Development of the Renal Arterioles

López, María Luisa S. Sequeira; Gómez, R. Ariel

doi:10.1681/asn.2011080818

Cited by 125 publications

(77 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, embryonic ablation of several RAS components in rodents results in renal developmental pathologies indicating the requirement of the RAS during renal development (23,55,66,71). Axitinib, a highly selective inhibitor of VEGF receptors 1-3, inhibits angiogenesis in both mammals (26) and zebrafish (8,81).…”

Section: Angiogenesis and Renin-expressing Cellsmentioning

confidence: 99%

Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium

Rider

Mullins

Verdon

et al. 2015

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

Rider SA, Mullins LJ, Verdon RF, MacRae CA, Mullins JJ. Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium. Am J Physiol Renal Physiol 309: F531-F539, 2015. First published July 22, 2015 doi:10.1152/ajprenal.00247.2015.-Although renin is a critical regulatory enzyme of the cardiovascular system, its roles in organogenesis and the establishment of cardiovascular homeostasis remain unclear. Mammalian renin-expressing cells are widespread in embryonic kidneys but are highly restricted, specialized endocrine cells in adults. With a functional pronephros, embryonic zebrafish are ideal for delineating the developmental functions of renin-expressing cells and the mechanisms governing renin transcription. Larval zebrafish renin expression originates in the mural cells of the juxtaglomerular anterior mesenteric artery and subsequently at extrarenal sites. The role of renin was determined by assessing responses to renin-angiotensin system blockade, salinity variation, and renal perfusion ablation. Renin expression did not respond to renal flow ablation but was modulated by inhibition of angiotensin-converting enzyme and altered salinity. Our data in larval fish are consistent with conservation of renin's physiological functions. Using transgenic renin reporter fish, with mindbomb and cloche mutants, we show that Notch signaling and the endothelium are essential for developmental renin expression. After inhibition of angiogenesis, renin-expressing cells precede angiogenic sprouts. Arising from separate lineages, but relying on mutual interplay with endothelial cells, renin-expressing cells are among the earliest mural cells observed in larval fish, performing both endocrine and paracrine functions. renin; zebrafish; notch; endothelium; angiogenesis RENIN is the rate-limiting enzyme of the renin-angiotensin system (RAS). Mammalian ANG II, the effector of the RAS, is principally involved in blood pressure homeostasis by regulation of vasomotor tone and Na ϩ retention. ANG II also regulates cell proliferation and angiogenesis (12,22). Pathological activation of the RAS is associated with cardiovascular diseases, including hypertension and heart failure, and is consequently a major target of therapeutic agents (11).Renin and its cognate cells are required for normal renal development (2), including angiogenesis of the renal vascular tree (59). In mice, ablation of the renin gene or renin-expressing cells leads to renal developmental abnormalities (55,71,79). The vasculature of mammalian embryonic kidneys have a transient but extensive coverage of mural renin-expressing cells (17,31,32,47,63); however, their function is unclear. Adult renin-expressing cells are restricted to the juxtaglomerular apparatus and play a vital role in ion homeostasis by secreting activated renin enzyme via cytoplasmic granules (17,31,36,63). Upon physiological challenge by RAS inhibition or low Na ϩ , prearteriolar vascular smooth muscle cells (VSMC) reestablish their embryonic re...

show abstract

Section: Angiogenesis and Renin-expressing Cellsmentioning

confidence: 99%

Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium

Rider

Mullins

Verdon

et al. 2015

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

show abstract

“…They derive from FoxD1-positive stromal cells. 66 They participate in kidney vasculature assembly and branching, and thereafter are normally distributed along large intrarenal arteries. Studies led by Gomez shows that CoRL can differentiate into smooth muscle cells, mesangial cells, and maybe pericytes too.…”

Section: Cells Of Renin Lineage As Adult Podocyte Progenitorsmentioning

confidence: 99%

Progenitor Cells and Podocyte Regeneration

Shankland¹,

Pippin²,

Duffield³

2014

Seminars in Nephrology

View full text Add to dashboard Cite

The very limited ability of adult podocytes to proliferate in vivo is clinically significant because: podocytes form a vascular barrier which is functionally critical to the nephron; podocyte hypoplasia is a characteristic of disease; and inadequate regeneration of podocytes is a major cause of persistent podocyte hypoplasia. Excessive podocyte loss or inadequate replacement leads to glomerulosclerosis in many progressive kidney diseases. Thus, restoration of podocyte cell density is almost certainly reliant on regeneration by podocyte progenitors. However such putative progenitors have remained elusive until recently. In this review we describe the developmental processes leading to podocyte and parietal epithelial cell (PEC) formation during glomerulogenesis. We compare evidence that in normal human kidneys PECs expressing ‘progenitor’ markers CD133 and CD24 can differentiate into podocytes in vitro and in vivo with evidence from animal models suggesting a more limited role of PEC-capacity to serve as podocyte progenitors in adults. We will highlight tantalizing new evidence that specialized vascular wall cells of afferent arterioles including those which produce renin in healthy kidney, provide a novel local progenitor source of new PECs and podocytes in response to podocyte hypoplasia in the adult, and draw comparisons with glomerulogenesis.

show abstract

“…The formation of the developing vasculature throughout organogenesis and as the kidney develops is the combination of two biological processes; the first being angiogenesis, which is defined by the outgrowth (sprouting) of vessels from an established central vessel [1–3]. In the renal vasculature there are two primary angiogenic sites: vessels that sprout off the renal artery and the formation of the vasa recta, which branches off the efferent arterioles.…”

Section: Introductionmentioning

confidence: 99%

Unwrapping the origins and roles of the renal endothelium

Stolz

Sims‐Lucas

2014

Pediatr Nephrol

View full text Add to dashboard Cite

The renal vasculature, like all vessels, is lined by simple squamous epithelium, called an endothelium. These endothelial-lined vessels can be subdivided into four major compartments: arteries, veins, capillaries and lymphatics. The renal vasculature is a highly integrated network that forms through the active processes of angiogenesis and vasculogenesis. The precise contribution of these two processes and the molecular signaling that governs the differentiation, specification and maturation of these critical cell populations is an actively evolving field. Though much of the focus has concentrated on the origin of the glomerular capillaries, this review extends the investigation to the origins of the endothelial cells throughout the entire kidney and the signaling events that cause their distinct functional and molecular profiles. A thorough understanding of endothelial cell biology may play a critical role in better understanding renal vascular diseases.

show abstract

Development of the Renal Arterioles

Cited by 125 publications

References 64 publications

Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium

Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium

Progenitor Cells and Podocyte Regeneration

Unwrapping the origins and roles of the renal endothelium

Contact Info

Product

Resources

About