does not include endpoints that allow for the prediction of sublethal adverse outcomes, limiting its utility relative to other test types. Researchers have proposed the development of sublethal endpoints for the FET test to increase its utility. The present study 1) developed methods for previously unmeasured sublethal metrics in fathead minnows (i.e., spontaneous contraction frequency and heart rate) and 2) investigated the responsiveness of several sublethal endpoints related to growth (wet wt, length, and growth-related gene expression), neurodevelopment (spontaneous contraction frequency, eye size, and neurodevelopmental gene expression), and cardiovascular function and development (pericardial area, heart rate, and cardiovascular system-related gene expression) as additional FET test metrics using the model toxicant 3,4-dichloroaniline. Of the growth, neurological, and cardiovascular endpoints measured, length, eye size, and pericardial area were found to be more responsive than the other endpoints evaluated. Future studies linking alterations in these endpoints to longer-term adverse impacts are needed to fully evaluate the predictive power of these metrics in chemical and whole-effluent toxicity testing. Environ Toxicol Chem 2018;37:2530-2541. © 2018 SETAC.

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Section: Figurecontrasting

confidence: 41%

Section: Resultsmentioning

confidence: 99%

Development of cardiovascular and neurodevelopmental metrics as sublethal endpoints for the Fish embryo toxicity test

Krzykwa

Olivas

Jeffries

2018

Enviro Toxic and Chemistry

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“…Changes in gene expression of Gulf killifish sampled from oiled marshes indicated exposure to oil (e.g., up-regulation of cyp1a), toxicity (e.g., gill pathology) and reproductive impairment for more than one year after the landfall of oil, despite very low concentrations of hydrocarbons in water and tissues (Dubansky et al, 2013;Whitehead et al, 2012). These responses to DWH oil were replicated in laboratory studies of adult (Pilcher et al, 2014) and larval killifish (Whitehead et al, 2012), and inland silversides (Menidia beryllina) (Adeyemo et al, 2015). Effects on embryos mirrored the toxicity of DWH WAF to zebrafish embryos (Incardona et al, 2013), and included changes to gene expression indicative of PAH accumulation and potential effects on sex determination, sexual differentiation, and growth regulation.…”

Section: Fish In Coastal Habitatsmentioning

confidence: 74%

Environmental effects of the Deepwater Horizon oil spill: A review

Beyer

Trannum

Bakke

et al. 2016

Marine Pollution Bulletin

554

230

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The Deepwater Horizon oil spill constituted an ecosystem-level injury in the northern Gulf of Mexico. Much oil spread at 1100-1300m depth, contaminating and affecting deepwater habitats. Factors such as oil-biodegradation, ocean currents and response measures (dispersants, burning) reduced coastal oiling. Still, >2100km of shoreline and many coastal habitats were affected. Research demonstrates that oiling caused a wide range of biological effects, although worst-case impact scenarios did not materialize. Biomarkers in individual organisms were more informative about oiling stress than population and community indices. Salt marshes and seabird populations were hard hit, but were also quite resilient to oiling effects. Monitoring demonstrated little contamination of seafood. Certain impacts are still understudied, such as effects on seagrass communities. Concerns of long-term impacts remain for large fish species, deep-sea corals, sea turtles and cetaceans. These species and their habitats should continue to receive attention (monitoring and research) for years to come.

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“…(Menidia) (38), salmon (17), Pacific herring (24,39,40), killifish (Fundulus species) (41), tunas (26), sea bass (42), flounder (42), and mahi-mahi (also known as dorado) (43) (Figure 2). Sublethal developmental defects from PAHs and water-soluble oil exposure were initially observed in Pacific herring following the EVOS (44,45).…”

Section: Late Developmental Effects: Cardiac Functionmentioning

confidence: 99%

Impacts of Petroleum-Derived Pollutants on Fish Development

Cherr

Fairbairn

Whitehead

2017

Annu. Rev. Anim. Biosci.

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The teleost fish embryo is particularly sensitive to petroleum hydrocarbons (polycyclic aromatic hydrocarbons, PAHs) at two distinct stages of development. The first is early during cleavage stages when PAHs alter normal signaling associated with establishment of the dorsal-ventral axis. This disruption involves the Wnt/β-catenin pathway and results in hyperdorsalized embryos that do not survive to hatching. The second, more sensitive period is during heart development, when oil and PAHs cause abnormal development of the heart as well as cardiac edema and arrhythmia. Even at extremely low levels (ng/L), PAHs cause subtle edema and altered contractility and heart rate, which impair swimming performance. Some PAHs are extremely phototoxic, such that exposures to trace concentrations result in severe membrane damage and mortality in sunlight. The developing fish embryo is a sensitive indicator of petroleum constituents in the environment, and healthy populations of fish likely require limited PAH exposure during development.

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Developmental abnormalities and differential expression of genes induced in oil and dispersant exposed Menidia beryllina embryos

Cited by 52 publications

References 97 publications

Development of cardiovascular and neurodevelopmental metrics as sublethal endpoints for the Fish embryo toxicity test

Development of cardiovascular and neurodevelopmental metrics as sublethal endpoints for the Fish embryo toxicity test

Environmental effects of the Deepwater Horizon oil spill: A review

Impacts of Petroleum-Derived Pollutants on Fish Development

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