Development the composition and technology for obtaining a dietary supplement “Cachinol” with the antioxidant activity in the form of granules used in the polycystic ovary syndrome

Abstract

Aim. To develop the composition and technology for obtaining a dietary supplement “Cachinol” with the antioxidant activity in the form of granules used in the polycystic ovary syndrome. Materials and methods. To achieve the goal, physical, physicochemical, pharmacotechnological and statistical research methods, as well as generally accepted research methods of the State Pharmacopoeia of Ukraine (SPhU) 2.0 were used in the work. Results and discussion. The rational dosage form is granules. The green tea leaf extract and myo-inositol were chosen as the active pharmaceutical ingredients of granules. For 3 batches of granules, the following parameters were determined: the fractional composition ranging from 13.2 to 17.9 % for 3-2 mm, from 45.3 to 56.2 % for 2-1 mm, from 20.1 to 26.1 % for 1-0.5 mm, from 8.1-12.4 for 0.5-0.25 mm, from 2.95-4.6 % for < 0.25 mm; the moisture content of granules ranging from 2.80-3.10 %; the bulk density – from 0.49 to 0.52 g/cm3, the tapped density – from 0.54 to 0.58 g/cm3; the flowability was in the range of 8.00-8.25 g/s; the angle of repose – from 30 to 33°; disintegration – from 41 to 45 s. Conclusions. The flowchart for obtaining granules in industrial conditions has been developed. The technological process for obtaining granules consists of 8 technological stages. The studies of the technological parameters of granules have been performed in accordance with the requirements of the SPhU 2.0. It has been found that the granules developed meet the requirements of the SPhU 2.0 and can be recommended for further research.

Evaluation of Anti-Inflammatory, Antioxidant Activities and Molecular Docking Analysis of Rubus idaeus Leaf Extract

“…Oxidative stress is a condition characterized by an excessive presence of reactive oxygen species, such as superoxide, hydroxyl radical, hypochlorite, and singlet oxygen. These reactive oxygen species can lead to cellular damage through oxidative stress [31]. Among the enzymes responsible for generating reactive oxygen species is NADPH oxidase, which stands out as the sole enzyme devoted exclusively to this function [32].…”

“…In many chronic diseases such as diabetes mellitus, hypertension, atherosclerosis, Alzheimer's disease, and cancer [1], inflammation and oxidative stress invariably play pivotal roles. During the inflammatory response, neutrophils and macrophages generate substantial quantities of free radicals to combat and eliminate foreign invaders [2,3]. Furthermore, recent research has revealed that non-phagocytic cells, like interleukin-6 (IL-6), can also produce free radicals by expressing NADPH oxidase [4].…”

Investigation of antioxidant interaction between ascorbic acid and rutin in medicine “Ascorutin”

“…However, due to endogenous or exogenous influences, the antioxidant system is not always able to completely inactivate free radicals, thereby increasing the risk of developing the diseases above. Therefore, natural antioxidants found in food are consumed, and in addition, special foods and medicines are added to the daily diet to support the antioxidant system [7,8].…”

Substantiation of the composition and development of technology of granules based on the Alchemilla subcrenata Bus. herbal extract

“…Аналіз останніх досліджень і публікацій. Розроблення гранул на основі лікарської рослинної сировини висвітлено в роботах багатьох учених [1,2,[5][6][7][8]. За результатами аналізу наукових першоджерел з'ясовано, що асортимент гранул на фармацевтичному ринку України є незначним.…”

“…Ефективність лікарського засобу залежить не тільки від природи і дози лікарської речовини, але і від технологічних стадій його виробництва [5][6][7].…”