Impacts of Petroleum-Derived Pollutants on Fish Development

Cherr, Gary N.; Fairbairn, Elise A.; Whitehead, Andrew

doi:10.1146/annurev-animal-022516-022928

Cited by 65 publications

(30 citation statements)

References 112 publications

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“…PAHs can dysregulate ß-catenin, a key component of the Wnt pathway, leading to patterning defects in zebrafish and Pacific herring 52 . Wnt signaling is important for early cardiac development, and cardiac dysfunction is a major outcome of PAH toxicity 14 , 61 , 62 . It is unclear if the cardiac defects in PAH-exposed embryos are partially due to disrupted Wnt signaling; several studies demonstrate that PAHs act through the aryl hydrocarbon receptor (AHR) to cause cardiotoxicity 15 , 61 .…”

Section: Discussionmentioning

confidence: 99%

“…Wnt signaling is important for early cardiac development, and cardiac dysfunction is a major outcome of PAH toxicity 14 , 61 , 62 . It is unclear if the cardiac defects in PAH-exposed embryos are partially due to disrupted Wnt signaling; several studies demonstrate that PAHs act through the aryl hydrocarbon receptor (AHR) to cause cardiotoxicity 15 , 61 . AHR activation may cause cardiotoxicity in zebrafish by downstream disruption of Wnt signaling, suggesting that Wnt could play a central role in developmental stormwater toxicity 62 .…”

Section: Discussionmentioning

confidence: 99%

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Urban stormwater runoff negatively impacts lateral line development in larval zebrafish and salmon embryos

Young

Kochenkov

McIntyre

et al. 2018

Sci Rep

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After a storm, water often runs off of impervious urban surfaces directly into aquatic ecosystems. This stormwater runoff is a cocktail of toxicants that have serious effects on the ecological integrity of aquatic habitats. Zebrafish that develop in stormwater runoff suffer from cardiovascular toxicity and impaired growth, but the effects of stormwater on fish sensory systems are not understood. Our study investigated the effect of stormwater on hair cells of the lateral line in larval zebrafish and coho salmon. Our results showed that although toxicants in stormwater did not kill zebrafish hair cells, these cells did experience damage. Zebrafish developing in stormwater also experienced impaired growth, fewer neuromasts in the lateral line, and fewer hair cells per neuromast. A similar reduction in neuromast number was observed in coho salmon reared in stormwater. Bioretention treatment, intended to filter out harmful constituents of stormwater, rescued the lateral line defects in zebrafish but not in coho salmon, suggesting that not all of the harmful constituents were removed by the filtration media and that salmonids are particularly sensitive to aquatic toxicants. Collectively, these data demonstrate that sub-lethal exposure to stormwater runoff negatively impacts a fish sensory system, which may have consequences for organismal fitness.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Urban stormwater runoff negatively impacts lateral line development in larval zebrafish and salmon embryos

Young

Kochenkov

McIntyre

et al. 2018

Sci Rep

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“…The teleost fish embryo is particularly sensitive to PAHs at two distinct stages of development [33]. The first is early during the cleavage stages when PAHs alter the normal signaling associated with the establishment of the dorsal-ventral axis.…”

Section: Toxicity Of Pahs On the Early Development Of Fishmentioning

confidence: 99%

“…PAHs are considered carcinogenic chemicals and are concerning as they are important organic pollutants in the environment and human society ( Figure 1). Moreover, additional toxicological studies have revealed other types of toxicities from PAHs: developmental toxicity, genotoxicity, immunotoxicity, oxidative stress, and endocrine disruption [32][33][34][35][36]. Because of their ubiquity in the natural environment and various harmful effects on organisms, PAHs are among the most concerning organic pollutants.…”

Section: Introductionmentioning

confidence: 99%

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

Honda

Suzuki

2020

IJERPH

385

126

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Polycyclic aromatic hydrocarbons (PAHs) are organic compounds that are widely distributed in the air, water, and soil. Recently, the amount of PAHs derived from fuels and from incomplete combustion processes is increasing. In the aquatic environment, oil spills directly cause PAH pollution and affect marine organisms. Oil spills correlate very well with the major shipping routes. Furthermore, accidental oil spills can seriously impact the marine environment toxicologically. Here, we describe PAH toxicities and related bioaccumulation properties in aquatic animals, including invertebrates. Recent studies have revealed the toxicity of PAHs, including endocrine disruption and tissue-specific toxicity, although researchers have mainly focused on the carcinogenic toxicity of PAHs. We summarize the toxicity of PAHs regarding these aspects. Additionally, the bioaccumulation properties of PAHs for organisms, including invertebrates, are important factors when considering PAH toxicity. In this review, we describe the bioaccumulation properties of PAHs in aquatic animals. Recently, microplastics have been the most concerning environmental problem in the aquatic ecosystem, and the vector effect of microplastics for lipophilic compounds is an emerging environmental issue. Here, we describe the correlation between PAHs and microplastics. Thus, we concluded that PAHs have a toxicity for aquatic animals, indicating that we should emphasize the prevention of aquatic PAH pollution.

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“…For example, globally ubiquitous industrial pollutants such as dioxin-like chemicals (DLCs) may disrupt cardiovascular and craniofacial development in vertebrate embryos (King-Heiden et al, 2012), and in adults may cause immune system, liver, and skin toxicity, reproductive dysfunction, and cancer (Denison, Soshilov, He, DeGroot, & Zhao, 2011). Similarly, some polycyclic aromatic hydrocarbons (PAHs), which are common toxicants in combustion pollutants and crude oil, can cause developmental defects in embryos (Barron, Carls, Heintz, & Rice, 2004;Cherr, Fairbairn, & Whitehead, 2017), and immune system toxicity, oxidative stress, endocrine disruption, and cancer in adults (Hylland, 2006). Deliberately designed poisons tend to have discrete mechanisms of acute biological effect, with distinct molecular targets, so that adaptive phenotypes may be simple.…”

Section: Chemical Complexity and Dimensionality Of The Adaptive Phementioning

confidence: 99%

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Whitehead

Clark

Reid

et al. 2017

Evolutionary Applications

Self Cite

120

102

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For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the effects of human‐mediated environmental changes, including environmental pollution. Here we review how key features of populations, the characteristics of environmental pollution, and the genetic architecture underlying adaptive traits, may interact to shape the likelihood of evolutionary rescue from pollution. Large populations of Atlantic killifish (Fundulus heteroclitus) persist in some of the most contaminated estuaries of the United States, and killifish studies have provided some of the first insights into the types of genomic changes that enable rapid evolutionary rescue from complexly degraded environments. We describe how selection by industrial pollutants and other stressors has acted on multiple populations of killifish and posit that extreme nucleotide diversity uniquely positions this species for successful evolutionary adaptation. Mechanistic studies have identified some of the genetic underpinnings of adaptation to a well‐studied class of toxic pollutants; however, multiple genetic regions under selection in wild populations seem to reflect more complex responses to diverse native stressors and/or compensatory responses to primary adaptation. The discovery of these pollution‐adapted killifish populations suggests that the evolutionary influence of anthropogenic stressors as selective agents occurs widely. Yet adaptation to chemical pollution in terrestrial and aquatic vertebrate wildlife may rarely be a successful “solution to pollution” because potentially adaptive phenotypes may be complex and incur fitness costs, and therefore be unlikely to evolve quickly enough, especially in species with small population sizes.

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Impacts of Petroleum-Derived Pollutants on Fish Development

Cited by 65 publications

References 112 publications

Urban stormwater runoff negatively impacts lateral line development in larval zebrafish and salmon embryos

Urban stormwater runoff negatively impacts lateral line development in larval zebrafish and salmon embryos

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

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