Development of thermosensitive in situ gel nanoemulsions for ocular delivery of acyclovir

In vitro–in vivo evaluation of tetrahydrozoline‐loaded ocular in situ gels on rabbits for allergic conjunctivitis management

“…Formulations with osmolarity values between 150 and 320 mOsm/L do not produce ocular discomfort. Based on previous findings, ocular solution osmolality lower than 100 mOsm/kg and higher than 640 mOsm/kg may cause ocular irritation (Mahboobian, Mohammadi, & Mansouri, 2020). Normal human eyes had an average tear osmolarity values of approximately 302+/−8 mOsm/L (Potvin, Makari, & Rapuano, 2015).…”

Development of nanoparticle-delivery systems for antiviral agents: A review

“… This can be used as an appropriate delivery system to use topically for the treatment of viral ophthalmic disease. [ 108 ] Microemulsion Obtained from pseudoternary diagrams. Acyclovir A cationic charge-inducing agent, L-alanine benzyl ester, was added to the formulations to prepare positively-charged microemulsions.…”

Nanotechnological strategies for systemic microbial infections treatment: A review

“… Mahboobian et al (2020) developed ten different thermo-sensitive in situ thermo-sensitive nanoemulsions in gel carried with acyclovir (ACV) in order to assess the permeation capacity as well as the eye irritability generated by eye pathway infections in models of ex vivo. The NE2b was chosen as being ideal, it consisted of an aqueous phase composed of purified water, triacetin was used as the oil phase, Poloxamer 407 and Poloxamer188 as surfactants and Transcutol P® acting as co-surfactant and finally LCA was added.…”

“… Úlcer Oral Lin et al, 2012 NE Thiazoline oleic acid (2.75 g), paraben in a 6% (w / v) solution of methylparaben and 3% (w / v) of propylparaben in propylene glycol (0.22 g), butylhydroxyanisole (0.001 g) 0, Solutol HS 15 (1.5 g) as an organic phase plus ultrapure water (5.97 g) that made up the aqueous phase. Malária Oral Silva et al, 2020 NE02 Oligonucleotide CpG Double-chain cationic surfactant (DODAC), class B oligonucleotide - murine TLR9 agonist (TLR9 / CpG - ODN 1826), sterile water H5N1 Intramuscular WANG et al, 2020 Rif NE Rifampicin rifampicin (0.1% w / w), oleic acid (1.0% w / w), polysorbate 80 (0.9% w / w) Mili-Q water Ocular tuberculosis eyepiece Henostroza et al, 2020 NE2b acyclovir Water (w / w), ACV 0.25% w / w, polaxamer 407 15.3% (w / w), polaxamer 188 1.33% (w / w) Transcutol®P (w / w), Triacetin (w / w) Herpes eyepiece Mahboobian et al, 2020 NE (Nanoemulsion); SQVM NE (Nanoemulon carried with siquinavir mesylate); Lf-IDV-NEs (idinavir and lactoferrin nanoemulsion); CUR NE (Curcumin Nanoemulsion); CLN (cefuroxime nanoemulsion); Baicalin NE (baicalin nanoemulsion; HBV (chronic hepatitis B); HIV (human immunodeficiency virus); Neuro AIDS (acquired immunodeficiency syndrome); NE2b (acyclovir nanoemulsion); NE02 (nanoemulsion) containing oligonucleotide CpG); Rif NE (Ripamficin Nanoemulsion). …”