Development of the mesencephalic and diencephalic catecholamine systems in human fetuses: uptake and release of catecholamines in vitro

Ugrumov, M. V.; Proshlyakova, E. V.; Sapronova, A. Ya.; Popov, A. P.

doi:10.1016/0304-3940(96)12764-6

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Comparing the developmental stages of the locus coeruleus and substantia nigra neurons in rats and humans, O'Rahilly and collaborators (1987) suggested that embryonic days 13-15 in the rat approximatively corresponded to Carnegie stages 15-18 (4.5 to 6 postovulatory weeks) in humans. Indeed, our results and those of other teams, show the presence of TH immunoreactive CA groups during the embryonic period in humans (Almqvist et al, 1996;Freeman et al, 1991;Puelles and Verney, 1998;Ugrumov et al, 1996;Verney et al, 1991;Zecevic and Verney, 1995).…”

Section: Development Of Catecholamine-containing Neurons In Human Embsupporting

confidence: 77%

Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses

Verney

1999

Microsc. Res. Tech.

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Section: Development Of Catecholamine-containing Neurons In Human Embsupporting

confidence: 77%

Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses

Verney

1999

Microsc. Res. Tech.

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“…However, by 12 weeks, reuptake per unit weight of nerve tissue decreased, because the weight of nerve tissue increased faster during this time than the surfaces of neurons able to take dopamine up. Unlike the situation with reuptake, dopamine secretion in response to potassium depolarization of membranes was not seen during the period from week 6 to week 12 [23]. This means that in humans, unlike rodents [9], there is a significant dissociation in time between the formation of reuptake mechanisms and stimulated dopamine release.…”

Section: Differentiation and Transplantation Of Dopaminergic Neurons contrasting

confidence: 59%

“…However, this parameter is not absolutely specific, because TH can be expressed transiently in embryogenesis [7] as well as in neurons lacking aromatic L-amino acid decarboxylase [5,12,14]. These studies were therefore supplemented by identification of the time at which specific reuptake and secretion of dopamine in response to membrane depolarization develop, using a biochemical isotope-based method [23]. Specific dopamine uptake was recorded in human embryos as early as week 6, demonstrating the presence of dopaminergic neurons and the expression of their synthesis of the dopamine transport protein.…”

Section: Differentiation and Transplantation Of Dopaminergic Neurons mentioning

confidence: 99%

The differentiation of dopaminergic neurons in situ, in vivo, and in transplants

Ugryumov

2000

Neurosci Behav Physiol

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This article summarizes results obtained from studies on the differentiation of dopaminergic neurons in animal hypothalamus and human substantia nigra in situ, in vitro, and in transplants, as well as the role of the microenvironment in regulating this process. Four stages were identified in the differentiation of dopaminergic neurons from rat hypothalamus: a) formation of neurons from neuroepithelial precursor cells, b) expression of specific synthetic products (enzymes and dopamine itself) and mechanisms for transmembrane dopamine transport (reuptake and secretion in response to membrane depolarization), c) formation of permanent and transient efferent connections, and d) formation of afferent innervation and synaptogenesis. Along with dopaminergic neurons, rat fetuses contained neurons expressing only one of the dopamine-synthesizing enzymes and probably taking part in in situ dopamine synthesis. Differentiation of dopaminergic neurons was sexually dimorphic in terms of the dynamics of neuron formation and expression of enzymes involved in dopamine synthesis. A neurotransplantation model showed that humoral factors of placental and maternal origin had no significant effect on the differentiation of the dopaminergic neurons of the hypothalamus. As regards the dopaminergic neurons of the substantia nigra, expression of their specific phenotype in human fetuses started with the synthesis of tyrosine hydroxylase and co-maturation of the specific dopamine reuptake mechanism during the sixth week of development. During the next four weeks, specific uptake increased, and this appears to be a measure of the number of neurons and the growth of their processes. These data provide the basis for regarding the period from week 6 to week 10 as optimal for transplantation of dopaminergic neurons into the striatum of patients with Parkinson's disease. Suspensions of fetal substantia nigra cells enriched with dopaminergic neurons were introduced stereotaxically into a patient's striatum through a cannula. Positron emission tomography studies showed that the transplanted neurons survived within the host brain, underwent differentiation, and started to synthesize dopamine. The results of clinical assessment performed in parallel with these studies suggested that the transplanted dopaminergic neurons were involved in regulating striatal target neurons.

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Prenatal Development of the Human Fetal Telencephalon

Judaš

2010

Medical Radiology

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Development of the mesencephalic and diencephalic catecholamine systems in human fetuses: uptake and release of catecholamines in vitro

Cited by 6 publications

References 22 publications

Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses

Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses

The differentiation of dopaminergic neurons in situ, in vivo, and in transplants

Prenatal Development of the Human Fetal Telencephalon

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