Development of the Progestational Uterus: Metabolic Aspects

Yochim, JM

doi:10.1095/biolreprod12.1.106

Cited by 42 publications

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“…In the ovariectomized females in our study, the progestin, alone or in combina-tion with oestradiol, increased FDP hydrolysis by 35 %, whereas oestradiol alone raised it to 75 % over that present in control tissue extracts. These findings support the hypothesis of Yochim (1975) that progesterone generates a pattern of metabolism, whereas the effect of oestrogen is to increase the rate of metabolism in the pattern. Moulton (1974) observed a similar potentiating effect of oestrogen on progesterone-stimulated glucose-6-phosphate dehydrogenase activity in deciduomal tissue of the rat but this does not seem to occur with the endometrial esterases (Boshier & Katz, 1975).…”

Section: Discussionsupporting

confidence: 88%

“…Hormones were injected s.c. and the regimens were : Group 5, ovariectomized controls ; Group 6,0-2 ml arachis oil daily ; Group 7,0-1 pg oestradiol- Doyle & Margolis (1964). After the animals had resumed normal oestrous cycles, they were killed at pro-oestrus or metoestrus, periods of high and low uterine activity respectively (Boshier & Katz, 1975;Yochim, 1975).…”

Section: Methodsmentioning

confidence: 99%

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Fructose metabolism in the rat endometrium under normal and experimental conditions

Boshier¹,

Katz²

1976

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Summary. Fructose-1,6-diphosphate (FDP) hydrolysis, which was measured in tissue extracts from mature rat endometrium, was maximal during late dioestrus and early pro-oestrus and reflected the variations in the plasma levels of ovarian steroids. Treatment of ovariectomized animals with oestradiol or medroxyprogesterone acetate increased FDP hydrolysis when compared with control animals, although oestradiol was the more effective. FDP hydrolysis was greater in extracts of endometrial tissue from uterine horns containing a silk IUD or of deciduomal tissue from pseudopregnant rats, in which the peak was on Day 9, than in extracts of endometrium from the control contralateral horn. These findings are interpreted as linking glycogen metabolism in normal endometrium, IUD-containing horns, and decidual tissue to the role of FDP in gluconeogenesis and the promotion of glycogen storage.

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Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Fructose metabolism in the rat endometrium under normal and experimental conditions

Boshier¹,

Katz²

1976

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“…The decidua of the uterus at this stage of pregnancy is a metabolically active tissue in which macromolecular synthesis occurs for cellular multiplication (Yochim, 1975). Some labelled products of the degenerated embryos could be incorporated into these macromolecules or undergo catabolism, as glycolysis is markedly increased in the decidual tissue at the time of implantation (O'Grady & Bell, 1977).…”

Section: Discussionmentioning

confidence: 99%

Degradation of biochemical pools labelled with [14C]glucose during culture of 8-cell and morula--early blastocyst-stage mouse embryos in vitro and in vivo

Edirisinghe¹,

Wales²,

Pike³

1984

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When 8-cell mouse embryos were chase cultured for 24 h in vitro or in vivo (in uteri of pseudopregnant mice) there was no indication of utilization of the small amount of acid-soluble glycogen synthesized during the pulse. At the morula-early blastocyst stage of development almost 50% of the label incorporated during the pulse was found in the acid-soluble glycogen fraction. The biochemical pools at this stage were relatively stable in vitro and in vivo during a short (5 h) chase period. However, marked degradation of the acid-soluble glycogen pool occurred during long periods of exposure to the uterine environment and, over 48 h in utero, almost all of the label was lost from this pool. By contrast, embryos cultured in vitro for the same period retained greater than 60% of their acid-soluble glycogen. Utilization of glucose carbon in the acid-insoluble glycogen fraction occurred during in-vitro and in-vivo chase but there was a suggestion that the change in vivo was less than that in vitro. The non-glycogen macromolecular pool was relatively stable except during extended chase culture of morulae-early blastocysts when some utilization occurred. Under these conditions utilization was less in utero than in vitro. The experiments show that the uterine environment has a marked influence on the metabolism, particularly of glycogen, of the embryo and indicate that some factor in the uterus causes net degradation of acid-soluble glycogen by the embryo at the late preimplantation stage of development.

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“…The increased protein content in the lumen during pregnancy may be due, at least in part, to the secretion of uterine-specific proteins. Oestradiol is known to cause the synthesis of nonhistone chromosomal proteins in the uterus (Cohen & Hamilton, 1975) (Yochim, 1975).…”

Section: Discussionmentioning

confidence: 99%

Uterine luminal proteins at the time of implantation in rats

Surani¹

1976

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Development of the Progestational Uterus: Metabolic Aspects

Cited by 42 publications

References 0 publications

Fructose metabolism in the rat endometrium under normal and experimental conditions

Fructose metabolism in the rat endometrium under normal and experimental conditions

Degradation of biochemical pools labelled with [14C]glucose during culture of 8-cell and morula--early blastocyst-stage mouse embryos in vitro and in vivo

Uterine luminal proteins at the time of implantation in rats

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