Development of Ultraviolet Spectrophotometric Method for Analysis of Lornoxicam in Solid Dosage Forms

Abstract

Purpose: An ultraviolet spectrophotometric system was developed and validated for the quantitative determination of lornoxicam in solid dosage forms. Methods:Lornoxicam was dissolved in 0.01M NaOH and analysed using ultraviolet (UV) spectrophotometry. Various analytical parameters such as linearity, precision, accuracy, limit of detection (LOD)

Thiosemicarbazide functionalized carbon quantum dots as a fluorescent probe for the determination of some oxicams: application to dosage forms and biological fluids

“…Using the Student's t-test and the variance ratio F-test, 65 the results obtained were compared to those of reported methods. 22,34,41 According to the calculated t and F values, 65 there is no considerable difference between the methods in terms of accuracy and precision, respectively as shown in Table 5.…”

“…The accuracy of the proposed method was demonstrated by comparing the results of the proposed method in raw materials and pharmaceuticals to the results of the comparison methods. 22,34,41 Data in Table 3 illustrate no signicant differences between the performance of the two methods concerning the accuracy and precision. This was conrmed by statistical analysis of the data using Student's t-test and variance ratio F-test, respectively.…”

“…It differs from other oxicams in that, it has a short elimination half-life (3 to 5 hours), which can be benecial in terms of tolerability. 40 Variable methods were reported for determination of LRX including spectrophotometry, 33,41 spectrouorimetry, 35 HPLC, [42][43][44] and electrochemical methods. 45,46 The previously reported methods require expensive instrumentation, tedious and timeconsuming procedures.…”

Microanalysis of Selected NSAIDs Using the Spectrophotometric Method

“…The basis for the use of the spectrophotometric method is to determine the wavelength that has been absorbed and to determine the degree of intensity of radiation passing through the tested sample [9]. Spectrophotometric methods are a commonly used method, among others, in the study of biochemical processes (monitoring enzymatic reactions, determination of reaction products, measurement of the reaction rate) [10][11][12][13][14] or for quick monitoring of enzymatic reactions, both for measuring the reaction rate and determining reaction products [15]. Direct analyses are possible only when the wavelength characteristic for the determined component is not disturbed by other components or by background absorption [16,17].…”