Development of thermal-crosslinkable chitosan/maleic terminated polyethylene glycol hydrogels for full thickness wound healing: In vitro and in vivo evaluation

Jafari, Arman; Hassanajili, Shadi; Azarpira, Negar; Karimi, Mohammad Bagher; Geramizadeh, Bita

doi:10.1016/j.eurpolymj.2019.05.046

Cited by 48 publications

(29 citation statements)

References 82 publications

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“…Skin is the largest organ of the human body. − Its main functions are to protect the body, perspire, and feel cold, heat, and pressure. , At the same time, the skin is the human body’s first line of anti-pathogens, which act as a barrier to prevent excessive moisture evaporating from the body and protect the tissues and organs in the body from external viruses. − Wound healing refers to the process of the skin tissue repairing by itself after being damaged due to mechanical, chemical, biotic, or other factors. , According to the period of wound healing, wounds can be divided into acute wounds and chronic wounds. Acute wounds generally refer to abrasions, surgical incisions, and wounds caused by a knife or gunshot, while chronic wounds mainly refer to wounds or ulcers caused by diabetes, venous failure, long-term oppression, and other factors. − For ordinary wounds, the body can generally repair itself.…”

Section: Introductionmentioning

confidence: 99%

Injectable and Degradable PEG Hydrogel with Antibacterial Performance for Promoting Wound Healing

Liu

Jiang

Guo

et al. 2021

ACS Appl. Bio Mater.

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Injectable and degradable PEG hydrogel was prepared via Michael-type addition between cross-linking monomer 4-arm-PEG-MAL and two cross-linkers of hydrolysis degradable PEG-diester-dithiol and non-degradable PEG-dithiol, and it had a porous structure with the uniform pore size. The biocompatibility assays in vitro indicated that PEG hydrogel had excellent biocompatibility and can be degraded naturally without leading to any negative impact on cells. The results of antibacterial experiments showed that PEG hydrogel can inhibit the growth of bacteria. Furthermore, the Cell Counting Kit-8 (CCK-8) assay, LIVE/DEAD cell staining, and scratch healing experiments proved that PEG hydrogel can promote cell proliferation and migration, which had been further confirmed in in vivo experiments on the rat wound models. All experimental results demonstrated that PEG hydrogel is an injectable antibacterial dressing, which can promote the process of wound healing and has great potential in the field of wound healing.

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Section: Introductionmentioning

confidence: 99%

Injectable and Degradable PEG Hydrogel with Antibacterial Performance for Promoting Wound Healing

Liu

Jiang

Guo

et al. 2021

ACS Appl. Bio Mater.

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“…In green composites, compatibilization is achieved through a melt-grafting process of the natural llers onto the polymer chains during extrusion using multi-functional additives, that is, with multiple reactive groups or sites [37]. Normally, these reactive compatibilizers are low-molecular weight (M W ) polymers or oligomers containing multiple epoxy or maleic anhydride (MAH) groups [38,39]. During the so-called reactive extrusion (REX), some of the oxygen-based groups of the compatibilizer form new ester bonds with the terminal hydroxyl (-OH) or carbonyl (-COOH) groups of the biopolyester while, at the same time, other groups can react with the -OH groups present on the surface of the lignocellulosic ller, thus improving compatibility by the formation of covalent bonds [16,40].…”

Section: Introductionmentioning

confidence: 99%

Improving the Mechanical Ductility and Toughness of Injection-molded Polylactide Pieces by the Dual Incorporation of Liquor Waste Derived Spent Coffee Grounds and Oligomers of Lactic Acid

Terroba-Delicado

Fiori²,

Torres‐Giner

et al. 2021

Preprint

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This work puts the Circular Bioeconomy’s concept into action, originally valorizing residues from the beverage liquor coffee industry into reinforcing fillers for green composites of polylactide (PLA). The as-received spent coffee grains derived from liquor waste were first milled to obtain the so-called spent coffee grounds (SCGs), which were then incorporated at 20 wt.% into PLA by extrusion. With the aim of improving the compatibility between the biopolyester and the lignocellulosic particles, two oligomers of lactic acid (OLAs), namely OLA2 and OLA2mal, being the latter functionalized with maleic anhydride (MAH), were both added during the extrusion process at 10 wt.%. The resultant compounded pellets were finally shaped into pieces by injection molding for characterization. Results showed that, as opposite to most claims published in the literature of PLA composites based on lignocellulosic fillers derived from soluble coffee wastes, the incorporation of liquor waste derived SCGs increased the ductility of the pieces by nearly 280% due to their high coffee oil content. The incorporation of OLA2 and OLA2mal contributed to improve the impact strength of the pieces by approximately 6% and 12.6%, respectively. The higher performance of OLA2mal was ascribed to a reduction of crystallinity in the green composite due to the chemical interaction by the MAH groups. However, the incorporation of SCGs into PLA slighlty reduced the thermal stability and yielded a dark-to-brown color, whereas it also delayed the disintegration rate of the pieces in controlled compost soil. Therefore, the results attained herein open up novel opportunities for the development of green composites of PLA with higher ductility and toughness through the valorization of liquor coffee wastes.

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“…Hydrogel formulated using chitosan and maleic terminated polyethylene glycol (PEG-MA) displayed a porous structure with an excellent swelling ratio and biocompatibility. Hydrogel depicted faster-wound closure, and, therefore, has the potential to heal wounds [ 91 ].…”

Section: Polymers Employed In Hydrogel Fabricationmentioning

confidence: 99%

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

et al. 2022

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Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.

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Development of thermal-crosslinkable chitosan/maleic terminated polyethylene glycol hydrogels for full thickness wound healing: In vitro and in vivo evaluation

Cited by 48 publications

References 82 publications

Injectable and Degradable PEG Hydrogel with Antibacterial Performance for Promoting Wound Healing

Injectable and Degradable PEG Hydrogel with Antibacterial Performance for Promoting Wound Healing

Improving the Mechanical Ductility and Toughness of Injection-molded Polylactide Pieces by the Dual Incorporation of Liquor Waste Derived Spent Coffee Grounds and Oligomers of Lactic Acid

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

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