Development of TPGS/F127/F68 mixed polymeric micelles: Enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity

Sun, Congyong; Li, Wenjing; Ma, Ping; Yang, Li; Zhu, Yuan; Adu‐Frimpong, Michael; Deng, Wenwen; Yu, Jiangnan; Xu, Ximing

doi:10.1016/j.fct.2020.111126

Cited by 55 publications

(23 citation statements)

References 76 publications

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“…This effect may account for the fact that TPGS would provide a steric effect on the molecular packing within the dispersion core. A similar effect of TPGS on molecular arrange of micelle systems is also reported elsewhere [41]. While there was no observed transition for AV oil and BSFL oil NEs, an other report considered a completely soluble TPGS in a mixture of water and oil [43].…”

Section: Endothermic Phase Change Behaviorsupporting

confidence: 81%

“…The average particle size of NEs added with TPGS (weight ratios 100 and 50% as compared to HL) were quite smaller than those prepared with only HL. Similarly, other works found that addition of TPGS to the colloidal system could decrease the particle size and increase its stability [36,41]. However, the BSFL oil NEs were found to be slightly smaller in size than the AV oil NEs, which was probably affected by the higher content of saturated fatty acid in BSFL oil.…”

Section: Dls Characterization and Physcial Stability Of Nanoemulsions Encapsulated With Apigmentioning

confidence: 67%

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Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

et al. 2021

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Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed nanoemulsions (NEs) using an anti-oxidative polymeric amphiphile, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), hydrogenated soy lecithin (HL), black soldier fly larvae (BSFL) oil, and avocado (AV) oil through pre-homogenization and ultrasonication method. Addition of TPGS (weight ratios 100 and 50% as compared to HL) into NEs effectively reduced particle size and phase transition region area of NEs with pure HL. Incorporation of Apig into NEs made particle size increase and provided a disorder effect on intraparticle molecular packing. Nevertheless, the encapsulation efficiency of NEs for Apig approached to about 99%. The chemical stability of Apig was significantly improved and its antioxidant ability was elevated by incorporation with BSFL oil and AV oil NEs, especially for NEs with single TPGS. NEs with single TPGS also exhibited the best Apig skin deposition. For future application of topical Apig delivery, NEs-gel was formed by the addition of hyaluronic acid (HA) into NEs. Their rheological characteristics were dominated by the surfactant ratios of HL to TPGS.

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Section: Endothermic Phase Change Behaviorsupporting

confidence: 81%

Section: Dls Characterization and Physcial Stability Of Nanoemulsions Encapsulated With Apigmentioning

confidence: 67%

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

et al. 2021

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“…These micelles are characterized by small sizes ($10-200 nm), biodegradability for easy elimination, ability to encapsulate poorly water-soluble drugs, high drug loading capacity and reproducibility, and low cost. [22][23][24] Nanoparticles enhance formulation parameters and improve the therapeutic potential of hydrophobic drugs. [25][26][27] Pluronic® F127 is a biodegradable and biocompatible polymer that is used successfully to develop nanoscale polymeric micelles.…”

Section: Introductionmentioning

confidence: 99%

The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity

et al. 2021

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“…For example, micelles made of block copolymer with different structures or molecular weights showed better thermodynamic and kinetic stability. 112,113 Ciprofloxacin, a P-gp substrate, was delivered by syntheticmixed micelles made of poloxamer, phosphatidylcholine, and cholesterol. In addition to an outstanding drug-loading capability at 88%, the micelles also significantly increased the drug transport across Caco-2 cells.…”

Section: Polymeric Micellementioning

confidence: 99%

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

Wu¹,

Zhao²,

Xu³

2020

IJN

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Bacterial infections are the main infectious diseases and cause of death worldwide. Antibiotics are used to treat various infections ranging from minor to life-threatening ones. The dominant route to administer antibiotics is through oral delivery and subsequent gastrointestinal tract (GIT) absorption. However, the delivery efficiency is limited by many factors such as low drug solubility and/or permeability, gastrointestinal instability, and low antibacterial activity. Nanotechnology has emerged as a novel and efficient tool for targeting drug delivery, and a number of promising nanotherapeutic strategies have been widely explored to overcome these obstacles. In this review, we explore published studies to provide a comprehensive understanding of the recent progress in the area of orally deliverable nanoantibiotic formulations. The first part of this article discusses the functions and underlying mechanisms by which nanomedicines increase the oral absorption of antibiotics. The second part focuses on the classification of oral nano-antibiotics and summarizes the advantages, disadvantages and applications of nanoformulations including lipid, polymer, nanosuspension, carbon nanotubes and mesoporous silica nanoparticles in oral delivery of antibiotics. Lastly, the challenges and future perspective of oral nano-antibiotics for infection disease therapy are discussed. Overall, nanomedicines designed for oral drug delivery system have demonstrated the potential for the improvement and optimization of currently available antibiotic therapies.

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Development of TPGS/F127/F68 mixed polymeric micelles: Enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity

Cited by 55 publications

References 76 publications

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

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