Development of the fluorometric ELISA method for determination of α 1 -microglobulinuria in a cadmium-polluted area in Japan

Cai, Yunqing; Teranishi, Hidetoyo; Aoshima, Keiko; Katoh, Takahiko; Arai, Yôko; Kasuya, Minoru

doi:10.1007/s004200100249

Cited by 8 publications

(6 citation statements)

References 13 publications

(15 reference statements)

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“…Zinc is an essential component of the oxidant defense system and functions at many levels (Sato and Bremner, 1993). One study has shown that Zn deficiency in the diet paves the way for cell damage in the rat testis (Cai et al, 2001). Furthermore, Zn deficiency increases lipid peroxidation in various rat tissues, whereas the Zn supplementation corrects the impairment (Ozdemir and Inanc, 2005;Ozturk et al, 2003;Shaheen and El-Fattah, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…A series of metabolic and autoimmune diseases are successfully being treated with camel's milk (Al-Hashem, 2009). In India, camel's milk is used therapeutically against dropsy, jaundice, problems of the spleen, tuberculosis, asthma, anemia, piles and diabetes (Cai et al, 2001). Beneficial role of raw camel's milk in chronic pulmonary tuberculosis patients has been observed (Mal et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

Afifi¹

2010

American Journal of Biochemistry and Biotechnology

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Problem statement: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Camel's milk has good nutritive value, antigenotoxic and anticytotoxic effects. The aim of the present study was to assess the protective effect of camel's milk against Cisplatin-induced renal oxidative stress in mice. Approach: Forty mal Swiss albino mice were randomly divided into four groups (n = 10). Group I, control group. Group II was received cisplatin (12 mg kg −1) for 5 alternate days. Group III was received camel's milk (33 mL kg −1) for consecutive 30 days. Group IV was received camel's milk (33 mL kg −1) for consecutive 30 days before administration of Cisplatin. Results: Cisplatin-induced oxidative stress was indicated by increased level of tissue Malondialdehyde (MDA), serum creatinine and urea, decreased the concentration of reduced Glutathione (GSH), Vitamin C (Vit. C) and Vitamin E (Vit. E) and decreased both activities and gene expression of Superoxid Dismutase (SOD), Catalase (CAT), Glutathione Raductase (GR) and Glutathione Peroxidase (GPx). Camel's milk reduced these biochemical changes and counteracted the deleterious effects of cisplatin Conclusion: The present study demonstrated the renoprotective potential of camel's milk against cisplatin-induced oxidative stress and renal dysfunction in mice. Hence, camel's milk has a potential to be used as therapeutic adjuvant in cisplatin nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

Afifi¹

2010

American Journal of Biochemistry and Biotechnology

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“…Zinc is an essential component of the oxidant defense system and functions at many levels [74] . One study has shown that a diet deficient in Zn paves the way for cell damage in the rat testis [75] . Furthermore, Zn deficiency increases lipid peroxidation in various rat tissues, whereas the Zn supplementation corrects this increase [72,73,76] .…”

Section: Discussionmentioning

confidence: 99%

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Al‐Hashem¹

2009

American Journal of Biochemistry and Biotechnology

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Problem statement: Aluminum chloride (AlCl 3 ) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel's milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: a control group treated with normal saline, the AlCl 3 -treated group and the camel's milk-AlCl 3 -treated group. The AlCl 3 treated group received 0.5 mg kg −1 of AlCl 3 orally. The camel's milk-AlCl 3 -treated group was fed 1 mL of fresh camel's milk 10 minutes prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Liver and kidney biochemical serum parameters were analyzed. Lipid peroxidation, as determined by the tissue concentrations of thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP), and the oxidative stress status, as measured by glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) activity, were evaluated in the kidney and liver of treated rats. Results: Data showed that the oral administration of AlCl 3 resulted in statistically significant increases in the serum levels of urea, creatinine, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol and triglycerides; the total amount of protein and albumin were also significantly decreased. However, these parameters were within normal levels in the rats given camel's milk prior to AlCl 3 . Additionally, oral administration of AlCl 3 induced lipid peroxidation in the liver and kidney, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the activities of GSH, SOD and CAT. In all rats treated with camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were within normal levels. Conclusion: Treatment with camel's milk prior to AlCl 3 exposure alleviates AlCl 3 -associated hazards and protects the kidney and liver from AlCl 3 toxicity.

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“…One study has shown that Zn deficiency in the diet paves the way for cell damage in the rat's testis [66] . Furthermore, Zn deficiency increases lipid peroxidation in various rat tissues and Zn supplementation corrects this impairment [66][67][68][69] . Interestingly, Zn has been reported to protect against cadmium-induced cellular toxicity in vitro [70] .…”

Section: Discussionmentioning

confidence: 99%

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

Al‐Hashem¹

2009

American J. of Applied Sciences

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Problem statement: The present study was carried out to examine the effectiveness of Camel's milk in alleviating aluminum chloride (AlCl 3 )-induced oxidative stress and lipid peroxidation in rat testes. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: A control group, treated with normal saline and two experimental groups, the AlCl 3 treated group and the Camel's milk-AlCl 3 treated group. The first experimental group, the AlCl 3 treated group, received 0.5 mg kg −1 of AlCl 3 orally. The second experimental group was fed 1 mL of fresh Camel's milk 10 min prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Lipid peroxidation, as determined by testicular concentration of Thiobarbituric Acid Reactive Substances (TBARS) and Hydroperoxide (HP) levels and the oxidative stress status, as measured by glutathione (GSH) levels, Superoxide Dismutase (SOD) and Catalase (CAT) activity, were evaluated in the rat testes. Results: Oral administration of AlCl 3 induced lipid peroxidation and oxidative stress in rat testes, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the GSH content and SOD and CAT activities. When rats received Camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were restored to normal levels. In the testes from rats fed Camel's milk TBARS and HP levels were significantly reduced and, conversely, GSH content, SOD and CAT activities were significantly increased compared to rats that received only AlCl 3 . Conclusion: Treatment with Camel's milk prior to AlCl 3 alleviates AlCl 3 -associated hazards and protects testicular tissue from AlCl 3 toxicity.

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Development of the fluorometric ELISA method for determination of α 1 -microglobulinuria in a cadmium-polluted area in Japan

Abstract: These results suggest that this fluorometric ELISA is a useful tool to determine urinary alpha1-m in the epidemiological survey of renal tubular dysfunction, especially in the cadmium-polluted area of Japan.

Cited by 8 publications

References 13 publications

Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

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Development of the fluorometric ELISA method for determination of α 1 -microglobulinuria in a cadmium-polluted area in Japan

Abstract: These results suggest that this fluorometric ELISA is a useful tool to determine urinary alpha1-m in the epidemiological survey of renal tubular dysfunction, especially in the cadmium-polluted area of Japan.

Cited by 8 publications

References 13 publications

Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

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Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice

Effect of Camelâs Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice