Development of thermo/redox-responsive diselenide linked methoxy poly (ethylene glycol)-block-poly(ε-caprolactone-co-p-dioxanone) hydrogel for localized control drug release

This paper aimed to develop two types of support materials with a mesoporous structure of mobile crystalline matter (known in the literature as MCM, namely MCM-41 and MCM-48) and to load them with gallic acid. Soft templating methodology was chosen for the preparation of the mesoporous structures—the cylindrical micelles with certain structural characteristics being formed due to the hydrophilic and hydrophobic intermolecular forces which occur between the molecules of the surfactants (cetyltrimethylammonium bromide—CTAB) when a minimal micellar ionic concentration is reached. These mesoporous supports were loaded with gallic acid using three different types of MCM—gallic acid ratios (1:0.41; 1:0.82 and 1:1.21)—and their characterizations by FTIR, SEM, XRD, BET and drug release were performed. It is worth mentioning that the loading was carried out using a vacuum-assisted methodology: the mesoporous materials are firstly kept under vacuum at ~0.1 barr for 30 min followed by the addition of the polyphenol solutions. The concentration of the solutions was adapted such that the final volume covered the wet mesoporous support and—in this case—upon reaching normal atmospheric pressure, the solution was pushed inside the pores, and thus the polyphenols were mainly loaded inside the pores. Based on the SBET data, it can be seen that the specific surface area decreased considerably with the increasing ratio of gallic acid; the specific surface area decreased 3.07 and 4.25 times for MCM-41 and MCM-48, respectively. The sample with the highest polyphenol content was further evaluated from a biological point of view, alone or in association with amoxicillin administration. As expected, the MCM-41 and MCM-48 were not protective against infections—but, due to the loading of the gallic acid, a potentiated inhibition was recorded for the tested gram-negative bacterial strains. Moreover, it is important to mention that these systems can be efficient solutions for the recovery of the gut microbiota after exposure to antibiotics, for instance.

show abstract

“…Triggers are pH, temperature, presence of enzymes, magnetic fields, light, etc. [ 5 , 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential

et al. 2022

View full text Add to dashboard Cite

show abstract

A novel pH-and temperature sensitive polymer based on MoS2 modified poly (N-Isopropyl Acrylamide)/ allyl acetoacetate for doxorubicin delivery: synthesis, characterization, in-vitro release and cytotoxicity studies

2022

View full text Add to dashboard Cite

Thermoresponsive nanocomposite hydrogels: tunable systems for localized cancer theranostics

Tripathi

Mafibaniasadi

Raichur

2023

Functional Nanocomposite Hydrogels

View full text Add to dashboard Cite

Development of thermo/redox-responsive diselenide linked methoxy poly (ethylene glycol)-block-poly(ε-caprolactone-co-p-dioxanone) hydrogel for localized control drug release

Cited by 7 publications

References 58 publications

Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential

Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential

A novel pH-and temperature sensitive polymer based on MoS2 modified poly (N-Isopropyl Acrylamide)/ allyl acetoacetate for doxorubicin delivery: synthesis, characterization, in-vitro release and cytotoxicity studies

Thermoresponsive nanocomposite hydrogels: tunable systems for localized cancer theranostics

Contact Info

Product

Resources

About