Development of thermo-sensitive poly N-isopropyl acrylamide grafted chitosan derivatives

Tamer, Tamer Mahmoud; Omer, Ahmed M.; Hassan, Mohamed A.; Hassan, Mohamed E.; Sabet, Maysa M.; Eldin, M.S. Mohy

doi:10.7324/japs.2015.510.s1

Cited by 44 publications

(14 citation statements)

References 36 publications

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“…The FT-IR spectra for the RC seed extract and RC-nZVI are shown in Figure C. For the RC seed extract, the peak at 3285 cm –1 is assigned to the characteristic O–H stretching vibrations in H 2 O molecules, as well as the O–H groups of polyphenols in the RC seeds. , The peak at 2919 cm –1 is corresponding to the C–H and CH 2 vibrations of aliphatic hydrocarbons. , The peak at 1735 cm –1 is attributed to the CO stretching vibration of the carbonyl group derived from the RC seeds . The absorption peak at 1534 cm –1 is associated to the aromatic ring stretching vibration in the phenolic compound.…”

Section: Resultsmentioning

confidence: 99%

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Green Synthesis of Nano-Zero-Valent Iron Using Ricinus Communis Seeds Extract: Characterization and Application in the Treatment of Methylene Blue-Polluted Water

et al. 2021

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In this study, the removal of methylene blue dye (MB) from aqueous solution was examined using a novel green adsorbent to overcome the obstacles encountered in chemical methods. Ricinus communis (RC) aqueous seeds extract was herein used as a reducing and capping agent to synthesize a novel nano-zero-valent iron (RC-nZVI) for the adsorption of harmful MB. Structural and morphological characterization of the synthesized RC-nZVI were performed using several techniques, e.g., steady-state absorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and zeta potential. The maximum efficiency of the removal was 96.8% at pH 6 and 25 °C. According to the kinetics study results, the adsorption process obeys the pseudo-first-order model. The experimental equilibrium data were fitted to the Freundlich isotherm model, the maximum adsorption capacity reached was 61.37 mg·g–1, and the equilibrium parameters were determined. The synthesized RC-nZVI possesses good reusability and can be considered as a potential economic and environmentally friendly adsorbent.

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Section: Resultsmentioning

confidence: 99%

“…43,76 The peak at 2919 cm −1 is corresponding to the C−H and CH 2 vibrations of aliphatic hydrocarbons. 77,78 The peak at 1735 cm −1 is attributed to the CO stretching vibration of the carbonyl group derived from the RC seeds. 68 The absorption peak at 1534 cm −1 is associated to the aromatic ring stretching vibration in the phenolic compound.…”

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confidence: 99%

Green Synthesis of Nano-Zero-Valent Iron Using Ricinus Communis Seeds Extract: Characterization and Application in the Treatment of Methylene Blue-Polluted Water

et al. 2021

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“…1a , CS had peaks at 1641–1646 cm −1 and 1585 cm −1 corresponding to C = O stretching and N–H (amide II) bending vibration, respectively [ 22 ]. Additionally, it showed absorption bands at 1066 and 1028 cm −1 corresponding to C-O-H stretching [ 23 , 24 ]. PNIPAM displayed distinctive peaks at 1654, 1542, and 1375 cm −1 corresponding to amide I, amide II, and a methyl group in CH(CH 3 ) 2 , respectively [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Papaverine loaded injectable and thermosensitive hydrogel system for improving survival of rat dorsal skin flaps

Mahbub

Kim

Choi

et al. 2023

J Mater Sci: Mater Med

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Vasospasm during reconstructive microsurgery is a common, uncertain, and devastating phenomena concerning flap survival. Topical vasodilators as antispasmodic agents are widely used to reduce vasospasm and enhance microvascular anastomosis in reconstructive microsurgery. In this study, thermo-responsive hydrogel (CNH) was fabricated by grafting chitosan (CS) and hyaluronic acid (HA) to poly(N-isopropylacrylamide) (PNIPAM). Papaverine, an anti-spasmodic agent, was then loaded to evaluate its effect on rat skin flap survival. Post-operative flap survival area and water content of rat dorsal skin flap were measured at 7 days after intradermal application of control hydrogel (CNHP0.0) and papaverine loaded hydrogel (CNHP0.4). Tissue malondialdehyde (MDA) content and superoxide dismutase (SOD) activity was measured using enzyme linked immunosorbent assay (ELISA) to determine oxidative stress in flaps. Hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) were performed to evaluate flap angiogenesis and inflammatory markers. Results showed that CNHP0.4 hydrogel could reduce tissue edema (35.63 ± 4.01%), improve flap survival area (76.30 ± 5.39%), increase SOD activity and decrease MDA content. Consequently, it also increased mean vessel density, upregulated expression of CD34 and VEGF, decreased macrophage infiltration, and reduced CD68 and CCR7 expression based on IHC staining. Overall, these results indicate that CNHP0.4 hydrogel can enhance angiogenesis with anti-oxidative and anti-inflammatory effects and promote skin flap survival by preventing vascular spasm. Graphical Abstract

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“…Chitosan is an amino-polysaccharide formed by N-deacetylation of chitin, which results in the formation of amine groups (-NH 2 ) from acetamide groups (-NHCOCH 3 ) [118,119]. Due to its unique properties, such as polyelectrolyte properties, biocompatibility, hydrophilicity, adhesion properties, biodegradability, and recyclability, chitosan has gained a great deal of interest in a variety of biomedical, water treatment, cosmetics, and food sectors, as demonstrated in numerous papers [42,120,121].…”

Section: Biosorbents Based On Natural Polymersmentioning

confidence: 99%

Insights into Recent Advances of Biomaterials Based on Microbial Biomass and Natural Polymers for Sustainable Removal of Pharmaceuticals Residues

et al. 2023

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Pharmaceuticals are acknowledged as emerging contaminants in water resources. The concentration of pharmaceutical compounds in the environment has increased due to the rapid development of the pharmaceutical industry, the increasing use of human and veterinary drugs, and the ineffectiveness of conventional technologies to remove pharmaceutical compounds from water. The application of biomaterials derived from renewable resources in emerging pollutant removal techniques constitutes a new research direction in the field. In this context, the article reviews the literature on pharmaceutical removal from water sources using microbial biomass and natural polymers in biosorption or biodegradation processes. Microorganisms, in their active or inactive form, natural polymers and biocomposites based on inorganic materials, as well as microbial biomass immobilized or encapsulated in polymer matrix, were analyzed in this work. The review examines the benefits, limitations, and drawbacks of employing these biomaterials, as well as the prospects for future research and industrial implementation. From these points of view, current trends in the field are clearly reviewed. Finally, this study demonstrated how biocomposites made of natural polymers and microbial biomass suggest a viable adsorbent biomaterial for reducing environmental pollution that is also efficient, inexpensive, and sustainable.

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Development of thermo-sensitive poly N-isopropyl acrylamide grafted chitosan derivatives

Cited by 44 publications

References 36 publications

Green Synthesis of Nano-Zero-Valent Iron Using Ricinus Communis Seeds Extract: Characterization and Application in the Treatment of Methylene Blue-Polluted Water

Green Synthesis of Nano-Zero-Valent Iron Using Ricinus Communis Seeds Extract: Characterization and Application in the Treatment of Methylene Blue-Polluted Water

Papaverine loaded injectable and thermosensitive hydrogel system for improving survival of rat dorsal skin flaps

Insights into Recent Advances of Biomaterials Based on Microbial Biomass and Natural Polymers for Sustainable Removal of Pharmaceuticals Residues

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