Injectable and Degradable PEG Hydrogel with Antibacterial Performance for Promoting Wound Healing

Liu, Siju; Jiang, Tao; Guo, Renqi; Li, Chuang; Lu, Cuifen; Yang, Guichun; Nie, Junqi; Wang, Feiyi; Yang, Xiaofan; Chen, Zhenbing

doi:10.1021/acsabm.1c00004

Cited by 50 publications

(36 citation statements)

References 48 publications

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“…The scratch assay was performed according to previous reports [ 38 , 39 ]. 5 × 10 4 cells were seeded on a 24-well plate and incubated until 80% confluency.…”

Section: Methodsmentioning

confidence: 99%

3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration

Wang

Xie

et al. 2022

Bioactive Materials

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“…The scratch assay was performed according to previous reports [ 38 , 39 ]. 5 × 10 4 cells were seeded on a 24-well plate and incubated until 80% confluency.…”

Section: Methodsmentioning

confidence: 99%

3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration

Wang

Xie

et al. 2022

Bioactive Materials

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“…Peg or Ch has some beneficial role in tissue regeneration because they promote various cellular functions, for example, migration, adhesion, and proliferation [15,[57][58][59][60]. Furthermore, Peg, B, and Ch have an antimicrobial activity that reduces chances of infection and improves healing in the wound area [61][62][63]. us, it can be said that if the stability of Peg, B, or Ch maintains perfectly, in comparison with other hybrid composite hydrogels, these three composite hydrogels (X : Ge : Peg : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch : G) can largely perform in terms of possible wound healing.…”

Section: Wound Contraction Rate In Albino Wistar Ratmentioning

confidence: 99%

Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model

Hasan

Uddin

Zabin

et al. 2021

International Journal of Biomaterials

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Thermal burns are a major cause of death and suffering around the globe. They can cause debilitating, life-altering injuries as well as lead to significant psychological and financial consequences. Several research works have been conducted in attempt to find a wound healing therapy that is successful. At present, hydrogels have been widely used in cutting-edge research for this purpose because they have suitable properties. This study aimed to see how therapy with chitosan-polyethylene glycol (Ch-Peg) based hydrogels affected the healing of burn wounds in rats. With the concern of public health, xanthan gum (X), boric acid (B), gelatin (Ge), polyethylene glycol (Peg), chitosan (Ch), glutaraldehyde (G), and HPLC-grade water were prepared using X : Ge : G, X : Ge : Peg : G, X : Ge : Ch : G, X : Ge : Peg : Ch : G, X : Ge : B : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch : G. The produced composite hydrogels were examined for swelling ability, biodegradability, rheological characteristics, and porosity. The 3D structure of the hydrogel was revealed by scanning electron microscopy (SEM). After that, the structural characterization technique named Fourier-transform infrared spectroscopy (FTIR) was used to describe the composites (SEM). Lastly, in a rat skin wound model, the efficacy of the produced hydrogels was studied. Swelling ability, biodegradability, rheological properties, and porosity were all demonstrated in composite hydrogels that contained over 90% water. Hydrogels with good polymeric networks and porosity were observed using SEM. The existence of bound water and free, intra- and intermolecule hydrogen-linked OH and NH in the hydrogels was confirmed using FTIR. In a secondary burned rat model, all hydrogels showed significant wound healing effectiveness when compared to controls. When compared to other composite hydrogels, wounds treated with X : Ge : Peg : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch:G recovered faster after 28 days. In conclusion, this research suggests that X : Ge : Peg : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch : G could be used to treat skin injuries in the clinic.

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“…Physical cross-linking Ionic interaction [47,69,83,84,85,134] Hydrogen bonding [42,48,86] Self-assembly [97,152,170] Chemical cross-linking Schiff base reaction [41,70,88,115,148] Michael addition reaction [42,89,90] Free radical polymerization [41,43,69,91,64,173] Click chemistry [95,96,97] Enzyme cross-linking [54,99,100] Therefore, the design of green and non-toxic cross-linking agents and initiators is the focus of future research.…”

Section: Cross-linkingmentioning

confidence: 99%

“…It is characterized by high efficiency, high selectivity, without a large number of by-products, adding catalysts and coupling agents. Liu et al [89] reported an injectable PEG hydrogel based on Michael addition reaction between 4-arm-PEG-MAL and two cross-linkers of PEG-diesterdithiol and PEG-dithiol. PEG hydrogel could promote the process of wound healing and show great potential in the application for wound healing.…”

Section: Chemical Cross-linkingmentioning

confidence: 99%

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Progress in Hydrogels for Skin Wound Repair

Zhang

Wang

et al. 2022

Macromolecular Bioscience

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As the first defensive line between the human body and the outside world, the skin is vulnerable to damage from the external environment. Skin wounds can be divided into acute wounds (mechanical injuries, chemical injuries, and surgical wounds, etc.) and chronic wounds (burns, infections, diabetes, etc.). In order to manage skin wound, a variety of wound dressings have been developed, including gauze, films, foams, nanofibers, hydrocolloids, and hydrogels. Recently, hydrogels have received much attention because of their natural extracellular matrix (ECM)‐mimik structure, tunable mechanical properties, and facile bioactive substance delivery capability. They show great potential application in skin wound repair. This paper first introduces the anatomy and function of the skin, the process of wound healing and conventional wound dressings, and then introduces the composition and construction methods of hydrogels. Next, this paper introduces the necessary properties of hydrogels in skin wound repair and the latest research progress of hydrogel dressings for skin wound repair. Finally, the future development goals of hydrogel materials in the field of wound healing are proposed.

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Injectable and Degradable PEG Hydrogel with Antibacterial Performance for Promoting Wound Healing

Cited by 50 publications

References 48 publications

3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration

3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration

Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model

Progress in Hydrogels for Skin Wound Repair

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