Development, validation of QuEChERS-based method for simultaneous determination of multiclass pesticide residue in milk, and evaluation of the matrix effect

Validation of a modified QuEChERS method to determine multiclass multipesticide residues in apple, banana and guava using GC–MS and LC–MS/MS and its application in real sample analysis

“…Four different other methods were compared with the present methodregarding the standardization of GC-MS. The present method took 50 min run time in comparison to 70.33 min [16], 60.17 min [24], 60 min [25], 55 min [26]. The less run time ofthepresent method in comparison to others was established.…”

“…The quantification was done by matrix-matched standard to appraise the robustnessof the method.Theprecision of the method was evaluated by two steps (a) intra-day (repeatability) which is the analysis of the sample in five replicates in one day by one analyst and their value is calculated by percentage of relative standard deviation, (b) interday(reproducibility) analysis was done by two analysts with the same sample(five replicates)in two alternative day by following all the same experimental and instrumental conditions.The results of precision reproducibility are also calculated with the %RSD. Precision actually asserted the trueness of the method by expressing the value as relative percentage deviation called % RPD [16] @ LOQ level that can be represented by the following equation: Matrix effect can be evaluated by the following equation: F = S matrix ∕S standard , where, S matrix represents peak area of the fortified extract and S standard states peak area of the pure standard. Positive value of % ME indicates matrix enhancement and negative value will be matrix suppression.…”

An analytical study to determine prohibited anabolic residues in red meat tissue using LC-MS/MS system

“…In the preparation step of the sample, the QuEChERS, which is a common method usually performed in pesticide detection was used for anabolic detection (Stubbings & Bigwood, 2009;Tripathy et al, 2019;Yang et al, 2015). Accordingly, the samples were treated with more acetonitrile and the extracts were cleaned by dispersive solid-phase extraction method instead of conventional solid-phase extractions (Chiesa et al, 2016;Fan et al, 2014;Luo et al, 2016;Schmidt et al, 2008;Lehotay et al, 2007;Yang et al, 2009).…”

“…The analytical method was validated according to EU Decision 2002/657/EC and SANTE/12682/2019 directives. Validation linearity, detection and decision limit, recovery, repeatability, reproducibility, and measurement uncertainty parameters were evaluated (European Union, 2019;Gaugain-Juhel et al, 2009;Moussa et al, 2020;Tripathy et al, 2019).…”

Multivariate optimization of a new LC–MS/MS method for the determination of 156 pesticide residues in milk and dairy products

“…Frequently reported chromatographic methods for the determination of multi‐residue pesticide in milk and dairy products are gas chromatography‐mass spectrometry (GC–MS), 8 gas chromatography‐electron capture detector (GC‐ECD) 9 and gas chromatography‐flame photometric detector (GC‐FPD) 10 . Liquid chromatographic methods coupled with a mass spectrometer offer an efficient and are widely used by virtue of superior sensitivity, robustness and selectivity for the determination of pesticide residues in food samples 11–13 .…”