Development of Triprolidine-Hydrochloride-Loaded pH-Sensitive Poly(Acrylamide-co-Acrylamidoglycolic Acid) Co-Polymer Microspheres: In Vitro Release Studies

Mallikarjuna, B.; Rao, K. Madhusudhana; Prasad, C. Venkata; Rao, K. Chowdoji; Subha, M. C. S.

doi:10.1163/138577211x587645

Cited by 12 publications

(8 citation statements)

References 29 publications

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“…Therefore, polymer particles loaded with this substance via aerosol‐photopolymerization represent a model system for controlled release experiments. A well‐distribution of caffeine within the polymer particles is expected similar to the work of Mallikarjuna et al deducting molecularly dispersed distribution of the drug in the polymer matrix via free radical polymerization for in situ loading. SEM images of caffeine‐loaded spheres and nanocaps are illustrated in Figure a and b.…”

Section: Resultssupporting

confidence: 77%

Perspectives of Aerosol‐Photopolymerization: Nanostructured Polymeric Particles

Akgün

Hubbuch

Wörner

2014

Macro Materials & Eng

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Nanostructured non‐spherical (named nanocaps) and spherical porous particles (named mosaic nanoparticles) are generated by aerosol‐photopolymerization. Nanocaps exhibit well‐defined shapes independent of their diameter and are formed by employing a softening agent and a volatile non‐solvent in the formulation, combining non‐solvent evaporation and retarded gelation. Mosaic nanoparticles are produced by the addition of a non‐volatile non‐solvent into the monomer formulation, provoking phase separation. Both particle structures are generated in situ in the presence of zinc oxide nanoparticles. Similarly, they are loaded with caffeine for release experiments and feature potential for applications in emerging technologies such as optics, functionalized coatings and nanomedicine.

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Section: Resultssupporting

confidence: 77%

Perspectives of Aerosol‐Photopolymerization: Nanostructured Polymeric Particles

Akgün

Hubbuch

Wörner

2014

Macro Materials & Eng

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“…Recently, our group is actively involved in the development of blend polymeric systems for the control release of various types of drugs [30][31][32][33][34]. Earlier, Yerriswamy et al [35] have prepared blend microspheres for controlled release of ciprofloxin hydrochloride.…”

Section: Introductionmentioning

confidence: 99%

Sodium alginate/poly (ethylene oxide) blend hydrogel membranes for controlled release of valganciclovir hydrochloride

Mallikarjuna

Rao

Siraj

et al. 2012

Designed Monomers and Polymers

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Sodium alginate (SA) and poly (ethylene oxide) PEO blend membranes were prepared by solvent casting method for the controlled release of valganciclovir hydrochloride, an antiHIV drug. The prepared membranes were thin, flexible, smooth, and characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), X-ray diffraction (X-RD), scanning electron microscopy (SEM), and tensile strength measurement. FTIR was used to understand the formation of hydrogen bonding between SA and PEO. The DSC and X-RD studies were performed to understand the crystalline nature of drug after encapsulation into the membranes. SEM was used to study the surface morphology of the membranes. Tensile strength measurements revealed the mechanical strength of the membranes. In vitro release studies indicated a dependence of release rate on the extent of crosslinking, amount of drug loading, and the amount of PEO, but slow release rates was extended up to 12 h. Cumulative release data were fitted onto to an empirical equation to compute diffusional exponent (n), which indicated the nonFickian trend for drug release.

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“…These polymers have been used in diverse applications such as self-regulated drug delivery systems, artificial muscles, chemical valves, specialized separation systems, and immobilization of enzymes and cells [3][4][5][6][7][8]. Similar to artificial pancreas, self-regulated insulin release systems could deliver suitable amount of insulin in due time according to the blood glucose level in diabetic patients [9][10][11]. It is glucose-sensitive polymer that plays a key role in the design of such systems [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Glucose and Thermo Dual-Responsive Micelles of an Amphiphilic Graft Copolymer

Zheng

Yang

et al. 2013

International Journal of Polymeric Materials and Polymeric Biom

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Amphiphilic copolymers P(PBA)-g-P(PEG) containing poly(phenylboronic acid) (PPBA) and poly(ethylene glycol) (PEG) side chains were synthesized by copolymerization of 4-vinylphenylboronic acid (PBA) and poly(ethylene glycol) methyl ether methacrylate. The surface tension results showed that the critical micelle concentration (CMC) of P(PBA)-g-P(PEG) was 0.09 g=L. TEM revealed that these copolymers self-assembled into regular sphere micelles above CMC. The photon correlation spectroscopy suggested that they had unique performance of thermo-induced self-assembly. Above critical micelle temperature, they self-assembled into monodisperse micelles with thermosensitivity. Hydrodynamic diameters of these micelles increased dramatically in the presence of glucose. The glucose-regulated drug release behavior was observed through UV-vis spectroscopy.

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Development of Triprolidine-Hydrochloride-Loaded pH-Sensitive Poly(Acrylamide-co-Acrylamidoglycolic Acid) Co-Polymer Microspheres: In Vitro Release Studies

Cited by 12 publications

References 29 publications

Perspectives of Aerosol‐Photopolymerization: Nanostructured Polymeric Particles

Perspectives of Aerosol‐Photopolymerization: Nanostructured Polymeric Particles

Sodium alginate/poly (ethylene oxide) blend hydrogel membranes for controlled release of valganciclovir hydrochloride

Self-Assembled Glucose and Thermo Dual-Responsive Micelles of an Amphiphilic Graft Copolymer

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